genotoxic Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
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Genes

178 genes co-occuring with the biological term genotoxic in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACHE acetylcholinesterase (Yt blood group)
AICDA activation-induced cytidine deaminase
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANXA2 annexin A2
APAF1 apoptotic peptidase activating factor 1
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1
APP amyloid beta (A4) precursor protein
APTX aprataxin
AS3MT arsenite methyltransferase
ATF2 activating transcription factor 2
ATM ATM serine/threonine kinase
ATR ATR serine/threonine kinase
AXIN1 axin 1
BAG3 BCL2-associated athanogene 3
BAG6 BCL2-associated athanogene 6
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BARD1 BRCA1 associated RING domain 1
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BRCA1 breast cancer 1, early onset
BRINP1 bone morphogenetic protein/retinoic acid inducible neural-specific 1
C10ORF2 chromosome 10 open reading frame 2
CABIN1 calcineurin binding protein 1
CAPNS1 calpain, small subunit 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCAR2 cell cycle and apoptosis regulator 2
CCDC6 coiled-coil domain containing 6
CCNB1 cyclin B1
CCNE1 cyclin E1
CDC14B cell division cycle 14B
CDC25A cell division cycle 25A
CDC5L cell division cycle 5-like
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDIP1 cell death-inducing p53 target 1
CDK1 cyclin-dependent kinase 1
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CELF2 CUGBP, Elav-like family member 2
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CLSPN claspin
CREB1 cAMP responsive element binding protein 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DCLRE1A DNA cross-link repair 1A
DDB2 damage-specific DNA binding protein 2, 48kDa
DEK DEK proto-oncogene
DFNA5 deafness, autosomal dominant 5
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DUSP4 dual specificity phosphatase 4
E2F1 E2F transcription factor 1
E2F4 E2F transcription factor 4, p107/p130-binding
ECT2 epithelial cell transforming 2
EGR1 early growth response 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1
ERC1 ELKS/RAB6-interacting/CAST family member 1
ERCC3 excision repair cross-complementation group 3
ERCC5 excision repair cross-complementation group 5
ERCC6 excision repair cross-complementation group 6
EWSR1 EWS RNA-binding protein 1
FANCM Fanconi anemia, complementation group M
FAS Fas cell surface death receptor
FOXM1 forkhead box M1
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GDE1 glycerophosphodiester phosphodiesterase 1
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GPX1 glutathione peroxidase 1
GSTM1 glutathione S-transferase mu 1
GSTT1 glutathione S-transferase theta 1
GUCY2C guanylate cyclase 2C
H2AFX H2A histone family, member X
HDAC2 histone deacetylase 2
HDAC5 histone deacetylase 5
HIC1 hypermethylated in cancer 1
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HIPK2 homeodomain interacting protein kinase 2
HMGA2 high mobility group AT-hook 2
HRAS Harvey rat sarcoma viral oncogene homolog
HSPA1A heat shock 70kDa protein 1A
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL6 interleukin 6
ING1 inhibitor of growth family, member 1
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JUN jun proto-oncogene
KAT5 K(lysine) acetyltransferase 5
KMT2A lysine (K)-specific methyltransferase 2A
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAP3K8 mitogen-activated protein kinase kinase kinase 8
MAPK8 mitogen-activated protein kinase 8
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MDM4 MDM4, p53 regulator
MECOM MDS1 and EVI1 complex locus
MIR205 microRNA 205
MIR21 microRNA 21
MLH1 mutL homolog 1
MUC1 mucin 1, cell surface associated
NBN nibrin
NEK1 NIMA-related kinase 1
NET1 neuroepithelial cell transforming 1
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NOS2 nitric oxide synthase 2, inducible
NOTCH1 notch 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NRG1 neuregulin 1
NUCLEOLIN nucleolin multifunctional protein
OAZ1 ornithine decarboxylase antizyme 1
OGG1 8-oxoguanine DNA glycosylase
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP1 poly (ADP-ribose) polymerase 1
PDZD2 PDZ domain containing 2
PIDD1 p53-induced death domain protein 1
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLK1 polo-like kinase 1
PML promyelocytic leukemia
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
PON1 paraoxonase 1
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PRKCD protein kinase C, delta
PRKCE protein kinase C, epsilon
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RAD17 RAD17 homolog (S. pombe)
RAD23A RAD23 homolog A (S. cerevisiae)
RAD51 RAD51 recombinase
RAD9A RAD9 homolog A (S. pombe)
RB1 retinoblastoma 1
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RHOB ras homolog family member B
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1
RNF4 ring finger protein 4
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPS3 ribosomal protein S3
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRM2B ribonucleotide reductase M2 B (TP53 inducible)
SHPRH SNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligase
SIRT1 sirtuin 1
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SNAI1 snail family zinc finger 1
SPHK1 sphingosine kinase 1
SRSF6 serine/arginine-rich splicing factor 6
STK39 serine threonine kinase 39
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
THRAP3 thyroid hormone receptor associated protein 3
TIMELESS timeless circadian clock
TIPIN TIMELESS interacting protein
TK1 thymidine kinase 1, soluble
TNF tumor necrosis factor
TOP2A topoisomerase (DNA) II alpha 170kDa
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
TP63 tumor protein p63
TP73 tumor protein p73
TWIST1 twist family bHLH transcription factor 1
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7
USP10 ubiquitin specific peptidase 10
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UTRN utrophin
WEE1 WEE1 G2 checkpoint kinase
WSB1 WD repeat and SOCS box containing 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPC xeroderma pigmentosum, complementation group C
XPO1 exportin 1
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3