gemfibrozil-5488 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the gemfibrozil-5488 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AFF1 AF4/FMR2 family, member 1
AGMAT agmatine ureohydrolase (agmatinase)
ARHGDIG Rho GDP dissociation inhibitor (GDI) gamma
C5AR1 complement component 5a receptor 1
CALD1 caldesmon 1
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASD1 CAS1 domain containing 1
CCDC93 coiled-coil domain containing 93
CCL21 chemokine (C-C motif) ligand 21
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8
CNTN1 contactin 1
CREBZF CREB/ATF bZIP transcription factor
CRIP1 cysteine-rich protein 1 (intestinal)
CTBP2 C-terminal binding protein 2
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CUL9 cullin 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4F12 cytochrome P450, family 4, subfamily F, polypeptide 12
DICER1 dicer 1, ribonuclease type III
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
EDRF1 erythroid differentiation regulatory factor 1
EGR1 early growth response 1
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa
ELN elastin
FAM120C family with sequence similarity 120C
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
GIMAP5 GTPase, IMAP family member 5
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNS glucosamine (N-acetyl)-6-sulfatase
GPA33 glycoprotein A33 (transmembrane)
GPM6B glycoprotein M6B
GPR21 G protein-coupled receptor 21
GSPT1 G1 to S phase transition 1
GTF2A1 general transcription factor IIA, 1, 19/37kDa
HMGN5 high mobility group nucleosome binding domain 5
IFNA17 interferon, alpha 17
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IL1B interleukin 1, beta
ITGA8 integrin, alpha 8
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
KCNK10 potassium channel, two pore domain subfamily K, member 10
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KIAA0125 KIAA0125
KLHL25 kelch-like family member 25
LENEP lens epithelial protein
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LMF1 lipase maturation factor 1
LOC257152 uncharacterized LOC257152
MAPK11 mitogen-activated protein kinase 11
MARK4 MAP/microtubule affinity-regulating kinase 4
MFAP5 microfibrillar associated protein 5
MIA2 melanoma inhibitory activity 2
MTMR2 myotubularin related protein 2
MYB v-myb avian myeloblastosis viral oncogene homolog
MYL10 myosin, light chain 10, regulatory
MZF1 myeloid zinc finger 1
N4BP1 NEDD4 binding protein 1
N4BP3 NEDD4 binding protein 3
NF1 neurofibromin 1
NF2 neurofibromin 2 (merlin)
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRG1 neuregulin 1
NSUN6 NOP2/Sun domain family, member 6
OR3A3 olfactory receptor, family 3, subfamily A, member 3
OSGIN1 oxidative stress induced growth inhibitor 1
OSMR oncostatin M receptor
PCDHGB5 protocadherin gamma subfamily B, 5
PCSK6 proprotein convertase subtilisin/kexin type 6
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PI4K2A phosphatidylinositol 4-kinase type 2 alpha
POU5F1B POU class 5 homeobox 1B
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
PTCRA pre T-cell antigen receptor alpha
PTPN2 protein tyrosine phosphatase, non-receptor type 2
RAD51B RAD51 paralog B
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RUFY3 RUN and FYVE domain containing 3
SAG S-antigen; retina and pineal gland (arrestin)
SAMD4A sterile alpha motif domain containing 4A
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SH3BP2 SH3-domain binding protein 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SLN sarcolipin
SREBF2 sterol regulatory element binding transcription factor 2
STON1 stonin 1
SZT2 seizure threshold 2 homolog (mouse)
TADA2A transcriptional adaptor 2A
TGFBR3 transforming growth factor, beta receptor III
TMEM209 transmembrane protein 209
TMPRSS3 transmembrane protease, serine 3
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZMYND8 zinc finger, MYND-type containing 8
ZNF318 zinc finger protein 318
ZNF821 zinc finger protein 821

decreased expression

Symbol Name
AP4M1 adaptor-related protein complex 4, mu 1 subunit
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
BAHD1 bromo adjacent homology domain containing 1
C1ORF35 chromosome 1 open reading frame 35
C5ORF45 chromosome 5 open reading frame 45
CDK5RAP2 CDK5 regulatory subunit associated protein 2
CENPO centromere protein O
CHML choroideremia-like (Rab escort protein 2)
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLEC4E C-type lectin domain family 4, member E
CRELD1 cysteine-rich with EGF-like domains 1
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DNAH17 dynein, axonemal, heavy chain 17
DOCK1 dedicator of cytokinesis 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EHD3 EH-domain containing 3
ERN2 endoplasmic reticulum to nucleus signaling 2
FAM53B family with sequence similarity 53, member B
FBRS fibrosin
FBXO31 F-box protein 31
FGGY FGGY carbohydrate kinase domain containing
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2
FOSL1 FOS-like antigen 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GOLGA8B golgin A8 family, member B
GRINA glutamate receptor, ionotropic, N-methyl D-aspartate-associated protein 1 (glutamate binding)
HIST1H1D histone cluster 1, H1d
HOXC10 homeobox C10
IL17RB interleukin 17 receptor B
IL2 interleukin 2
IMPDH1 IMP (inosine 5'-monophosphate) dehydrogenase 1
IRF1 interferon regulatory factor 1
KLF2 Kruppel-like factor 2
KLHL26 kelch-like family member 26
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LZTS3 leucine zipper, putative tumor suppressor family member 3
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MBOAT2 membrane bound O-acyltransferase domain containing 2
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MFSD11 major facilitator superfamily domain containing 11
MICALL2 MICAL-like 2
MITF microphthalmia-associated transcription factor
MMP9 matrix metallopeptidase 9
MOSPD3 motile sperm domain containing 3
MTMR11 myotubularin related protein 11
MYO1D myosin ID
NHEJ1 nonhomologous end-joining factor 1
NOL12 nucleolar protein 12
NPFFR1 neuropeptide FF receptor 1
OGFRL1 opioid growth factor receptor-like 1
ONECUT2 one cut homeobox 2
PC pyruvate carboxylase
PDK2 pyruvate dehydrogenase kinase, isozyme 2
PDLIM2 PDZ and LIM domain 2 (mystique)
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLEKHA6 pleckstrin homology domain containing, family A member 6
PODXL2 podocalyxin-like 2
POLL polymerase (DNA directed), lambda
POLR3D polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
PROCR protein C receptor, endothelial
PSKH1 protein serine kinase H1
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RBM38 RNA binding motif protein 38
REM1 RAS (RAD and GEM)-like GTP-binding 1
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF122 ring finger protein 122
RNF25 ring finger protein 25
RNF43 ring finger protein 43
RPL23AP32 ribosomal protein L23a pseudogene 32
SAMHD1 SAM domain and HD domain 1
SETD8 SET domain containing (lysine methyltransferase) 8
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SLC12A9 solute carrier family 12, member 9
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SMA4 glucuronidase, beta pseudogene
SMG9 SMG9 nonsense mediated mRNA decay factor
SP140L SP140 nuclear body protein-like
STX1A syntaxin 1A (brain)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TIGD6 tigger transposable element derived 6
TMC7 transmembrane channel-like 7
TMEM134 transmembrane protein 134
TMEM57 transmembrane protein 57
TRABD TraB domain containing
TUBA3D tubulin, alpha 3d
USB1 U6 snRNA biogenesis 1
WDR47 WD repeat domain 47
XYLT2 xylosyltransferase II
ZKSCAN4 zinc finger with KRAB and SCAN domains 4
ZNF276 zinc finger protein 276
ZNF571 zinc finger protein 571
ZSCAN16 zinc finger and SCAN domain containing 16
ZSCAN26 zinc finger and SCAN domain containing 26