gelsemine-4177 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the gelsemine-4177 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACPP acid phosphatase, prostate
ADAM12 ADAM metallopeptidase domain 12
AFF1 AF4/FMR2 family, member 1
APAF1 apoptotic peptidase activating factor 1
APOBEC1 apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
AQP6 aquaporin 6, kidney specific
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BMP10 bone morphogenetic protein 10
CARTPT CART prepropeptide
CD101 CD101 molecule
CD6 CD6 molecule
CDC14B cell division cycle 14B
CDKN2A cyclin-dependent kinase inhibitor 2A
CDON cell adhesion associated, oncogene regulated
CEP41 centrosomal protein 41kDa
COL7A1 collagen, type VII, alpha 1
CRHR2 corticotropin releasing hormone receptor 2
CST2 cystatin SA
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
ELOVL2 ELOVL fatty acid elongase 2
F5 coagulation factor V (proaccelerin, labile factor)
FBXO40 F-box protein 40
FGA fibrinogen alpha chain
FSHB follicle stimulating hormone, beta polypeptide
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GAS7 growth arrest-specific 7
GBP1 guanylate binding protein 1, interferon-inducible
GLS glutaminase
GPR3 G protein-coupled receptor 3
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A
GRK5 G protein-coupled receptor kinase 5
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HNF4A hepatocyte nuclear factor 4, alpha
HOXA6 homeobox A6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGL immunoglobulin lambda locus
IL1RN interleukin 1 receptor antagonist
KANK1 KN motif and ankyrin repeat domains 1
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIR2DL1 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
KRT17 keratin 17, type I
KRT38 keratin 38, type I
LBP lipopolysaccharide binding protein
LOXL2 lysyl oxidase-like 2
LRMP lymphoid-restricted membrane protein
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
LRRN2 leucine rich repeat neuronal 2
MBD2 methyl-CpG binding domain protein 2
MCAM melanoma cell adhesion molecule
MEG3 maternally expressed 3 (non-protein coding)
MID1 midline 1
MTMR3 myotubularin related protein 3
NOS2 nitric oxide synthase 2, inducible
NPTX2 neuronal pentraxin II
NTNG1 netrin G1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
OR2H2 olfactory receptor, family 2, subfamily H, member 2
OR7A17 olfactory receptor, family 7, subfamily A, member 17
PCNXL2 pecanex-like 2 (Drosophila)
PKNOX2 PBX/knotted 1 homeobox 2
PLEKHG3 pleckstrin homology domain containing, family G (with RhoGef domain) member 3
POU5F1B POU class 5 homeobox 1B
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRODH2 proline dehydrogenase (oxidase) 2
PRPH2 peripherin 2 (retinal degeneration, slow)
PRSS12 protease, serine, 12 (neurotrypsin, motopsin)
PTGDS prostaglandin D2 synthase 21kDa (brain)
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated)
RBMS3 RNA binding motif, single stranded interacting protein 3
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
S100A8 S100 calcium binding protein A8
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SERHL2 serine hydrolase-like 2
SIGLEC7 sialic acid binding Ig-like lectin 7
SIX3 SIX homeobox 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC35G2 solute carrier family 35, member G2
SLCO4C1 solute carrier organic anion transporter family, member 4C1
SOGA1 suppressor of glucose, autophagy associated 1
SPON1 spondin 1, extracellular matrix protein
SSX3 synovial sarcoma, X breakpoint 3
TBCD tubulin folding cofactor D
THY1 Thy-1 cell surface antigen
TMPRSS11D transmembrane protease, serine 11D
TSC22D3 TSC22 domain family, member 3
USF2 upstream transcription factor 2, c-fos interacting
ZNF518A zinc finger protein 518A
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ADGRE1 adhesion G protein-coupled receptor E1
ADGRG2 adhesion G protein-coupled receptor G2
ADORA3 adenosine A3 receptor
AMPD1 adenosine monophosphate deaminase 1
ARC activity-regulated cytoskeleton-associated protein
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
BMP4 bone morphogenetic protein 4
C14ORF79 chromosome 14 open reading frame 79
C3AR1 complement component 3a receptor 1
CD8A CD8a molecule
CDH18 cadherin 18, type 2
CDK3 cyclin-dependent kinase 3
CDK6 cyclin-dependent kinase 6
CEL carboxyl ester lipase
CFHR4 complement factor H-related 4
CHKB choline kinase beta
CHML choroideremia-like (Rab escort protein 2)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COPZ2 coatomer protein complex, subunit zeta 2
CRYGC crystallin, gamma C
CTSO cathepsin O
CUL9 cullin 9
CUZD1 CUB and zona pellucida-like domains 1
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DEAF1 DEAF1 transcription factor
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
FAM131A family with sequence similarity 131, member A
FAM212B family with sequence similarity 212, member B
FLJ11710 uncharacterized protein FLJ11710
GADD45G growth arrest and DNA-damage-inducible, gamma
GAMT guanidinoacetate N-methyltransferase
GFI1 growth factor independent 1 transcription repressor
GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPR157 G protein-coupled receptor 157
GPR182 G protein-coupled receptor 182
GSTP1 glutathione S-transferase pi 1
GSTTP1 glutathione S-transferase theta pseudogene 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HOXC8 homeobox C8
IGSF6 immunoglobulin superfamily, member 6
IPPK inositol 1,3,4,5,6-pentakisphosphate 2-kinase
IQSEC2 IQ motif and Sec7 domain 2
IVL involucrin
KIAA0319L KIAA0319-like
LHX3 LIM homeobox 3
LHX6 LIM homeobox 6
LOC100287590 uncharacterized LOC100287590
LOXL3 lysyl oxidase-like 3
LY6G6C lymphocyte antigen 6 complex, locus G6C
LY86 lymphocyte antigen 86
MADCAM1 mucosal vascular addressin cell adhesion molecule 1
MAP6D1 MAP6 domain containing 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MFGE8 milk fat globule-EGF factor 8 protein
MFSD11 major facilitator superfamily domain containing 11
MOB3B MOB kinase activator 3B
N4BP2L2-IT2 N4BPL2 intronic transcript 2
NAT6 N-acetyltransferase 6 (GCN5-related)
NPR3 natriuretic peptide receptor 3
PCDHA9 protocadherin alpha 9
PENK proenkephalin
PEX26 peroxisomal biogenesis factor 26
PLA2G1B phospholipase A2, group IB (pancreas)
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PQLC2 PQ loop repeat containing 2
PSG4 pregnancy specific beta-1-glycoprotein 4
PTPRM protein tyrosine phosphatase, receptor type, M
REM1 RAS (RAD and GEM)-like GTP-binding 1
RHBG Rh family, B glycoprotein (gene/pseudogene)
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF32 ring finger protein 32
RPA4 replication protein A4, 30kDa
SCN1B sodium channel, voltage gated, type I beta subunit
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SKI SKI proto-oncogene
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SNCAIP synuclein, alpha interacting protein
SPINK5 serine peptidase inhibitor, Kazal type 5
STIM1 stromal interaction molecule 1
SYNC syncoilin, intermediate filament protein
TAS2R4 taste receptor, type 2, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TEX14 testis expressed 14
TMCC2 transmembrane and coiled-coil domain family 2
TPSG1 tryptase gamma 1
USB1 U6 snRNA biogenesis 1
VIPR1 vasoactive intestinal peptide receptor 1
WDR62 WD repeat domain 62
WNT10B wingless-type MMTV integration site family, member 10B
WNT16 wingless-type MMTV integration site family, member 16
ZIM2 zinc finger, imprinted 2
ZNF230 zinc finger protein 230
ZNF428 zinc finger protein 428
ZNF76 zinc finger protein 76
ZNF862 zinc finger protein 862
ZSWIM1 zinc finger, SWIM-type containing 1