glomerulosclerosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A glomerulonephritis that is characterized by hardening of the glomerulus in the kidney. (Human Disease Ontology, DOID_0050851)
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Genes

209 genes co-occuring with the disease glomerulosclerosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin) 2.56887
ACTN4 actinin, alpha 4 2.36079
NPHS1 nephrosis 1, congenital, Finnish type (nephrin) 2.10376
SYNPO synaptopodin 2.03606
TRPC6 transient receptor potential cation channel, subfamily C, member 6 1.9483
CD2AP CD2-associated protein 1.92342
INF2 inverted formin, FH2 and WH2 domain containing 1.92295
APOL1 apolipoprotein L, 1 1.83773
MYH9 myosin, heavy chain 9, non-muscle 1.69315
ALB albumin 1.67819
WT1 Wilms tumor 1 1.63724
PTPRO protein tyrosine phosphatase, receptor type, O 1.61575
MPV17 MpV17 mitochondrial inner membrane protein 1.45001
MYO1E myosin IE 1.43771
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B 1.29877
CD79A CD79a molecule, immunoglobulin-associated alpha 1.27911
ACE angiotensin I converting enzyme 1.27781
COL4A4 collagen, type IV, alpha 4 1.22172
GNS glucosamine (N-acetyl)-6-sulfatase 1.17722
PTPRU protein tyrosine phosphatase, receptor type, U 1.17164
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 1.17121
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 1.16735
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen) 1.1507
PLCE1 phospholipase C, epsilon 1 1.13839
FMN1 formin 1 1.09545
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 1.05303
CABIN1 calcineurin binding protein 1 0.979268
IGHA1 immunoglobulin heavy constant alpha 1 0.97128
PLEKHH2 pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 0.925452
KIRREL kin of IRRE like (Drosophila) 0.921736
TGFB1 transforming growth factor, beta 1 0.881472
ACTL7B actin-like 7B 0.874919
FBXL20 F-box and leucine-rich repeat protein 20 0.865093
UMOD uromodulin 0.851173
MIR192 microRNA 192 0.840525
SNRPB2 small nuclear ribonucleoprotein polypeptide B 0.831508
LAMA1 laminin, alpha 1 0.814693
EDA ectodysplasin A 0.814283
FRAT1 frequently rearranged in advanced T-cell lymphomas 1 0.786394
IGSF5 immunoglobulin superfamily, member 5 0.784345
ACTL7A actin-like 7A 0.745985
LRP2 low density lipoprotein receptor-related protein 2 0.741517
ALG13 ALG13, UDP-N-acetylglucosaminyltransferase subunit 0.709169
ADAM19 ADAM metallopeptidase domain 19 0.705547
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 0.695103
LYZ lysozyme 0.691495
KIRREL2 kin of IRRE like 2 (Drosophila) 0.689893
AMOTL1 angiomotin like 1 0.673917
PAX2 paired box 2 0.659611
SPATA21 spermatogenesis associated 21 0.65288
PLXNA1 plexin A1 0.640645
ACE2 angiotensin I converting enzyme 2 0.630027
CD68 CD68 molecule 0.624535
CASR calcium-sensing receptor 0.60264
SNF8 SNF8, ESCRT-II complex subunit 0.595233
NPNT nephronectin 0.590558
ARHGAP24 Rho GTPase activating protein 24 0.588222
SDK1 sidekick cell adhesion molecule 1 0.587054
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.586665
SHROOM3 shroom family member 3 0.578494
AFF2 AF4/FMR2 family, member 2 0.566443
HAT1 histone acetyltransferase 1 0.565277
LCN2 lipocalin 2 0.564112
PODXL podocalyxin-like 0.558674
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.558285
NXF5 nuclear RNA export factor 5 0.546644
EZR ezrin 0.542767
IQGAP1 IQ motif containing GTPase activating protein 1 0.541992
APOL2 apolipoprotein L, 2 0.538506
FN1 fibronectin 1 0.537344
TINAG tubulointerstitial nephritis antigen 0.536183
CDSN corneodesmosin 0.531541
COL4A5 collagen, type IV, alpha 5 0.519961
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.490072
THY1 Thy-1 cell surface antigen 0.487788
PGM1 phosphoglucomutase 1 0.487027
DCAF7 DDB1 and CUL4 associated factor 7 0.485125
NRP2 neuropilin 2 0.478668
EYA1 EYA transcriptional coactivator and phosphatase 1 0.474877
PDGFD platelet derived growth factor D 0.467684
LCA10 lung carcinoma-associated 10 0.463527
MN1 meningioma (disrupted in balanced translocation) 1 0.461639
CLCN5 chloride channel, voltage-sensitive 5 0.458241
C5ORF38 chromosome 5 open reading frame 38 0.457487
CLDN1 claudin 1 0.443547
PPOX protoporphyrinogen oxidase 0.440914
CLDN7 claudin 7 0.430017
WTIP Wilms tumor 1 interacting protein 0.428516
LY75 lymphocyte antigen 75 0.424765
BAIAP2 BAI1-associated protein 2 0.412031
KLF15 Kruppel-like factor 15 0.399334
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.398216
SALL2 spalt-like transcription factor 2 0.397471
PLAUR plasminogen activator, urokinase receptor 0.397098
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.396725
MAL mal, T-cell differentiation protein 0.393746
CD80 CD80 molecule 0.390769
SIX5 SIX homeobox 5 0.389281
CTSB cathepsin B 0.387423
ILK integrin-linked kinase 0.385193
CTGF connective tissue growth factor 0.383708
TPSG1 tryptase gamma 1 0.383337
CD4 CD4 molecule 0.381852
CD151 CD151 molecule (Raph blood group) 0.372587
NCK1 NCK adaptor protein 1 0.369997
LPL lipoprotein lipase 0.364085
EFNB1 ephrin-B1 0.364085
PLAU plasminogen activator, urokinase 0.363347
SPP1 secreted phosphoprotein 1 0.354868
PPAN-P2RY11 PPAN-P2RY11 readthrough 0.354499
P2RY11 purinergic receptor P2Y, G-protein coupled, 11 0.354499
C3 complement component 3 0.351555
COL8A1 collagen, type VIII, alpha 1 0.347511
UBC ubiquitin C 0.346777
KRT8 keratin 8, type II 0.345308
FGA fibrinogen alpha chain 0.344941
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 0.341272
PGC progastricsin (pepsinogen C) 0.340906
LMX1B LIM homeobox transcription factor 1, beta 0.339806
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.339806
RPS27A ribosomal protein S27a 0.337975
ELMO1 engulfment and cell motility 1 0.333218
CSNK2B casein kinase 2, beta polypeptide 0.331756
RAB23 RAB23, member RAS oncogene family 0.323365
BHLHE22 basic helix-loop-helix family, member e22 0.323002
SEBOX SEBOX homeobox 0.321545
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.319363
RARA retinoic acid receptor, alpha 0.315729
SIX1 SIX homeobox 1 0.313189
ACTN1 actinin, alpha 1 0.312102
CNOT2 CCR4-NOT transcription complex, subunit 2 0.31029
TMPRSS13 transmembrane protease, serine 13 0.31029
VLDLR very low density lipoprotein receptor 0.301254
COQ2 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase 0.300173
ECT2 epithelial cell transforming 2 0.299812
ROBO4 roundabout, axon guidance receptor, homolog 4 (Drosophila) 0.295492
JAG1 jagged 1 0.292975
UBB ubiquitin B 0.292975
DDIT3 DNA-damage-inducible transcript 3 0.29118
TBX1 T-box 1 0.289386
ANXA7 annexin A7 0.285802
PCNA proliferating cell nuclear antigen 0.275801
NES nestin 0.274021
NOTCH1 notch 1 0.272953
AMELY amelogenin, Y-linked 0.272597
TF transferrin 0.268687
TNF tumor necrosis factor 0.266913
CFHR5 complement factor H-related 5 0.259124
RAP1GAP RAP1 GTPase activating protein 0.25877
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 0.258064
REN renin 0.255594
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.251366
B2M beta-2-microglobulin 0.251015
MME membrane metallo-endopeptidase 0.251015
PON1 paraoxonase 1 0.251015
DNAI1 dynein, axonemal, intermediate chain 1 0.245396
AMELX amelogenin, X-linked 0.243295
SCARB2 scavenger receptor class B, member 2 0.240847
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.235616
XPR1 xenotropic and polytropic retrovirus receptor 1 0.234225
HAVCR1 hepatitis A virus cellular receptor 1 0.232489
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 0.230063
CDC42 cell division cycle 42 0.224884
TAGLN transgelin 0.218374
PIAS1 protein inhibitor of activated STAT, 1 0.217012
DPEP1 dipeptidase 1 (renal) 0.217012
PARK7 parkinson protein 7 0.216672
TRPM6 transient receptor potential cation channel, subfamily M, member 6 0.214975
ANK3 ankyrin 3, node of Ranvier (ankyrin G) 0.212945
AGTR1 angiotensin II receptor, type 1 0.209248
NOTCH2 notch 2 0.208914
CKM creatine kinase, muscle 0.207245
CD44 CD44 molecule (Indian blood group) 0.20658
NOTCH2NL notch 2 N-terminal like 0.20658
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.205585
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) 0.205254
COL8A2 collagen, type VIII, alpha 2 0.202946
NGDN neuroguidin, EIF4E binding protein 0.19742
ZYX zyxin 0.19742
MAPK1 mitogen-activated protein kinase 1 0.194865
TIMP1 TIMP metallopeptidase inhibitor 1 0.1936
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 0.192657
NPHP4 nephronophthisis 4 0.192031
SMAD3 SMAD family member 3 0.187113
THEM5 thioesterase superfamily member 5 0.186811
TIMP2 TIMP metallopeptidase inhibitor 2 0.186811
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase 0.186811
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.185612
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) 0.181798
STOM stomatin 0.177851
DNM2 dynamin 2 0.177576
RNASEH2A ribonuclease H2, subunit A 0.176215
NRP1 neuropilin 1 0.175947
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 0.175411
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.174354
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.172038
FSCN1 fascin actin-bundling protein 1 0.171785
C1S complement component 1, s subcomponent 0.170299
PIAS3 protein inhibitor of activated STAT, 3 0.167224
OPTN optineurin 0.166319
DPAGT1 dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) 0.165874
SDC2 syndecan 2 0.165874
SMAD6 SMAD family member 6 0.163729
PLCH2 phospholipase C, eta 2 0.161331
ICAM1 intercellular adhesion molecule 1 0.160761
ADAM17 ADAM metallopeptidase domain 17 0.160761
IL10 interleukin 10 0.158951
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 0.158097
SMAD7 SMAD family member 7 0.157765