gemfibrozil-1430 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the gemfibrozil-1430 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
AAK1 AP2 associated kinase 1
APOBR apolipoprotein B receptor
ARMC7 armadillo repeat containing 7
BMP15 bone morphogenetic protein 15
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
C5ORF45 chromosome 5 open reading frame 45
C7ORF26 chromosome 7 open reading frame 26
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCNF cyclin F
CCNG2 cyclin G2
CD84 CD84 molecule
CDC42SE1 CDC42 small effector 1
CKB creatine kinase, brain
CLCN3 chloride channel, voltage-sensitive 3
CSN2 casein beta
CYB561 cytochrome b561
DCAF15 DDB1 and CUL4 associated factor 15
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DUS2 dihydrouridine synthase 2
DUSP1 dual specificity phosphatase 1
DXO decapping exoribonuclease
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
E2F4 E2F transcription factor 4, p107/p130-binding
EHD1 EH-domain containing 1
ELMO2 engulfment and cell motility 2
ERCC4 excision repair cross-complementation group 4
FAM107A family with sequence similarity 107, member A
FAM86B1 family with sequence similarity 86, member B1
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GLRX3 glutaredoxin 3
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial
GPSM3 G-protein signaling modulator 3
GSK3A glycogen synthase kinase 3 alpha
GSTM4 glutathione S-transferase mu 4
HIST1H4C histone cluster 1, H4c
HIST1H4J histone cluster 1, H4j
HNRNPL heterogeneous nuclear ribonucleoprotein L
IGF1R insulin-like growth factor 1 receptor
KDM2A lysine (K)-specific demethylase 2A
KIAA1109 KIAA1109
LIG3 ligase III, DNA, ATP-dependent
LMTK1 lemur tail kinase 1
LRRN2 leucine rich repeat neuronal 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MBIP MAP3K12 binding inhibitory protein 1
MED12 mediator complex subunit 12
MED6 mediator complex subunit 6
METTL13 methyltransferase like 13
MID2 midline 2
MSRB2 methionine sulfoxide reductase B2
MST1 macrophage stimulating 1
MVK mevalonate kinase
N4BP1 NEDD4 binding protein 1
NGLY1 N-glycanase 1
NHEJ1 nonhomologous end-joining factor 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
OCRL oculocerebrorenal syndrome of Lowe
PADI1 peptidyl arginine deiminase, type I
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PKNOX2 PBX/knotted 1 homeobox 2
PLCD1 phospholipase C, delta 1
PSG3 pregnancy specific beta-1-glycoprotein 3
QTRT1 queuine tRNA-ribosyltransferase 1
RAP2C RAP2C, member of RAS oncogene family
RBM25 RNA binding motif protein 25
RBM4B RNA binding motif protein 4B
RPP25 ribonuclease P/MRP 25kDa subunit
RPS11 ribosomal protein S11
SBNO1 strawberry notch homolog 1 (Drosophila)
SDC2 syndecan 2
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin
SIGLEC15 sialic acid binding Ig-like lectin 15
SIRT3 sirtuin 3
SLN sarcolipin
SPIDR scaffolding protein involved in DNA repair
SPN sialophorin
STAB2 stabilin 2
TEX40 testis expressed 40
TFE3 transcription factor binding to IGHM enhancer 3
THBS3 thrombospondin 3
THRA thyroid hormone receptor, alpha
TMEM260 transmembrane protein 260
TMPRSS11D transmembrane protease, serine 11D
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNIK TRAF2 and NCK interacting kinase
TNS1 tensin 1
TREX1 three prime repair exonuclease 1
TRIM9 tripartite motif containing 9
TTLL4 tubulin tyrosine ligase-like family member 4
URI1 URI1, prefoldin-like chaperone
WSB1 WD repeat and SOCS box containing 1
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZKSCAN4 zinc finger with KRAB and SCAN domains 4

decreased expression

Symbol Name
ABHD3 abhydrolase domain containing 3
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
C19ORF40 chromosome 19 open reading frame 40
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase
CD151 CD151 molecule (Raph blood group)
CDC37L1 cell division cycle 37-like 1
CFAP74 cilia and flagella associated protein 74
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CISD1 CDGSH iron sulfur domain 1
CLDND1 claudin domain containing 1
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides
DENND4A DENN/MADD domain containing 4A
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DMTF1 cyclin D binding myb-like transcription factor 1
DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
ERF Ets2 repressor factor
FADS2 fatty acid desaturase 2
GBP2 guanylate binding protein 2, interferon-inducible
GDI1 GDP dissociation inhibitor 1
GMEB1 glucocorticoid modulatory element binding protein 1
GMPPA GDP-mannose pyrophosphorylase A
GSR glutathione reductase
GTF2F2 general transcription factor IIF, polypeptide 2, 30kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HAGH hydroxyacylglutathione hydrolase
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFNA17 interferon, alpha 17
INO80D INO80 complex subunit D
KCTD3 potassium channel tetramerization domain containing 3
KIF23 kinesin family member 23
KIFAP3 kinesin-associated protein 3
KIFC1 kinesin family member C1
KLF2 Kruppel-like factor 2
LOC642236 FSHD region gene 1 pseudogene
LRP5L low density lipoprotein receptor-related protein 5-like
LYZ lysozyme
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGOHB mago-nashi homolog B (Drosophila)
MAGT1 magnesium transporter 1
MCM9 minichromosome maintenance complex component 9
MED4 mediator complex subunit 4
MED9 mediator complex subunit 9
METRN meteorin, glial cell differentiation regulator
MEX3C mex-3 RNA binding family member C
MGAM maltase-glucoamylase
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MPC1 mitochondrial pyruvate carrier 1
MXRA8 matrix-remodelling associated 8
NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit
NHLRC2 NHL repeat containing 2
NPDC1 neural proliferation, differentiation and control, 1
NRBP1 nuclear receptor binding protein 1
NXPH3 neurexophilin 3
PAK1IP1 PAK1 interacting protein 1
PAQR3 progestin and adipoQ receptor family member III
PCDHGB5 protocadherin gamma subfamily B, 5
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PNRC1 proline-rich nuclear receptor coactivator 1
POLI polymerase (DNA directed) iota
POTEKP POTE ankyrin domain family, member K, pseudogene
PTER phosphotriesterase related
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RBL1 retinoblastoma-like 1
RNASE6 ribonuclease, RNase A family, k6
RNASEL ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
RNF144A ring finger protein 144A
RP2 retinitis pigmentosa 2 (X-linked recessive)
RRP1 ribosomal RNA processing 1
RWDD3 RWD domain containing 3
SDHAF3 succinate dehydrogenase complex assembly factor 3
SEC61B Sec61 beta subunit
SFMBT1 Scm-like with four mbt domains 1
SNX15 sorting nexin 15
STXBP3 syntaxin binding protein 3
SUCO SUN domain containing ossification factor
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TMA7 translation machinery associated 7 homolog (S. cerevisiae)
TOB1 transducer of ERBB2, 1
TPRA1 transmembrane protein, adipocyte asscociated 1
TRAPPC11 trafficking protein particle complex 11
TRPM2 transient receptor potential cation channel, subfamily M, member 2
TTF2 transcription termination factor, RNA polymerase II
TUBA3C tubulin, alpha 3c
UBE2NL ubiquitin-conjugating enzyme E2N-like (gene/pseudogene)
UCKL1 uridine-cytidine kinase 1-like 1
VILL villin-like
WWP2 WW domain containing E3 ubiquitin protein ligase 2
XKR8 XK, Kell blood group complex subunit-related family, member 8
ZCCHC10 zinc finger, CCHC domain containing 10
ZEB2 zinc finger E-box binding homeobox 2
ZNF107 zinc finger protein 107