geldanamycin-5588 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the geldanamycin-5588 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADCY7 adenylate cyclase 7
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
ALS2CL ALS2 C-terminal like
AMT aminomethyltransferase
ARID4B AT rich interactive domain 4B (RBP1-like)
ATAT1 alpha tubulin acetyltransferase 1
ATF6B activating transcription factor 6 beta
BIN1 bridging integrator 1
BMP4 bone morphogenetic protein 4
BST2 bone marrow stromal cell antigen 2
BTN3A1 butyrophilin, subfamily 3, member A1
CCNG2 cyclin G2
CD209 CD209 molecule
CDC42 cell division cycle 42
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CRY2 cryptochrome circadian clock 2
CSRP2 cysteine and glycine-rich protein 2
CTIF CBP80/20-dependent translation initiation factor
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DDIT4 DNA-damage-inducible transcript 4
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB5 DnaJ (Hsp40) homolog, subfamily B, member 5
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
FAM46C family with sequence similarity 46, member C
FKBP14 FK506 binding protein 14, 22 kDa
FNDC3B fibronectin type III domain containing 3B
FSTL1 follistatin-like 1
GHRHR growth hormone releasing hormone receptor
GLRX glutaredoxin (thioltransferase)
GYPB glycophorin B (MNS blood group)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
ICA1 islet cell autoantigen 1, 69kDa
IL6R interleukin 6 receptor
ING4 inhibitor of growth family, member 4
INSIG1 insulin induced gene 1
KRT16 keratin 16, type I
KRT19P2 keratin 19 pseudogene 2
MANF mesencephalic astrocyte-derived neurotrophic factor
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MFAP3 microfibrillar-associated protein 3
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NAP1L2 nucleosome assembly protein 1-like 2
NBL1 neuroblastoma 1, DAN family BMP antagonist
OSGIN1 oxidative stress induced growth inhibitor 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PCDHB11 protocadherin beta 11
PDIA4 protein disulfide isomerase family A, member 4
PGF placental growth factor
POPDC3 popeye domain containing 3
PPID peptidylprolyl isomerase D
PRSS16 protease, serine, 16 (thymus)
PSAT1 phosphoserine aminotransferase 1
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAB6A RAB6A, member RAS oncogene family
RAB6B RAB6B, member RAS oncogene family
RAI2 retinoic acid induced 2
RFPL2 ret finger protein-like 2
RGS2 regulator of G-protein signaling 2
RNASE4 ribonuclease, RNase A family, 4
RRN3P1 RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 1
SCN11A sodium channel, voltage gated, type XI alpha subunit
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BGR SH3 domain binding glutamate-rich protein
SH3GL3 SH3-domain GRB2-like 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNX1 sorting nexin 1
SOX9 SRY (sex determining region Y)-box 9
STYK1 serine/threonine/tyrosine kinase 1
SYNDIG1 synapse differentiation inducing 1
TES testin LIM domain protein
TMED7 transmembrane emp24 protein transport domain containing 7
TMEM50B transmembrane protein 50B
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TRIM2 tripartite motif containing 2
TTLL7 tubulin tyrosine ligase-like family member 7
ULBP2 UL16 binding protein 2
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF10 zinc finger protein 10
ZNF165 zinc finger protein 165
ZNF227 zinc finger protein 227
ZNF235 zinc finger protein 235
ZNF236 zinc finger protein 236
ZNF329 zinc finger protein 329

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
ADGRA3 adhesion G protein-coupled receptor A3
ANKRD36B ankyrin repeat domain 36B
ASTE1 asteroid homolog 1 (Drosophila)
BAHCC1 BAH domain and coiled-coil containing 1
BCAS1 breast carcinoma amplified sequence 1
C11ORF80 chromosome 11 open reading frame 80
C1ORF56 chromosome 1 open reading frame 56
C5AR2 complement component 5a receptor 2
C7ORF43 chromosome 7 open reading frame 43
CA11 carbonic anhydrase XI
CALHM2 calcium homeostasis modulator 2
CCDC88C coiled-coil domain containing 88C
CD3EAP CD3e molecule, epsilon associated protein
CD82 CD82 molecule
CFAP44 cilia and flagella associated protein 44
CFD complement factor D (adipsin)
CLMN calmin (calponin-like, transmembrane)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DUSP2 dual specificity phosphatase 2
EFNA3 ephrin-A3
EGR3 early growth response 3
ERCC4 excision repair cross-complementation group 4
EXD3 exonuclease 3'-5' domain containing 3
FAM120C family with sequence similarity 120C
FAM184A family with sequence similarity 184, member A
FKBP5 FK506 binding protein 5
FLCN folliculin
FRMD1 FERM domain containing 1
FZD4 frizzled class receptor 4
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GPR19 G protein-coupled receptor 19
HDAC11 histone deacetylase 11
HECA headcase homolog (Drosophila)
HIST1H3B histone cluster 1, H3b
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IDI2-AS1 IDI2 antisense RNA 1
IER2 immediate early response 2
IFT54 intraflagellar transport 54
IRF9 interferon regulatory factor 9
IRX5 iroquois homeobox 5
JUNB jun B proto-oncogene
KIAA0319L KIAA0319-like
KLF10 Kruppel-like factor 10
KLF11 Kruppel-like factor 11
LIN7A lin-7 homolog A (C. elegans)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LRFN4 leucine rich repeat and fibronectin type III domain containing 4
LZTR1 leucine-zipper-like transcription regulator 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP6D1 MAP6 domain containing 1
MMP15 matrix metallopeptidase 15 (membrane-inserted)
MNT MAX network transcriptional repressor
MOCS3 molybdenum cofactor synthesis 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
PARD6A par-6 family cell polarity regulator alpha
PCF11 PCF11 cleavage and polyadenylation factor subunit
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
PRKCD protein kinase C, delta
PRR14L proline rich 14-like
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RBM14 RNA binding motif protein 14
RCAN3 RCAN family member 3
RGS16 regulator of G-protein signaling 16
RHBDF2 rhomboid 5 homolog 2 (Drosophila)
RIBC2 RIB43A domain with coiled-coils 2
RNF126P1 ring finger protein 126 pseudogene 1
SDC3 syndecan 3
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMAD7 SMAD family member 7
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SPINK4 serine peptidase inhibitor, Kazal type 4
SYTL2 synaptotagmin-like 2
TEAD3 TEA domain family member 3
THEM6 thioesterase superfamily member 6
TMEM62 transmembrane protein 62
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV6 transient receptor potential cation channel, subfamily V, member 6
TTC13 tetratricopeptide repeat domain 13
ULK1 unc-51 like autophagy activating kinase 1
VGF VGF nerve growth factor inducible
VWA1 von Willebrand factor A domain containing 1
WDR25 WD repeat domain 25
XYLT2 xylosyltransferase II
ZBED1 zinc finger, BED-type containing 1
ZNF205 zinc finger protein 205
ZNF282 zinc finger protein 282
ZNF580 zinc finger protein 580
ZXDC ZXD family zinc finger C