glomerulosclerosis Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE. (Experimental Factor Ontology, EFO_0004236)
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Genes

70 genes co-occuring with the biological term glomerulosclerosis in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ACE angiotensin I converting enzyme
ACTN4 actinin, alpha 4
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
APOE apolipoprotein E
APOL1 apolipoprotein L, 1
ARHGAP24 Rho GTPase activating protein 24
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
C5 complement component 5
CCL2 chemokine (C-C motif) ligand 2
CD2AP CD2-associated protein
CD80 CD80 molecule
CLDN1 claudin 1
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COL4A4 collagen, type IV, alpha 4
COL4A5 collagen, type IV, alpha 5
CTGF connective tissue growth factor
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
EYA1 EYA transcriptional coactivator and phosphatase 1
FN1 fibronectin 1
GH1 growth hormone 1
GIPR gastric inhibitory polypeptide receptor
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GREM1 gremlin 1, DAN family BMP antagonist
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IL10 interleukin 10
IL6 interleukin 6
ILK integrin-linked kinase
INF2 inverted formin, FH2 and WH2 domain containing
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
LAMB2 laminin, beta 2 (laminin S)
LCN2 lipocalin 2
LMX1B LIM homeobox transcription factor 1, beta
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MET MET proto-oncogene, receptor tyrosine kinase
MIR186 microRNA 186
MIR30A microRNA 30a
MLXIPL MLX interacting protein-like
MYH9 myosin, heavy chain 9, non-muscle
MYO1E myosin IE
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPHS2 nephrosis 2, idiopathic, steroid-resistant (podocin)
NPNT nephronectin
NXF5 nuclear RNA export factor 5
PAX2 paired box 2
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PLAUR plasminogen activator, urokinase receptor
PLCE1 phospholipase C, epsilon 1
PODXL podocalyxin-like
PTPRU protein tyrosine phosphatase, receptor type, U
RAP1GAP RAP1 GTPase activating protein
S100A4 S100 calcium binding protein A4
SCARB2 scavenger receptor class B, member 2
SDK1 sidekick cell adhesion molecule 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
SMAD1 SMAD family member 1
SMAD2 SMAD family member 2
SMAD3 SMAD family member 3
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SYNPO synaptopodin
TGFB1 transforming growth factor, beta 1
TNF tumor necrosis factor
TRPC6 transient receptor potential cation channel, subfamily C, member 6
VEGFA vascular endothelial growth factor A
WT1 Wilms tumor 1