gemcitabine Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A 2'-deoxycytidine having geminal fluoro substituents in the 2'-position. An inhibitor of ribonucleotide reductase, gemcitabine is used in the treatment of various carcinomas, particularly non-small cell lung cancer, pancreatic cancer, bladder cancer and breast cancer. (Chemical Entities of Biological Interest Ontology, CHEBI_175901)
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Genes

90 genes co-occuring with the biological term gemcitabine in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANXA2 annexin A2
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
AQP3 aquaporin 3 (Gill blood group)
BCL2A1 BCL2-related protein A1
BCL2L2 BCL2-like 2
BHLHE40 basic helix-loop-helix family, member e40
BIRC5 baculoviral IAP repeat containing 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BRS3 bombesin-like receptor 3
CAPG capping protein (actin filament), gelsolin-like
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD44 CD44 molecule (Indian blood group)
CDA cytidine deaminase
CHFR checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
CSF3R colony stimulating factor 3 receptor (granulocyte)
CSNK2A1 casein kinase 2, alpha 1 polypeptide
CYCS cytochrome c, somatic
DCK deoxycytidine kinase
DIABLO diablo, IAP-binding mitochondrial protein
EGFR epidermal growth factor receptor
EIF5A eukaryotic translation initiation factor 5A
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FKBP5 FK506 binding protein 5
HMGA1 high mobility group AT-hook 1
HSPB1 heat shock 27kDa protein 1
ISG15 ISG15 ubiquitin-like modifier
KAT7 K(lysine) acetyltransferase 7
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MCL1 myeloid cell leukemia 1
MIR133B microRNA 133b
MIR142 microRNA 142
MIR181B1 microRNA 181b-1
MIR205 microRNA 205
MIR21 microRNA 21
MIR221 microRNA 221
MIR29B1 microRNA 29b-1
MIR320C1 microRNA 320c-1
MIR497 microRNA 497
MST1R macrophage stimulating 1 receptor
MUC4 mucin 4, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
NFE2L2 nuclear factor, erythroid 2-like 2
NOTCH1 notch 1
NOTCH2 notch 2
NOTCH3 notch 3
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
ORC2 origin recognition complex, subunit 2
PARK7 parkinson protein 7
PDGFD platelet derived growth factor D
PGK1 phosphoglycerate kinase 1
PIM3 Pim-3 proto-oncogene, serine/threonine kinase
PLK1 polo-like kinase 1
PRDX2 peroxiredoxin 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PVT1 Pvt1 oncogene (non-protein coding)
PYCARD PYD and CARD domain containing
RAD17 RAD17 homolog (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
RUNX3 runt-related transcription factor 3
SBF1 SET binding factor 1
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRI sorcin
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TERF2 telomeric repeat binding factor 2
TERT telomerase reverse transcriptase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TP63 tumor protein p63
UBE2M ubiquitin-conjugating enzyme E2M
VEGFA vascular endothelial growth factor A
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZNF195 zinc finger protein 195