gemfibrozil-2277 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the gemfibrozil-2277 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8
ACAP1 ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
ACTL8 actin-like 8
ADGRL3 adhesion G protein-coupled receptor L3
AKR1D1 aldo-keto reductase family 1, member D1
AKT2 v-akt murine thymoma viral oncogene homolog 2
ANKLE2 ankyrin repeat and LEM domain containing 2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BLNK B-cell linker
BMP10 bone morphogenetic protein 10
BST2 bone marrow stromal cell antigen 2
C1QL1 complement component 1, q subcomponent-like 1
CD3D CD3d molecule, delta (CD3-TCR complex)
CD4 CD4 molecule
CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1
CFHR4 complement factor H-related 4
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CNTN5 contactin 5
CRYGD crystallin, gamma D
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTIF CBP80/20-dependent translation initiation factor
DCTN2 dynactin 2 (p50)
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DOPEY2 dopey family member 2
DRP2 dystrophin related protein 2
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2
FBLN1 fibulin 1
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GPATCH4 G patch domain containing 4
GPER1 G protein-coupled estrogen receptor 1
GPR137 G protein-coupled receptor 137
GPR157 G protein-coupled receptor 157
GPR182 G protein-coupled receptor 182
GPR37L1 G protein-coupled receptor 37 like 1
GREB1L growth regulation by estrogen in breast cancer-like
GSTP1 glutathione S-transferase pi 1
HAAO 3-hydroxyanthranilate 3,4-dioxygenase
HDAC7 histone deacetylase 7
HMGN5 high mobility group nucleosome binding domain 5
IL11 interleukin 11
KCNJ4 potassium channel, inwardly rectifying subfamily J, member 4
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIF25 kinesin family member 25
KIF25-AS1 KIF25 antisense RNA 1
KIFC3 kinesin family member C3
LOX lysyl oxidase
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MMP13 matrix metallopeptidase 13
MNMIP1 manchette microtubule inner protein 1
MRC2 mannose receptor, C type 2
MSR1 macrophage scavenger receptor 1
MUC8 mucin 8
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NGF nerve growth factor (beta polypeptide)
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
OAZ3 ornithine decarboxylase antizyme 3
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1
PARD6B par-6 family cell polarity regulator beta
PARVB parvin, beta
PDC phosducin
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
PHLPP2 PH domain and leucine rich repeat protein phosphatase 2
PICALM phosphatidylinositol binding clathrin assembly protein
PLD1 phospholipase D1, phosphatidylcholine-specific
POFUT1 protein O-fucosyltransferase 1
PON1 paraoxonase 1
PRSS3 protease, serine, 3
PSD3 pleckstrin and Sec7 domain containing 3
PTRF polymerase I and transcript release factor
RABGAP1 RAB GTPase activating protein 1
RUNX1 runt-related transcription factor 1
SARDH sarcosine dehydrogenase
SCNN1B sodium channel, non voltage gated 1 beta subunit
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC39A9 solute carrier family 39, member 9
SOX10 SRY (sex determining region Y)-box 10
SPTBN1 spectrin, beta, non-erythrocytic 1
SRGN serglycin
SSX3 synovial sarcoma, X breakpoint 3
STMN2 stathmin 2
SZT2 seizure threshold 2 homolog (mouse)
TAOK2 TAO kinase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM63A transmembrane protein 63A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UPK3B uroplakin 3B
USB1 U6 snRNA biogenesis 1
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
ZBED4 zinc finger, BED-type containing 4
ZFAND5 zinc finger, AN1-type domain 5
ZNF419 zinc finger protein 419
ZNF721 zinc finger protein 721
ZSWIM1 zinc finger, SWIM-type containing 1

decreased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain
ACTG2 actin, gamma 2, smooth muscle, enteric
ADTRP androgen-dependent TFPI-regulating protein
ALS2CL ALS2 C-terminal like
ARMC4 armadillo repeat containing 4
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BEGAIN brain-enriched guanylate kinase-associated
BFSP1 beaded filament structural protein 1, filensin
BMP4 bone morphogenetic protein 4
BTF3P12 basic transcription factor 3 pseudogene 12
C22ORF46 chromosome 22 open reading frame 46
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAMTA2 calmodulin binding transcription activator 2
CD3EAP CD3e molecule, epsilon associated protein
CDK18 cyclin-dependent kinase 18
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLCF1 cardiotrophin-like cytokine factor 1
CUZD1 CUB and zona pellucida-like domains 1
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DGAT1 diacylglycerol O-acyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DUSP2 dual specificity phosphatase 2
EXOC6B exocyst complex component 6B
FAM184A family with sequence similarity 184, member A
FAM198B family with sequence similarity 198, member B
FAM76A family with sequence similarity 76, member A
FBXW4P1 F-box and WD repeat domain containing 4 pseudogene 1
FLCN folliculin
FLJ11710 uncharacterized protein FLJ11710
GABRR2 gamma-aminobutyric acid (GABA) A receptor, rho 2
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GATA4 GATA binding protein 4
GFI1 growth factor independent 1 transcription repressor
GLS2 glutaminase 2 (liver, mitochondrial)
GRB7 growth factor receptor-bound protein 7
GRPR gastrin-releasing peptide receptor
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2AJ histone cluster 1, H2aj
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
IPO8 importin 8
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITPKC inositol-trisphosphate 3-kinase C
JPH3 junctophilin 3
KLHL28 kelch-like family member 28
KREMEN2 kringle containing transmembrane protein 2
LIF leukemia inhibitory factor
LTC4S leukotriene C4 synthase
LY6G6C lymphocyte antigen 6 complex, locus G6C
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MALL mal, T-cell differentiation protein-like
MRPL41 mitochondrial ribosomal protein L41
MTA2 metastasis associated 1 family, member 2
N4BP3 NEDD4 binding protein 3
NDE1 nudE neurodevelopment protein 1
NRGN neurogranin (protein kinase C substrate, RC3)
OSMR oncostatin M receptor
PAIP2B poly(A) binding protein interacting protein 2B
PARP16 poly (ADP-ribose) polymerase family, member 16
PLEKHA6 pleckstrin homology domain containing, family A member 6
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLH polymerase (DNA directed), eta
POMT2 protein-O-mannosyltransferase 2
PTPRS protein tyrosine phosphatase, receptor type, S
RAB36 RAB36, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RNF208 ring finger protein 208
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SCRN3 secernin 3
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SLC17A2 solute carrier family 17, member 2
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SPTBN2 spectrin, beta, non-erythrocytic 2
STMN3 stathmin-like 3
TCP10 t-complex 10
TFF2 trefoil factor 2
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TOM1 target of myb1 (chicken)
TOPORS topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TSC22D4 TSC22 domain family, member 4
VAX2 ventral anterior homeobox 2
WLS wntless Wnt ligand secretion mediator
YY2 YY2 transcription factor
ZFHX3 zinc finger homeobox 3
ZFP37 ZFP37 zinc finger protein
ZKSCAN3 zinc finger with KRAB and SCAN domains 3
ZNF136 zinc finger protein 136
ZNF197 zinc finger protein 197
ZNF204P zinc finger protein 204, pseudogene
ZNF254 zinc finger protein 254
ZNF574 zinc finger protein 574
ZNF747 zinc finger protein 747
ZNF76 zinc finger protein 76