glibenclamide-5849 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the glibenclamide-5849 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ALDOB aldolase B, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
C1ORF54 chromosome 1 open reading frame 54
C8A complement component 8, alpha polypeptide
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CAPN10 calpain 10
CASS4 Cas scaffolding protein family member 4
CCT6B chaperonin containing TCP1, subunit 6B (zeta 2)
CDRT1 CMT1A duplicated region transcript 1
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
COL11A2 collagen, type XI, alpha 2
CROCC ciliary rootlet coiled-coil, rootletin
CSF1R colony stimulating factor 1 receptor
DDO D-aspartate oxidase
DTNA dystrobrevin, alpha
DYM dymeclin
EFNB3 ephrin-B3
EIF3F eukaryotic translation initiation factor 3, subunit F
EWSR1 EWS RNA-binding protein 1
EYA3 EYA transcriptional coactivator and phosphatase 3
FABP4 fatty acid binding protein 4, adipocyte
FLT4 fms-related tyrosine kinase 4
FNDC3A fibronectin type III domain containing 3A
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GNS glucosamine (N-acetyl)-6-sulfatase
GPRASP1 G protein-coupled receptor associated sorting protein 1
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HAPLN1 hyaluronan and proteoglycan link protein 1
HIST1H1T histone cluster 1, H1t
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
IDS iduronate 2-sulfatase
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1
KHK ketohexokinase (fructokinase)
LAMA4 laminin, alpha 4
LRP6 low density lipoprotein receptor-related protein 6
MAPK7 mitogen-activated protein kinase 7
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor)
MLANA melan-A
MMP10 matrix metallopeptidase 10
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae)
MSC musculin
MTRF1L mitochondrial translational release factor 1-like
MUC6 mucin 6, oligomeric mucus/gel-forming
NEUROD4 neuronal differentiation 4
NRF1 nuclear respiratory factor 1
PCDHGA10 protocadherin gamma subfamily A, 10
PDE4DIP phosphodiesterase 4D interacting protein
PDZK1 PDZ domain containing 1
PHLDA3 pleckstrin homology-like domain, family A, member 3
PKP3 plakophilin 3
PLIN2 perilipin 2
POU3F1 POU class 3 homeobox 1
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3
PPP1R7 protein phosphatase 1, regulatory subunit 7
PRKG2 protein kinase, cGMP-dependent, type II
PRLR prolactin receptor
PTPN1 protein tyrosine phosphatase, non-receptor type 1
QPCTL glutaminyl-peptide cyclotransferase-like
RAB28 RAB28, member RAS oncogene family
RAD51B RAD51 paralog B
RALGDS ral guanine nucleotide dissociation stimulator
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RCN3 reticulocalbin 3, EF-hand calcium binding domain
REEP1 receptor accessory protein 1
REM1 RAS (RAD and GEM)-like GTP-binding 1
RGS12 regulator of G-protein signaling 12
RNGTT RNA guanylyltransferase and 5'-phosphatase
ROM1 retinal outer segment membrane protein 1
RPL35A ribosomal protein L35a
RTN2 reticulon 2
RUNDC3B RUN domain containing 3B
SCAPER S-phase cyclin A-associated protein in the ER
SCN10A sodium channel, voltage gated, type X alpha subunit
SERGEF secretion regulating guanine nucleotide exchange factor
SEZ6L seizure related 6 homolog (mouse)-like
SIAH1 siah E3 ubiquitin protein ligase 1
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SMAD4 SMAD family member 4
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
STK3 serine/threonine kinase 3
STS steroid sulfatase (microsomal), isozyme S
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUN1 Sad1 and UNC84 domain containing 1
TBL1Y transducin (beta)-like 1, Y-linked
THRB thyroid hormone receptor, beta
TLE4 transducin-like enhancer of split 4
TMEM120B transmembrane protein 120B
TMEM53 transmembrane protein 53
TMEM8B transmembrane protein 8B
TSSK2 testis-specific serine kinase 2
TUBA4B tubulin, alpha 4b
TUBB2B tubulin, beta 2B class IIb
UBOX5 U-box domain containing 5
VAX2 ventral anterior homeobox 2
XYLB xylulokinase homolog (H. influenzae)
ZNF358 zinc finger protein 358

decreased expression

Symbol Name
ACADSB acyl-CoA dehydrogenase, short/branched chain
ACKR3 atypical chemokine receptor 3
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARSJ arylsulfatase family, member J
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BBS10 Bardet-Biedl syndrome 10
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide
BDNF brain-derived neurotrophic factor
BIRC3 baculoviral IAP repeat containing 3
C17ORF70 chromosome 17 open reading frame 70
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCDC106 coiled-coil domain containing 106
CDK9 cyclin-dependent kinase 9
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHEK2 checkpoint kinase 2
CHMP7 charged multivesicular body protein 7
CIR1 corepressor interacting with RBPJ, 1
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CLSPN claspin
COMMD10 COMM domain containing 10
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1
DDX31 DEAD (Asp-Glu-Ala-Asp) box polypeptide 31
DDX6 DEAD (Asp-Glu-Ala-Asp) box helicase 6
DGKD diacylglycerol kinase, delta 130kDa
ECM1 extracellular matrix protein 1
EGLN2 egl-9 family hypoxia-inducible factor 2
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
ERMAP erythroblast membrane-associated protein (Scianna blood group)
EVPL envoplakin
FOXA1 forkhead box A1
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPR1 G protein-coupled receptor 1
IRF2 interferon regulatory factor 2
JAM3 junctional adhesion molecule 3
JUP junction plakoglobin
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0894 KIAA0894 protein
KIAA1462 KIAA1462
KIRREL kin of IRRE like (Drosophila)
KLHL26 kelch-like family member 26
KLK6 kallikrein-related peptidase 6
LOC730101 uncharacterized LOC730101
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAP3K14 mitogen-activated protein kinase kinase kinase 14
MGC12488
MOSPD3 motile sperm domain containing 3
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
MVP major vault protein
NHLRC2 NHL repeat containing 2
NINL ninein-like
NPFFR1 neuropeptide FF receptor 1
NR3C2 nuclear receptor subfamily 3, group C, member 2
PDZD2 PDZ domain containing 2
PECR peroxisomal trans-2-enoyl-CoA reductase
PHACTR4 phosphatase and actin regulator 4
PIGL phosphatidylinositol glycan anchor biosynthesis, class L
PLAC8 placenta-specific 8
PLEKHO2 pleckstrin homology domain containing, family O member 2
PLK2 polo-like kinase 2
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PPP6R3 protein phosphatase 6, regulatory subunit 3
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
RAI2 retinoic acid induced 2
RCOR3 REST corepressor 3
RNH1 ribonuclease/angiogenin inhibitor 1
RPL23AP32 ribosomal protein L23a pseudogene 32
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
SH3BGR SH3 domain binding glutamate-rich protein
SHARPIN SHANK-associated RH domain interactor
SHPK sedoheptulokinase
SNX16 sorting nexin 16
SPATA2L spermatogenesis associated 2-like
SPATA7 spermatogenesis associated 7
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SSFA2 sperm specific antigen 2
ST5 suppression of tumorigenicity 5
STARD13 StAR-related lipid transfer (START) domain containing 13
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
TAGLN3 transgelin 3
TGIF1 TGFB-induced factor homeobox 1
THOC6 THO complex 6
TMEM156 transmembrane protein 156
TOR4A torsin family 4, member A
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
TRDMT1 tRNA aspartic acid methyltransferase 1
TRIM45 tripartite motif containing 45
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
ZBTB25 zinc finger and BTB domain containing 25
ZFAND3 zinc finger, AN1-type domain 3
ZMYM1 zinc finger, MYM-type 1
ZNF254 zinc finger protein 254
ZNF408 zinc finger protein 408
ZNF83 zinc finger protein 83
ZSCAN26 zinc finger and SCAN domain containing 26