gentamicin-2245 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the gentamicin-2245 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD17B abhydrolase domain containing 17B
ACRV1 acrosomal vesicle protein 1
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARTN artemin
ATF7IP activating transcription factor 7 interacting protein
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C19ORF66 chromosome 19 open reading frame 66
C3 complement component 3
C3AR1 complement component 3a receptor 1
CASP2 caspase 2, apoptosis-related cysteine peptidase
CEACAM4 carcinoembryonic antigen-related cell adhesion molecule 4
CFAP69 cilia and flagella associated protein 69
CFDP1 craniofacial development protein 1
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCN7 chloride channel, voltage-sensitive 7
CLSTN3 calsyntenin 3
COL6A1 collagen, type VI, alpha 1
CTBS chitobiase, di-N-acetyl-
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DBF4B DBF4 zinc finger B
DGCR8 DGCR8 microprocessor complex subunit
DOCK10 dedicator of cytokinesis 10
DOK4 docking protein 4
DPF3 D4, zinc and double PHD fingers, family 3
ERCC4 excision repair cross-complementation group 4
ETV6 ets variant 6
GPATCH4 G patch domain containing 4
GRK5 G protein-coupled receptor kinase 5
GRM1 glutamate receptor, metabotropic 1
GTPBP1 GTP binding protein 1
HBEGF heparin-binding EGF-like growth factor
HFE hemochromatosis
ICAM1 intercellular adhesion molecule 1
IL17RC interleukin 17 receptor C
IPW imprinted in Prader-Willi syndrome (non-protein coding)
ITM2C integral membrane protein 2C
KLHL29 kelch-like family member 29
LRP4 low density lipoprotein receptor-related protein 4
LRRC8B leucine rich repeat containing 8 family, member B
MAGEA5 melanoma antigen family A5
MAN1A2 mannosidase, alpha, class 1A, member 2
MAPK7 mitogen-activated protein kinase 7
MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3
MED18 mediator complex subunit 18
MEF2C myocyte enhancer factor 2C
METTL7A methyltransferase like 7A
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MKL1 megakaryoblastic leukemia (translocation) 1
MSL3 male-specific lethal 3 homolog (Drosophila)
MTCP1 mature T-cell proliferation 1
MYF5 myogenic factor 5
MYL10 myosin, light chain 10, regulatory
NEB nebulin
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PARD6B par-6 family cell polarity regulator beta
PDCD6 programmed cell death 6
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PSMB2 proteasome (prosome, macropain) subunit, beta type, 2
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTK2B protein tyrosine kinase 2 beta
RABGAP1 RAB GTPase activating protein 1
RABGAP1L RAB GTPase activating protein 1-like
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RND1 Rho family GTPase 1
RNGTT RNA guanylyltransferase and 5'-phosphatase
RPL35A ribosomal protein L35a
RREB1 ras responsive element binding protein 1
RSG1 REM2 and RAB-like small GTPase 1
S100A8 S100 calcium binding protein A8
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SCUBE3 signal peptide, CUB domain, EGF-like 3
SIGLEC6 sialic acid binding Ig-like lectin 6
SIM2 single-minded family bHLH transcription factor 2
SKIL SKI-like proto-oncogene
SLC24A1 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SORT1 sortilin 1
SUGP1 SURP and G patch domain containing 1
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYNJ2 synaptojanin 2
TGM2 transglutaminase 2
THRB thyroid hormone receptor, beta
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM209 transmembrane protein 209
TRAPPC9 trafficking protein particle complex 9
TWF1 twinfilin actin binding protein 1
USP34 ubiquitin specific peptidase 34
VEZT vezatin, adherens junctions transmembrane protein
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721

decreased expression

Symbol Name
A4GALT alpha 1,4-galactosyltransferase
AKR1C2 aldo-keto reductase family 1, member C2
ALOX15 arachidonate 15-lipoxygenase
AMPD1 adenosine monophosphate deaminase 1
AMPD3 adenosine monophosphate deaminase 3
ANKRD7 ankyrin repeat domain 7
AP1S1 adaptor-related protein complex 1, sigma 1 subunit
ARID4A AT rich interactive domain 4A (RBP1-like)
BCL9 B-cell CLL/lymphoma 9
C2ORF54 chromosome 2 open reading frame 54
CA5BP1 carbonic anhydrase VB pseudogene 1
CCDC88C coiled-coil domain containing 88C
CCP110 centriolar coiled coil protein 110kDa
CDADC1 cytidine and dCMP deaminase domain containing 1
CDH10 cadherin 10, type 2 (T2-cadherin)
CDON cell adhesion associated, oncogene regulated
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHST10 carbohydrate sulfotransferase 10
CIDEB cell death-inducing DFFA-like effector b
CLDN1 claudin 1
CNKSR2 connector enhancer of kinase suppressor of Ras 2
COL9A2 collagen, type IX, alpha 2
CRYBB2P1 crystallin, beta B2 pseudogene 1
CSF1R colony stimulating factor 1 receptor
CUL9 cullin 9
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DIXDC1 DIX domain containing 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPY19L1P1 DPY19L1 pseudogene 1
EFNA3 ephrin-A3
ERMAP erythroblast membrane-associated protein (Scianna blood group)
FAM46C family with sequence similarity 46, member C
FGL1 fibrinogen-like 1
FKBP5 FK506 binding protein 5
FOXRED2 FAD-dependent oxidoreductase domain containing 2
FRS2 fibroblast growth factor receptor substrate 2
GAMT guanidinoacetate N-methyltransferase
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GPRC5D G protein-coupled receptor, class C, group 5, member D
HDAC5 histone deacetylase 5
HIST1H2BJ histone cluster 1, H2bj
HPX hemopexin
IL12RB1 interleukin 12 receptor, beta 1
IPO8 importin 8
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM8 lysine (K)-specific demethylase 8
KRT15 keratin 15, type I
KRT24 keratin 24, type I
LARP6 La ribonucleoprotein domain family, member 6
LINC01587 long intergenic non-protein coding RNA 1587
LOC729164 hCG1732469
LRRC8E leucine rich repeat containing 8 family, member E
MSI1 musashi RNA-binding protein 1
MVP major vault protein
MYL5 myosin, light chain 5, regulatory
MYOZ1 myozenin 1
NOL12 nucleolar protein 12
NPFFR1 neuropeptide FF receptor 1
NPM3 nucleophosmin/nucleoplasmin 3
NPR3 natriuretic peptide receptor 3
OLFML2A olfactomedin-like 2A
OTUD3 OTU deubiquitinase 3
OVOL1 ovo-like zinc finger 1
PARG poly (ADP-ribose) glycohydrolase
PILRB paired immunoglobin-like type 2 receptor beta
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PODNL1 podocan-like 1
POLL polymerase (DNA directed), lambda
POM121 POM121 transmembrane nucleoporin
POM121L2 POM121 transmembrane nucleoporin-like 2
PRODH proline dehydrogenase (oxidase) 1
RAB3A RAB3A, member RAS oncogene family
RFPL1S RFPL1 antisense RNA 1
RFPL3 ret finger protein-like 3
RGS20 regulator of G-protein signaling 20
RNPEPL1 arginyl aminopeptidase (aminopeptidase B)-like 1
SAYSD1 SAYSVFN motif domain containing 1
SCN1B sodium channel, voltage gated, type I beta subunit
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SIPA1 signal-induced proliferation-associated 1
SLC12A8 solute carrier family 12, member 8
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8
SLC44A1 solute carrier family 44 (choline transporter), member 1
SPON2 spondin 2, extracellular matrix protein
STMN3 stathmin-like 3
TRIM68 tripartite motif containing 68
TRPC5 transient receptor potential cation channel, subfamily C, member 5
UPP1 uridine phosphorylase 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VEGFB vascular endothelial growth factor B
VPS11 vacuolar protein sorting 11 homolog (S. cerevisiae)
ZBTB33 zinc finger and BTB domain containing 33
ZCWPW1 zinc finger, CW type with PWWP domain 1
ZNF37BP zinc finger protein 37B, pseudogene
ZNF532 zinc finger protein 532