geldanamycin-611 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the geldanamycin-611 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGR2 anterior gradient 2
AIM1L absent in melanoma 1-like
APOOL apolipoprotein O-like
ARHGAP5 Rho GTPase activating protein 5
ARMCX3 armadillo repeat containing, X-linked 3
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATF2 activating transcription factor 2
C6ORF47 chromosome 6 open reading frame 47
CADM3 cell adhesion molecule 3
CASP9 caspase 9, apoptosis-related cysteine peptidase
CDKN2A cyclin-dependent kinase inhibitor 2A
CHN1 chimerin 1
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CREBZF CREB/ATF bZIP transcription factor
CRMP1 collapsin response mediator protein 1
CSRP2 cysteine and glycine-rich protein 2
DDIT4 DNA-damage-inducible transcript 4
DIO2 deiodinase, iodothyronine, type II
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EDEM2 ER degradation enhancer, mannosidase alpha-like 2
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7
EPS8L1 EPS8-like 1
FGFR2 fibroblast growth factor receptor 2
FNDC3B fibronectin type III domain containing 3B
FXR2 fragile X mental retardation, autosomal homolog 2
GLRX glutaredoxin (thioltransferase)
GLTSCR1 glioma tumor suppressor candidate region gene 1
GPATCH1 G patch domain containing 1
GRIP2 glutamate receptor interacting protein 2
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HLA-G major histocompatibility complex, class I, G
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
HYOU1 hypoxia up-regulated 1
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma
IDUA iduronidase, alpha-L-
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
KIF18A kinesin family member 18A
LRIF1 ligand dependent nuclear receptor interacting factor 1
LRRC61 leucine rich repeat containing 61
MAP4 microtubule-associated protein 4
MBNL2 muscleblind-like splicing regulator 2
MBOAT7 membrane bound O-acyltransferase domain containing 7
MIR22HG MIR22 host gene
MVK mevalonate kinase
NCR2 natural cytotoxicity triggering receptor 2
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NUCB2 nucleobindin 2
OBSL1 obscurin-like 1
OVGP1 oviductal glycoprotein 1, 120kDa
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PADI1 peptidyl arginine deiminase, type I
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDIA4 protein disulfide isomerase family A, member 4
PDK3 pyruvate dehydrogenase kinase, isozyme 3
PHKG1 phosphorylase kinase, gamma 1 (muscle)
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PPARD peroxisome proliferator-activated receptor delta
PPM1B protein phosphatase, Mg2+/Mn2+ dependent, 1B
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic)
RABGGTB Rab geranylgeranyltransferase, beta subunit
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RCAN1 regulator of calcineurin 1
RGS2 regulator of G-protein signaling 2
RPS2 ribosomal protein S2
SDF2L1 stromal cell-derived factor 2-like 1
SEC24A SEC24 family member A
SEC24D SEC24 family member D
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SH3BGR SH3 domain binding glutamate-rich protein
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIL1 SIL1 nucleotide exchange factor
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
STK19 serine/threonine kinase 19
TES testin LIM domain protein
TFAP4 transcription factor AP-4 (activating enhancer binding protein 4)
TH tyrosine hydroxylase
TMED5 transmembrane emp24 protein transport domain containing 5
TMED7 transmembrane emp24 protein transport domain containing 7
TSPYL2 TSPY-like 2
TULP3 tubby like protein 3
WDR18 WD repeat domain 18
WIPI1 WD repeat domain, phosphoinositide interacting 1
ZNF165 zinc finger protein 165
ZNHIT2 zinc finger, HIT-type containing 2

decreased expression

Symbol Name
ACKR3 atypical chemokine receptor 3
AEN apoptosis enhancing nuclease
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
APEX2 APEX nuclease (apurinic/apyrimidinic endonuclease) 2
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARMC7 armadillo repeat containing 7
BYSL bystin-like
C2CD5 C2 calcium-dependent domain containing 5
C9ORF3 chromosome 9 open reading frame 3
CA11 carbonic anhydrase XI
CALHM2 calcium homeostasis modulator 2
CAMKV CaM kinase-like vesicle-associated
CFAP74 cilia and flagella associated protein 74
CIC capicua transcriptional repressor
CLSTN2 calsyntenin 2
COBL cordon-bleu WH2 repeat protein
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa
CTNNBIP1 catenin, beta interacting protein 1
CTPS1 CTP synthase 1
DUSP22 dual specificity phosphatase 22
ELP3 elongator acetyltransferase complex subunit 3
EPB41L5 erythrocyte membrane protein band 4.1 like 5
EPN3 epsin 3
ESRP2 epithelial splicing regulatory protein 2
EXOC3 exocyst complex component 3
FAM63A family with sequence similarity 63, member A
FHOD1 formin homology 2 domain containing 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
FUZ fuzzy planar cell polarity protein
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C
GMIP GEM interacting protein
HELLS helicase, lymphoid-specific
HIST1H4J histone cluster 1, H4j
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER2 immediate early response 2
ILK integrin-linked kinase
ITPKB inositol-trisphosphate 3-kinase B
KLF10 Kruppel-like factor 10
KLF15 Kruppel-like factor 15
KLF7 Kruppel-like factor 7 (ubiquitous)
KLHL3 kelch-like family member 3
KLK8 kallikrein-related peptidase 8
LENEP lens epithelial protein
LHX6 LIM homeobox 6
LMO3 LIM domain only 3 (rhombotin-like 2)
MLYCD malonyl-CoA decarboxylase
MNX1 motor neuron and pancreas homeobox 1
MST1R macrophage stimulating 1 receptor
MTERF3 mitochondrial transcription termination factor 3
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAT6 N-acetyltransferase 6 (GCN5-related)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NIPAL2 NIPA-like domain containing 2
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PDZD7 PDZ domain containing 7
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PMEPA1 prostate transmembrane protein, androgen induced 1
POMT1 protein-O-mannosyltransferase 1
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PRKCD protein kinase C, delta
PWP2 PWP2 periodic tryptophan protein homolog (yeast)
RAD54L RAD54-like (S. cerevisiae)
RAP1GAP2 RAP1 GTPase activating protein 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RBM14 RNA binding motif protein 14
RGS19 regulator of G-protein signaling 19
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCO2 SCO2 cytochrome c oxidase assembly protein
SCUBE2 signal peptide, CUB domain, EGF-like 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SYTL2 synaptotagmin-like 2
TAOK1 TAO kinase 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TGM3 transglutaminase 3
THBS4 thrombospondin 4
TLN2 talin 2
TRAPPC12 trafficking protein particle complex 12
TRIM21 tripartite motif containing 21
TSNAXIP1 translin-associated factor X interacting protein 1
UBE2G2 ubiquitin-conjugating enzyme E2G 2
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
VIM vimentin
VWA1 von Willebrand factor A domain containing 1
WDR13 WD repeat domain 13
ZCCHC6 zinc finger, CCHC domain containing 6
ZFP36 ZFP36 ring finger protein
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF394 zinc finger protein 394