glibenclamide-1546 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the glibenclamide-1546 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACSBG2 acyl-CoA synthetase bubblegum family member 2
ALDH3B1 aldehyde dehydrogenase 3 family, member B1
AQP7 aquaporin 7
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAZ1B bromodomain adjacent to zinc finger domain, 1B
BCAN brevican
BIRC7 baculoviral IAP repeat containing 7
BMP2K BMP2 inducible kinase
C1ORF61 chromosome 1 open reading frame 61
C7ORF43 chromosome 7 open reading frame 43
CA12 carbonic anhydrase XII
CACFD1 calcium channel flower domain containing 1
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CALB2 calbindin 2
CAMKV CaM kinase-like vesicle-associated
CD2BP2 CD2 (cytoplasmic tail) binding protein 2
CDK10 cyclin-dependent kinase 10
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)
CLTA clathrin, light chain A
CNTFR ciliary neurotrophic factor receptor
COL18A1 collagen, type XVIII, alpha 1
CORT cortistatin
CPM carboxypeptidase M
DGCR11 DiGeorge syndrome critical region gene 11 (non-protein coding)
DGCR8 DGCR8 microprocessor complex subunit
DNAH7 dynein, axonemal, heavy chain 7
DSPP dentin sialophosphoprotein
DUSP26 dual specificity phosphatase 26 (putative)
EFR3B EFR3 homolog B (S. cerevisiae)
FSCN1 fascin actin-bundling protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
GAL galanin/GMAP prepropeptide
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNAO1 guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
GNL1 guanine nucleotide binding protein-like 1
GPX3 glutathione peroxidase 3
H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
IGHA1 immunoglobulin heavy constant alpha 1
IHH indian hedgehog
INSR insulin receptor
IQCC IQ motif containing C
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KIF25 kinesin family member 25
KIF3C kinesin family member 3C
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
LIMS2 LIM and senescent cell antigen-like domains 2
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LPPR3 lipid phosphate phosphatase-related protein type 3
MBP myelin basic protein
MISP mitotic spindle positioning
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MOB3B MOB kinase activator 3B
MRC2 mannose receptor, C type 2
MT3 metallothionein 3
MUC5AC mucin 5AC, oligomeric mucus/gel-forming
NCR2 natural cytotoxicity triggering receptor 2
NDRG2 NDRG family member 2
NPEPL1 aminopeptidase-like 1
NPIPB15 nuclear pore complex interacting protein family, member B15
OMG oligodendrocyte myelin glycoprotein
OR10H1 olfactory receptor, family 10, subfamily H, member 1
PADI1 peptidyl arginine deiminase, type I
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLCG1 phospholipase C, gamma 1
PLD2 phospholipase D2
PRB1 proline-rich protein BstNI subfamily 1
PRB3 proline-rich protein BstNI subfamily 3
PRDM14 PR domain containing 14
PSG4 pregnancy specific beta-1-glycoprotein 4
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTN pleiotrophin
RAB2A RAB2A, member RAS oncogene family
RAB40B RAB40B, member RAS oncogene family
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNF5 ring finger protein 5, E3 ubiquitin protein ligase
RTEL1 regulator of telomere elongation helicase 1
SCN5A sodium channel, voltage gated, type V alpha subunit
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SORBS3 sorbin and SH3 domain containing 3
SPDEF SAM pointed domain containing ETS transcription factor
STAB2 stabilin 2
STK11 serine/threonine kinase 11
TEX40 testis expressed 40
TFF1 trefoil factor 1
TMCC2 transmembrane and coiled-coil domain family 2
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial)
TRAPPC9 trafficking protein particle complex 9
TUBA4B tubulin, alpha 4b
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VGF VGF nerve growth factor inducible
WFDC8 WAP four-disulfide core domain 8
WISP2 WNT1 inducible signaling pathway protein 2
ZFHX2 zinc finger homeobox 2

decreased expression

Symbol Name
ACACA acetyl-CoA carboxylase alpha
APOC2 apolipoprotein C-II
ARL4A ADP-ribosylation factor-like 4A
ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
ASTE1 asteroid homolog 1 (Drosophila)
AVEN apoptosis, caspase activation inhibitor
BABAM1 BRISC and BRCA1 A complex member 1
BARD1 BRCA1 associated RING domain 1
BCL7B B-cell CLL/lymphoma 7B
C11ORF49 chromosome 11 open reading frame 49
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3
CCL2 chemokine (C-C motif) ligand 2
CDCA8 cell division cycle associated 8
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN15 claudin 15
COMMD9 COMM domain containing 9
CST7 cystatin F (leukocystatin)
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DPF2 D4, zinc and double PHD fingers family 2
ENDOG endonuclease G
FADS2 fatty acid desaturase 2
FKTN fukutin
FUCA1 fucosidase, alpha-L- 1, tissue
GAB2 GRB2-associated binding protein 2
GALE UDP-galactose-4-epimerase
GBAP1 glucosidase, beta, acid pseudogene 1
GIT2 G protein-coupled receptor kinase interacting ArfGAP 2
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
GOLGA3 golgin A3
GPS2 G protein pathway suppressor 2
ITFG1 integrin alpha FG-GAP repeat containing 1
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
KEAP1 kelch-like ECH-associated protein 1
KLF2 Kruppel-like factor 2
KLHL21 kelch-like family member 21
LAMP5 lysosomal-associated membrane protein family, member 5
LIG1 ligase I, DNA, ATP-dependent
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MCRS1 microspherule protein 1
MGMT O-6-methylguanine-DNA methyltransferase
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
MPV17 MpV17 mitochondrial inner membrane protein
MYLIP myosin regulatory light chain interacting protein
NADSYN1 NAD synthetase 1
NAGK N-acetylglucosamine kinase
NCF1C neutrophil cytosolic factor 1C pseudogene
NEU1 sialidase 1 (lysosomal sialidase)
NSUN5P1 NOP2/Sun domain family, member 5 pseudogene 1
NVL nuclear VCP-like
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
ORC1 origin recognition complex, subunit 1
OSGEPL1 O-sialoglycoprotein endopeptidase-like 1
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PAGR1 PAXIP1 associated glutamate-rich protein 1
PCTP phosphatidylcholine transfer protein
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PGS1 phosphatidylglycerophosphate synthase 1
PHKG2 phosphorylase kinase, gamma 2 (testis)
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PNRC1 proline-rich nuclear receptor coactivator 1
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PRKCD protein kinase C, delta
PRR3 proline rich 3
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTOV1 prostate tumor overexpressed 1
RAB4B RAB4B, member RAS oncogene family
RABEPK Rab9 effector protein with kelch motifs
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM10 RNA binding motif protein 10
RBM14 RNA binding motif protein 14
RNASE6 ribonuclease, RNase A family, k6
RWDD2B RWD domain containing 2B
SAC3D1 SAC3 domain containing 1
SCNM1 sodium channel modifier 1
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMG9 SMG9 nonsense mediated mRNA decay factor
SNX17 sorting nexin 17
SNX5 sorting nexin 5
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TEX264 testis expressed 264
TGFBRAP1 transforming growth factor, beta receptor associated protein 1
TMEM109 transmembrane protein 109
TTPAL tocopherol (alpha) transfer protein-like
TXLNA taxilin alpha
UBAC1 UBA domain containing 1
UBE2M ubiquitin-conjugating enzyme E2M
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae)
WDR6 WD repeat domain 6
WDR7 WD repeat domain 7
ZDHHC4 zinc finger, DHHC-type containing 4
ZNF33B zinc finger protein 33B
ZNF652 zinc finger protein 652