glioblastoma multiforme Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma). Two histologic variants are recognized: giant cell glioblastoma and gliosarcoma. (WHO)|Glial cell derived tumors arising from the optic nerve, usually presenting in childhood. Roughly 50% are associated with NEUROFIBROMATOSIS 1. Clinical manifestations include decreased visual acuity; EXOPHTHALMOS; NYSTAGMUS, PATHOLOGIC; STRABISMUS; pallor or swelling of the optic disc; and INTRACRANIAL HYPERTENSION. The tumor may extend into the optic chiasm and hypothalamus (MeSH).|A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures (MeSH).|A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures. (Experimental Factor Ontology, EFO_0000519)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:3068
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Genes

65 genes associated with the disease glioblastoma multiforme in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
APBA2 amyloid beta (A4) precursor protein-binding, family A, member 2 1.02476
USP10 ubiquitin specific peptidase 10 1.02476
KAT2B K(lysine) acetyltransferase 2B 1.00407
LINC00189 long intergenic non-protein coding RNA 189 0.986376
DCC DCC netrin 1 receptor 0.971169
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 0.960778
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.951514
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.947208
OGFRL1 opioid growth factor receptor-like 1 0.932777
FRMD8 FERM domain containing 8 0.93103
PCSK6 proprotein convertase subtilisin/kexin type 6 0.911472
IQSEC3 IQ motif and Sec7 domain 3 0.898875
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.896938
MAN1B1 mannosidase, alpha, class 1B, member 1 0.88094
SHROOM3 shroom family member 3 0.877977
LOC146513 uncharacterized LOC146513 0.877977
ZMYND15 zinc finger, MYND-type containing 15 0.871229
TTYH1 tweety family member 1 0.859451
LOC100507195 uncharacterized LOC100507195 0.857354
BTNL2 butyrophilin-like 2 0.84116
ALKBH6 alkB, alkylation repair homolog 6 (E. coli) 0.832379
DOCK1 dedicator of cytokinesis 1 0.826025
CLIP3 CAP-GLY domain containing linker protein 3 0.818753
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.815307
SCARB1 scavenger receptor class B, member 1 0.799531
PTPRO protein tyrosine phosphatase, receptor type, O 0.789217
PAQR5 progestin and adipoQ receptor family member V 0.788564
GPA33 glycoprotein A33 (transmembrane) 0.788239
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.783797
AIFM2 apoptosis-inducing factor, mitochondrion-associated, 2 0.780437
SP100 SP100 nuclear antigen 0.778649
GTSF1 gametocyte specific factor 1 0.769887
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.767882
FAM13A family with sequence similarity 13, member A 0.764659
DPH6 diphthamine biosynthesis 6 0.762941
MRPL23 mitochondrial ribosomal protein L23 0.754478
FOXP1 forkhead box P1 0.754478
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.748359
PPA2 pyrophosphatase (inorganic) 2 0.734059
DLG2 discs, large homolog 2 (Drosophila) 0.714752
PARK2 parkin RBR E3 ubiquitin protein ligase 0.712959
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 0.712564
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 0.711585
PITPNM3 PITPNM family member 3 0.711001
DOCK5 dedicator of cytokinesis 5 0.708319
CDH23 cadherin-related 23 0.705888
DGKI diacylglycerol kinase, iota 0.70172
TMEM222 transmembrane protein 222 0.701015
CEP128 centrosomal protein 128kDa 0.698242
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.692261
PKHD1 polycystic kidney and hepatic disease 1 (autosomal recessive) 0.691618
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 0.689868
AADACL3 arylacetamide deacetylase-like 3 0.688615
ARID1A AT rich interactive domain 1A (SWI-like) 0.682862
INSC inscuteable homolog (Drosophila) 0.681111
LOXHD1 lipoxygenase homology domains 1 0.678682
MARCH1 membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase 0.6784
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.676587
SLIT3 slit homolog 3 (Drosophila) 0.675623
MROH2A maestro heat-like repeat family member 2A 0.675077
RAI1 retinoic acid induced 1 0.674534
MTUS1 microtubule associated tumor suppressor 1 0.67239
ADGRB3 adhesion G protein-coupled receptor B3 0.672258
SASH1 SAM and SH3 domain containing 1 0.669747
ONECUT2 one cut homeobox 2 0.668936