glipizide-6645 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the glipizide-6645 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAM11 ADAM metallopeptidase domain 11
ADAM22 ADAM metallopeptidase domain 22
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADAMTS7 ADAM metallopeptidase with thrombospondin type 1 motif, 7
ALDH1B1 aldehyde dehydrogenase 1 family, member B1
ALOXE3 arachidonate lipoxygenase 3
ATG3 autophagy related 3
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
B9D1 B9 protein domain 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2 B-cell CLL/lymphoma 2
BTBD18 BTB (POZ) domain containing 18
C8A complement component 8, alpha polypeptide
CACYBP calcyclin binding protein
CASP1 caspase 1, apoptosis-related cysteine peptidase
CD68 CD68 molecule
CHN2 chimerin 2
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLCN6 chloride channel, voltage-sensitive 6
COPE coatomer protein complex, subunit epsilon
CTIF CBP80/20-dependent translation initiation factor
DIAPH2-AS1 DIAPH2 antisense RNA 1
DLC1 DLC1 Rho GTPase activating protein
EDA ectodysplasin A
ENO3 enolase 3 (beta, muscle)
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
ESM1 endothelial cell-specific molecule 1
F5 coagulation factor V (proaccelerin, labile factor)
FAM110B family with sequence similarity 110, member B
FAM174B family with sequence similarity 174, member B
FBXO40 F-box protein 40
FGB fibrinogen beta chain
FLJ42627 uncharacterized LOC645644
FRMD1 FERM domain containing 1
FRMD8 FERM domain containing 8
FRMPD1 FERM and PDZ domain containing 1
FSTL3 follistatin-like 3 (secreted glycoprotein)
GC group-specific component (vitamin D binding protein)
GNRH2 gonadotropin-releasing hormone 2
GZMM granzyme M (lymphocyte met-ase 1)
HIST1H3E histone cluster 1, H3e
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMHB1 histocompatibility (minor) HB-1
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
ING4 inhibitor of growth family, member 4
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIAA1644 KIAA1644
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
LARGE like-glycosyltransferase
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
LINC00115 long intergenic non-protein coding RNA 115
MAP7D3 MAP7 domain containing 3
MBD2 methyl-CpG binding domain protein 2
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEP1B meprin A, beta
MFAP3L microfibrillar-associated protein 3-like
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MTRF1L mitochondrial translational release factor 1-like
NOVA2 neuro-oncological ventral antigen 2
NR1H4 nuclear receptor subfamily 1, group H, member 4
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PACRG PARK2 co-regulated
PAOX polyamine oxidase (exo-N4-amino)
PAX2 paired box 2
PCDHGB6 protocadherin gamma subfamily B, 6
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PENK proenkephalin
PEX5L peroxisomal biogenesis factor 5-like
PGAM2 phosphoglycerate mutase 2 (muscle)
PKD2L1 polycystic kidney disease 2-like 1
PKNOX2 PBX/knotted 1 homeobox 2
PLXND1 plexin D1
PRDX2 peroxiredoxin 2
PRKCQ protein kinase C, theta
PTPN1 protein tyrosine phosphatase, non-receptor type 1
RBBP9 retinoblastoma binding protein 9
RGS7 regulator of G-protein signaling 7
RIMS2 regulating synaptic membrane exocytosis 2
RPS6KA6 ribosomal protein S6 kinase, 90kDa, polypeptide 6
SARM1 sterile alpha and TIR motif containing 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLA Src-like-adaptor
SLC1A7 solute carrier family 1 (glutamate transporter), member 7
SLC22A7 solute carrier family 22 (organic anion transporter), member 7
SLC44A4 solute carrier family 44, member 4
SRGAP3 SLIT-ROBO Rho GTPase activating protein 3
TADA3 transcriptional adaptor 3
TDRD3 tudor domain containing 3
TLDC1 TBC/LysM-associated domain containing 1
TM4SF5 transmembrane 4 L six family member 5
TMEM231 transmembrane protein 231
TTLL3 tubulin tyrosine ligase-like family member 3
TUBA3C tubulin, alpha 3c
WNT2B wingless-type MMTV integration site family, member 2B
ZC3H7B zinc finger CCCH-type containing 7B
ZNF3 zinc finger protein 3
ZNF334 zinc finger protein 334
ZNF76 zinc finger protein 76
ZNF778 zinc finger protein 778

decreased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ACADSB acyl-CoA dehydrogenase, short/branched chain
ADTRP androgen-dependent TFPI-regulating protein
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ARHGAP12 Rho GTPase activating protein 12
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila)
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
ATAD5 ATPase family, AAA domain containing 5
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BBC3 BCL2 binding component 3
C10ORF88 chromosome 10 open reading frame 88
C3 complement component 3
C6ORF47 chromosome 6 open reading frame 47
CABYR calcium binding tyrosine-(Y)-phosphorylation regulated
CCDC85C coiled-coil domain containing 85C
CFAP69 cilia and flagella associated protein 69
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CIDEC cell death-inducing DFFA-like effector c
CLDN14 claudin 14
CLIC3 chloride intracellular channel 3
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CNIH3 cornichon family AMPA receptor auxiliary protein 3
CWF19L1 CWF19-like 1, cell cycle control (S. pombe)
DDIT3 DNA-damage-inducible transcript 3
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54
DNAH7 dynein, axonemal, heavy chain 7
DNAL4 dynein, axonemal, light chain 4
DTX2 deltex 2, E3 ubiquitin ligase
EDIL3 EGF-like repeats and discoidin I-like domains 3
EFNA3 ephrin-A3
ERAP2 endoplasmic reticulum aminopeptidase 2
FAM120C family with sequence similarity 120C
FBXL7 F-box and leucine-rich repeat protein 7
GAMT guanidinoacetate N-methyltransferase
GDAP1 ganglioside induced differentiation associated protein 1
GEMIN8 gem (nuclear organelle) associated protein 8
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNL1 guanine nucleotide binding protein-like 1
GRTP1 growth hormone regulated TBC protein 1
GSTCD glutathione S-transferase, C-terminal domain containing
HIST1H2AJ histone cluster 1, H2aj
HIST1H3G histone cluster 1, H3g
HLX H2.0-like homeobox
IFNA14 interferon, alpha 14
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
INPPL1 inositol polyphosphate phosphatase-like 1
IPO8 importin 8
KIF3A kinesin family member 3A
KLF7 Kruppel-like factor 7 (ubiquitous)
LINC00341 long intergenic non-protein coding RNA 341
LMTK1 lemur tail kinase 1
LPAR4 lysophosphatidic acid receptor 4
LY6G6C lymphocyte antigen 6 complex, locus G6C
LY96 lymphocyte antigen 96
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2
MB myoglobin
MBTD1 mbt domain containing 1
MGAT4A mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
MLYCD malonyl-CoA decarboxylase
NR1H3 nuclear receptor subfamily 1, group H, member 3
PACS1 phosphofurin acidic cluster sorting protein 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PRB3 proline-rich protein BstNI subfamily 3
PREX2 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PWAR5 Prader Willi/Angelman region RNA 5
RAB3A RAB3A, member RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RPP25 ribonuclease P/MRP 25kDa subunit
RUNX1-IT1 RUNX1 intronic transcript 1
SARS2 seryl-tRNA synthetase 2, mitochondrial
SAYSD1 SAYSVFN motif domain containing 1
SCIN scinderin
SENP7 SUMO1/sentrin specific peptidase 7
SERGEF secretion regulating guanine nucleotide exchange factor
SIRAL2 SIR2 antiphage like 2
SLC12A9 solute carrier family 12, member 9
SLC39A7 solute carrier family 39 (zinc transporter), member 7
STARD3 StAR-related lipid transfer (START) domain containing 3
STK16 serine/threonine kinase 16
STON1 stonin 1
STRN striatin, calmodulin binding protein
SYTL2 synaptotagmin-like 2
TADA2A transcriptional adaptor 2A
TH tyrosine hydroxylase
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TINAGL1 tubulointerstitial nephritis antigen-like 1
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TOM1 target of myb1 (chicken)
TRIM58 tripartite motif containing 58
ULBP2 UL16 binding protein 2
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
ZFP30 ZFP30 zinc finger protein
ZNF141 zinc finger protein 141
ZNF215 zinc finger protein 215
ZSCAN16 zinc finger and SCAN domain containing 16