glioma Gene Set

Dataset KEGG Pathways
Category structural or functional annotations
Type pathway
Description A primary or metastatic malignant neoplasm involving the brain or spinal cord. Representative examples include anaplastic astrocytoma, glioblastoma, anaplastic (malignant) meningioma, lymphoma, and metastatic carcinoma from another anatomic site.|Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas ( ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas ( OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle (MeSH). (Experimental Factor Ontology, EFO_0000326)
External Link http://www.genome.jp/kegg/pathway/hsa/hsa05214.html
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Genes

62 proteins participating in the glioma pathway from the KEGG Pathways dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ARAF A-Raf proto-oncogene, serine/threonine kinase
BRAF B-Raf proto-oncogene, serine/threonine kinase
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALM2 calmodulin 2 (phosphorylase kinase, delta)
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CALML3 calmodulin-like 3
CALML6 calmodulin-like 6
CAMK2A calcium/calmodulin-dependent protein kinase II alpha
CAMK2B calcium/calmodulin-dependent protein kinase II beta
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CCND1 cyclin D1
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
E2F1 E2F transcription factor 1
E2F2 E2F transcription factor 2
E2F3 E2F transcription factor 3
EGF epidermal growth factor
EGFR epidermal growth factor receptor
GRB2 growth factor receptor-bound protein 2
HRAS Harvey rat sarcoma viral oncogene homolog
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
KRAS Kirsten rat sarcoma viral oncogene homolog
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PRKCA protein kinase C, alpha
PRKCG protein kinase C, gamma
PTEN phosphatase and tensin homolog
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RB1 retinoblastoma 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SHC4 SHC (Src homology 2 domain containing) family, member 4
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
TGFA transforming growth factor, alpha
TP53 tumor protein p53