gli1 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description GLI family zinc finger 1|This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] (NCBI Entrez Gene Database, 2735)
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Genes

81 genes co-occuring with the biological term gli1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AR androgen receptor
BCL2 B-cell CLL/lymphoma 2
BHLHE41 basic helix-loop-helix family, member e41
BID BH3 interacting domain death agonist
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DCAF7 DDB1 and CUL4 associated factor 7
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
ERCC1 excision repair cross-complementation group 1
ERCC2 excision repair cross-complementation group 2
ESR1 estrogen receptor 1
EWSR1 EWS RNA-binding protein 1
FEM1B fem-1 homolog b (C. elegans)
FERMT2 fermitin family member 2
FLI1 Fli-1 proto-oncogene, ETS transcription factor
FLT4 fms-related tyrosine kinase 4
FOXC2 forkhead box C2
GLI1 GLI family zinc finger 1
GLI2 GLI family zinc finger 2
GLI3 GLI family zinc finger 3
HES1 hes family bHLH transcription factor 1
HHIP hedgehog interacting protein
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1
IGFBP6 insulin-like growth factor binding protein 6
ITCH itchy E3 ubiquitin protein ligase
ITGA6 integrin, alpha 6
ITGAV integrin, alpha V
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB6 integrin, beta 6
JUN jun proto-oncogene
KPNB1 karyopherin (importin) beta 1
KRAS Kirsten rat sarcoma viral oncogene homolog
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MIR133B microRNA 133b
MIR202 microRNA 202
MIR218-1 microRNA 218-1
MLH1 mutL homolog 1
MMP11 matrix metallopeptidase 11
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NANOG Nanog homeobox
NOTCH1 notch 1
NRP2 neuropilin 2
NUMB numb homolog (Drosophila)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit
PRKCA protein kinase C, alpha
PTCH1 patched 1
RAB23 RAB23, member RAS oncogene family
REG4 regenerating islet-derived family, member 4
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
SHH sonic hedgehog
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMO smoothened, frizzled class receptor
SNAI1 snail family zinc finger 1
SOCS1 suppressor of cytokine signaling 1
SOX9 SRY (sex determining region Y)-box 9
STIL SCL/TAL1 interrupting locus
SUFU suppressor of fused homolog (Drosophila)
TGFB1 transforming growth factor, beta 1
TP53 tumor protein p53
TWIST1 twist family bHLH transcription factor 1
USF1 upstream transcription factor 1
USF2 upstream transcription factor 2, c-fos interacting
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
WWOX WW domain containing oxidoreductase
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZIC2 Zic family member 2