glucocorticoid-induced osteoporosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
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Genes

185 genes co-occuring with the disease glucocorticoid-induced osteoporosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 3.049
BGLAP bone gamma-carboxyglutamate (gla) protein 3.006
PTH parathyroid hormone 2.879
SOST sclerostin 2.87
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 2.827
RUNX2 runt-related transcription factor 2 2.757
ACP5 acid phosphatase 5, tartrate resistant 2.665
SP7 Sp7 transcription factor 2.517
CTSK cathepsin K 2.479
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.388
BMP2 bone morphogenetic protein 2 2.311
LRP5 low density lipoprotein receptor-related protein 5 2.236
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 2.167
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 2.164
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.069
IGF1 insulin-like growth factor 1 (somatomedin C) 1.997
SPP1 secreted phosphoprotein 1 1.995
ESR1 estrogen receptor 1 1.991
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.951
FDPS farnesyl diphosphate synthase 1.947
WNT10B wingless-type MMTV integration site family, member 10B 1.918
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.895
COL1A1 collagen, type I, alpha 1 1.846
IL6 interleukin 6 1.836
PTHLH parathyroid hormone-like hormone 1.832
TNF tumor necrosis factor 1.821
PTH1R parathyroid hormone 1 receptor 1.81
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.802
IBSP integrin-binding sialoprotein 1.782
COL1A2 collagen, type I, alpha 2 1.772
GSK3B glycogen synthase kinase 3 beta 1.763
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.721
ALPL alkaline phosphatase, liver/bone/kidney 1.719
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.718
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.716
IL1B interleukin 1, beta 1.71
FGF23 fibroblast growth factor 23 1.708
PPARG peroxisome proliferator-activated receptor gamma 1.701
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.688
WNT3A wingless-type MMTV integration site family, member 3A 1.667
WNT16 wingless-type MMTV integration site family, member 16 1.665
FOS FBJ murine osteosarcoma viral oncogene homolog 1.649
SFRP1 secreted frizzled-related protein 1 1.646
LRP6 low density lipoprotein receptor-related protein 6 1.641
TGFB1 transforming growth factor, beta 1 1.631
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.607
CSF1 colony stimulating factor 1 (macrophage) 1.598
MMP13 matrix metallopeptidase 13 1.588
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.578
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.577
DMP1 dentin matrix acidic phosphoprotein 1 1.573
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.562
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.562
IL1A interleukin 1, alpha 1.559
TSC22D3 TSC22 domain family, member 3 1.536
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 1.534
EMCN endomucin 1.528
PLEKHO1 pleckstrin homology domain containing, family O member 1 1.506
IL17A interleukin 17A 1.462
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.455
ALPG alkaline phosphatase, germ cell 1.447
DCSTAMP dendrocyte expressed seven transmembrane protein 1.444
POMC proopiomelanocortin 1.434
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.433
ALPI alkaline phosphatase, intestinal 1.417
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1 1.413
INS insulin 1.412
SIRT1 sirtuin 1 1.41
WNT1 wingless-type MMTV integration site family, member 1 1.406
GPX4 glutathione peroxidase 4 1.403
LEP leptin 1.401
MMP9 matrix metallopeptidase 9 1.399
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.39
TRPV6 transient receptor potential cation channel, subfamily V, member 6 1.386
ACTB actin, beta 1.377
ALB albumin 1.376
ALPP alkaline phosphatase, placental 1.373
ZNF225 zinc finger protein 225 1.372
IL11 interleukin 11 1.369
GGPS1 geranylgeranyl diphosphate synthase 1 1.365
HMOX1 heme oxygenase 1 1.358
FOXO1 forkhead box O1 1.351
DKK4 dickkopf WNT signaling pathway inhibitor 4 1.349
CCK cholecystokinin 1.349
ITGA10 integrin, alpha 10 1.346
JUN jun proto-oncogene 1.33
AXIN1 axin 1 1.324
CALCR calcitonin receptor 1.307
DKK2 dickkopf WNT signaling pathway inhibitor 2 1.307
DLX5 distal-less homeobox 5 1.305
BMP7 bone morphogenetic protein 7 1.301
PHEX phosphate regulating endopeptidase homolog, X-linked 1.296
BECN1 beclin 1, autophagy related 1.275
S100G S100 calcium binding protein G 1.272
IFNG interferon, gamma 1.272
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.268
BCL2 B-cell CLL/lymphoma 2 1.256
WNT7B wingless-type MMTV integration site family, member 7B 1.251
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.24
KL klotho 1.235
CASR calcium-sensing receptor 1.227
FBXO9 F-box protein 9 1.226
FGF2 fibroblast growth factor 2 (basic) 1.224
CRP C-reactive protein, pentraxin-related 1.219
OGN osteoglycin 1.217
GDF2 growth differentiation factor 2 1.216
WIF1 WNT inhibitory factor 1 1.213
FOXO3 forkhead box O3 1.209
NOG noggin 1.206
WNT5B wingless-type MMTV integration site family, member 5B 1.199
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.199
MEPE matrix extracellular phosphoglycoprotein 1.197
THY1 Thy-1 cell surface antigen 1.195
HDAC4 histone deacetylase 4 1.191
PXDNL peroxidasin-like 1.184
GC group-specific component (vitamin D binding protein) 1.184
PXDN peroxidasin 1.183
IL10 interleukin 10 1.183
KREMEN1 kringle containing transmembrane protein 1 1.179
WNT5A wingless-type MMTV integration site family, member 5A 1.178
MAPK3 mitogen-activated protein kinase 3 1.178
SOX9 SRY (sex determining region Y)-box 9 1.175
BMP4 bone morphogenetic protein 4 1.175
XYLT2 xylosyltransferase II 1.167
ZNF234 zinc finger protein 234 1.166
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 1.147
OSCAR osteoclast associated, immunoglobulin-like receptor 1.145
ATF4 activating transcription factor 4 1.135
REN renin 1.132
MSTN myostatin 1.131
CRH corticotropin releasing hormone 1.122
BAX BCL2-associated X protein 1.12
CXCL12 chemokine (C-X-C motif) ligand 12 1.12
FGF18 fibroblast growth factor 18 1.12
ADIPOQ adiponectin, C1Q and collagen domain containing 1.107
ESR2 estrogen receptor 2 (ER beta) 1.107
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.103
ATG5 autophagy related 5 1.102
ACE angiotensin I converting enzyme 1.1
FGF17 fibroblast growth factor 17 1.092
TP53 tumor protein p53 1.09
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 1.088
OCSTAMP osteoclast stimulatory transmembrane protein 1.087
IL2 interleukin 2 1.081
IL4 interleukin 4 1.08
CAB39 calcium binding protein 39 1.079
FST follistatin 1.071
CCND1 cyclin D1 1.071
COL2A1 collagen, type II, alpha 1 1.069
FRZB frizzled-related protein 1.063
FGF7 fibroblast growth factor 7 1.061
FBXO32 F-box protein 32 1.06
PTPRC protein tyrosine phosphatase, receptor type, C 1.06
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.059
FGF4 fibroblast growth factor 4 1.057
FGF5 fibroblast growth factor 5 1.056
CD34 CD34 molecule 1.053
MMP3 matrix metallopeptidase 3 1.051
FGF3 fibroblast growth factor 3 1.05
SMAD5 SMAD family member 5 1.049
FGF22 fibroblast growth factor 22 1.048
FGF16 fibroblast growth factor 16 1.047
FGF6 fibroblast growth factor 6 1.046
UBXN11 UBX domain protein 11 1.045
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.045
FGF20 fibroblast growth factor 20 1.044
INSR insulin receptor 1.04
CXCL8 chemokine (C-X-C motif) ligand 8 1.039
FGF10 fibroblast growth factor 10 1.036
OSTN osteocrin 1.035
NOL9 nucleolar protein 9 1.03
FGF9 fibroblast growth factor 9 1.029
GPX5 glutathione peroxidase 5 1.028
FGF8 fibroblast growth factor 8 (androgen-induced) 1.024
PIEZO1 piezo-type mechanosensitive ion channel component 1 1.023
PLXNB2 plexin B2 1.018
DUSP1 dual specificity phosphatase 1 1.017
PECAM1 platelet/endothelial cell adhesion molecule 1 1.017
NR3C2 nuclear receptor subfamily 3, group C, member 2 1.017
ENG endoglin 1.016
GPX6 glutathione peroxidase 6 1.012
GPX8 glutathione peroxidase 8 (putative) 1.011
CSF1R colony stimulating factor 1 receptor 1.008
GPX7 glutathione peroxidase 7 1.008
GPX3 glutathione peroxidase 3 1.007