glimepiride-2154 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the glimepiride-2154 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAMTSL4 ADAMTS-like 4
AFF4 AF4/FMR2 family, member 4
AMN amnion associated transmembrane protein
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AQP9 aquaporin 9
AURKA aurora kinase A
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CACNG1 calcium channel, voltage-dependent, gamma subunit 1
CASZ1 castor zinc finger 1
CD300A CD300a molecule
COL10A1 collagen, type X, alpha 1
CREM cAMP responsive element modulator
CRTC1 CREB regulated transcription coactivator 1
CSNK1G1 casein kinase 1, gamma 1
CTRC chymotrypsin C (caldecrin)
CXCR3 chemokine (C-X-C motif) receptor 3
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
DBNDD1 dysbindin (dystrobrevin binding protein 1) domain containing 1
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
ENG endoglin
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
EXOSC2 exosome component 2
F2RL3 coagulation factor II (thrombin) receptor-like 3
FAM110B family with sequence similarity 110, member B
FAM65A family with sequence similarity 65, member A
FANCA Fanconi anemia, complementation group A
FBXO2 F-box protein 2
FCAR Fc fragment of IgA receptor
FLRT1 fibronectin leucine rich transmembrane protein 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GAL3ST4 galactose-3-O-sulfotransferase 4
GPR3 G protein-coupled receptor 3
GPRC5C G protein-coupled receptor, class C, group 5, member C
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HPX hemopexin
IFI6 interferon, alpha-inducible protein 6
IGHA1 immunoglobulin heavy constant alpha 1
IL2RA interleukin 2 receptor, alpha
INHBA inhibin, beta A
IRF2BP1 interferon regulatory factor 2 binding protein 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KDM8 lysine (K)-specific demethylase 8
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1
KLHL36 kelch-like family member 36
LIN7B lin-7 homolog B (C. elegans)
LTA lymphotoxin alpha
LTBP1 latent transforming growth factor beta binding protein 1
MAP4 microtubule-associated protein 4
MED25 mediator complex subunit 25
MFAP3 microfibrillar-associated protein 3
MGLL monoglyceride lipase
MTRF1L mitochondrial translational release factor 1-like
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)
NIPAL2 NIPA-like domain containing 2
NNAT neuronatin
NOV nephroblastoma overexpressed
OR3A3 olfactory receptor, family 3, subfamily A, member 3
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PHLDB1 pleckstrin homology-like domain, family B, member 1
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PKD2L1 polycystic kidney disease 2-like 1
PLAC4 placenta-specific 4
PLSCR3 phospholipid scramblase 3
PLXNA3 plexin A3
PQLC2 PQ loop repeat containing 2
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PTPRB protein tyrosine phosphatase, receptor type, B
RAB6B RAB6B, member RAS oncogene family
RNASE3 ribonuclease, RNase A family, 3
S100A1 S100 calcium binding protein A1
SAMD4A sterile alpha motif domain containing 4A
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SIGLEC7 sialic acid binding Ig-like lectin 7
SLC15A3 solute carrier family 15 (oligopeptide transporter), member 3
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2
SLCO2B1 solute carrier organic anion transporter family, member 2B1
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPON1 spondin 1, extracellular matrix protein
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae)
SYN2 synapsin II
TACR2 tachykinin receptor 2
TCF3 transcription factor 3
TGM2 transglutaminase 2
TMC7 transmembrane channel-like 7
TMEM140 transmembrane protein 140
TSKS testis-specific serine kinase substrate
TSPAN14 tetraspanin 14
VCAN versican
WFDC8 WAP four-disulfide core domain 8
WRAP53 WD repeat containing, antisense to TP53
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZC3H7B zinc finger CCCH-type containing 7B
ZNF276 zinc finger protein 276
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
ACAD10 acyl-CoA dehydrogenase family, member 10
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
APBB1IP amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein
ARSB arylsulfatase B
ASTE1 asteroid homolog 1 (Drosophila)
ATAT1 alpha tubulin acetyltransferase 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
C11ORF68 chromosome 11 open reading frame 68
CAND2 cullin-associated and neddylation-dissociated 2 (putative)
CAPN5 calpain 5
CDA cytidine deaminase
CHM choroideremia (Rab escort protein 1)
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
DGAT1 diacylglycerol O-acyltransferase 1
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3
DNMBP dynamin binding protein
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EGR2 early growth response 2
ERN2 endoplasmic reticulum to nucleus signaling 2
FBP1 fructose-1,6-bisphosphatase 1
GAMT guanidinoacetate N-methyltransferase
GID4 GID complex subunit 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GRIP2 glutamate receptor interacting protein 2
GSR glutathione reductase
HIST1H2AJ histone cluster 1, H2aj
HIST1H4D histone cluster 1, H4d
HYAL2 hyaluronoglucosaminidase 2
IFT46 intraflagellar transport 46
IL22 interleukin 22
ISOC2 isochorismatase domain containing 2
KIAA0586 KIAA0586
LATS1 large tumor suppressor kinase 1
LOC729164 hCG1732469
LRP3 low density lipoprotein receptor-related protein 3
MANSC1 MANSC domain containing 1
MCTP2 multiple C2 domains, transmembrane 2
MKS1 Meckel syndrome, type 1
MTMR12 myotubularin related protein 12
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MX1 MX dynamin-like GTPase 1
MYOZ3 myozenin 3
NAT6 N-acetyltransferase 6 (GCN5-related)
NDE1 nudE neurodevelopment protein 1
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
NPFFR1 neuropeptide FF receptor 1
NRBP1 nuclear receptor binding protein 1
NTSR1 neurotensin receptor 1 (high affinity)
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PADI1 peptidyl arginine deiminase, type I
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLTP phospholipid transfer protein
PMP22 peripheral myelin protein 22
PODNL1 podocan-like 1
POR P450 (cytochrome) oxidoreductase
POTEKP POTE ankyrin domain family, member K, pseudogene
RAB17 RAB17, member RAS oncogene family
RAB23 RAB23, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RANBP17 RAN binding protein 17
RAP1GAP2 RAP1 GTPase activating protein 2
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain
SIL1 SIL1 nucleotide exchange factor
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SMA4 glucuronidase, beta pseudogene
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SNAI1 snail family zinc finger 1
SOX12 SRY (sex determining region Y)-box 12
SP4 Sp4 transcription factor
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TAGLN transgelin
TCTN1 tectonic family member 1
TCTN2 tectonic family member 2
TFF2 trefoil factor 2
THEM6 thioesterase superfamily member 6
TMEM120B transmembrane protein 120B
TMEM53 transmembrane protein 53
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TRIM25 tripartite motif containing 25
TRIM36 tripartite motif containing 36
TRIM45 tripartite motif containing 45
TSPAN5 tetraspanin 5
TUBA4B tubulin, alpha 4b
UNC93B1 unc-93 homolog B1 (C. elegans)
URM1 ubiquitin related modifier 1
YY2 YY2 transcription factor
ZC2HC1A zinc finger, C2HC-type containing 1A
ZIM2 zinc finger, imprinted 2
ZNF528 zinc finger protein 528
ZNF747 zinc finger protein 747
ZNF787 zinc finger protein 787