glucocorticoid-remediable aldosteronism Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description OMIM mapping confirmed by DO. [SN]. (Human Disease Ontology, DOID_14080)
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Genes

143 genes co-occuring with the disease glucocorticoid-remediable aldosteronism in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 3.324
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 3.201
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 2.936
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 2.795
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 2.606
REN renin 2.535
POMC proopiomelanocortin 2.526
NR3C2 nuclear receptor subfamily 3, group C, member 2 2.423
PRF1 perforin 1 (pore forming protein) 2.395
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.38
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 2.372
CLCN2 chloride channel, voltage-sensitive 2 2.346
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 2.341
NOL9 nucleolar protein 9 2.336
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 2.284
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 2.2
TSC22D3 TSC22 domain family, member 3 2.177
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 2.133
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 2.126
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 2.005
WNK4 WNK lysine deficient protein kinase 4 1.989
FKBP5 FK506 binding protein 5 1.968
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 1.963
FKBP4 FK506 binding protein 4, 59kDa 1.948
SCNN1G sodium channel, non voltage gated 1 gamma subunit 1.892
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.879
SCNN1B sodium channel, non voltage gated 1 beta subunit 1.829
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1 1.814
WNK1 WNK lysine deficient protein kinase 1 1.798
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 1.791
ARMC5 armadillo repeat containing 5 1.791
HSD11B1 hydroxysteroid (11-beta) dehydrogenase 1 1.782
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 1.771
GZMK granzyme K (granzyme 3; tryptase II) 1.758
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 1.703
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 1.694
KLHL3 kelch-like family member 3 1.689
CRH corticotropin releasing hormone 1.674
CD8A CD8a molecule 1.658
ADD1 adducin 1 (alpha) 1.639
GNLY granulysin 1.634
RAB3IL1 RAB3A interacting protein (rabin3)-like 1 1.606
SGK1 serum/glucocorticoid regulated kinase 1 1.596
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 1.594
FASLG Fas ligand (TNF superfamily, member 6) 1.555
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 1.55
IL2 interleukin 2 1.537
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.536
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 1.517
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 1.501
LGALS4 lectin, galactoside-binding, soluble, 4 1.486
IFNG interferon, gamma 1.482
GMEB1 glucocorticoid modulatory element binding protein 1 1.479
TNF tumor necrosis factor 1.465
CD4 CD4 molecule 1.46
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 1.459
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3 1.455
GZMM granzyme M (lymphocyte met-ase 1) 1.423
ACE angiotensin I converting enzyme 1.418
STAR steroidogenic acute regulatory protein 1.414
SCNN1A sodium channel, non voltage gated 1 alpha subunit 1.353
IL6 interleukin 6 1.333
PDE3A phosphodiesterase 3A, cGMP-inhibited 1.315
HSPA4 heat shock 70kDa protein 4 1.298
PRKACA protein kinase, cAMP-dependent, catalytic, alpha 1.292
LAMP1 lysosomal-associated membrane protein 1 1.292
AGTR1 angiotensin II receptor, type 1 1.287
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 1.286
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 1.278
DUSP1 dual specificity phosphatase 1 1.276
IL1B interleukin 1, beta 1.269
KLRK1 killer cell lectin-like receptor subfamily K, member 1 1.254
EOMES eomesodermin 1.252
IL10 interleukin 10 1.25
HSD11B1L hydroxysteroid (11-beta) dehydrogenase 1-like 1.236
CD28 CD28 molecule 1.232
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 1.23
NCAM1 neural cell adhesion molecule 1 1.223
GCGR glucagon receptor 1.202
KLRC2 killer cell lectin-like receptor subfamily C, member 2 1.196
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.195
CREB1 cAMP responsive element binding protein 1 1.189
ASIC2 acid sensing (proton gated) ion channel 2 1.181
GLS2 glutaminase 2 (liver, mitochondrial) 1.171
DNAH8 dynein, axonemal, heavy chain 8 1.17
ADRB2 adrenoceptor beta 2, surface 1.17
NR0B1 nuclear receptor subfamily 0, group B, member 1 1.168
IL4 interleukin 4 1.163
GPR162 G protein-coupled receptor 162 1.162
KLRC1 killer cell lectin-like receptor subfamily C, member 1 1.159
KCNK9 potassium channel, two pore domain subfamily K, member 9 1.153
TBX21 T-box 21 1.153
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 1.152
NCOR1 nuclear receptor corepressor 1 1.152
PRKACG protein kinase, cAMP-dependent, catalytic, gamma 1.152
IL17A interleukin 17A 1.146
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.143
GMEB2 glucocorticoid modulatory element binding protein 2 1.138
VSNL1 visinin-like 1 1.136
HDAC2 histone deacetylase 2 1.135
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 1.133
ADD2 adducin 2 (beta) 1.13
NCR3 natural cytotoxicity triggering receptor 3 1.126
ZMIZ2 zinc finger, MIZ-type containing 2 1.124
NELFB negative elongation factor complex member B 1.115
CD27 CD27 molecule 1.113
ELL elongation factor RNA polymerase II 1.112
GORASP2 golgi reassembly stacking protein 2, 55kDa 1.108
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.106
FOXP3 forkhead box P3 1.104
CUL3 cullin 3 1.102
RPF1 ribosome production factor 1 homolog (S. cerevisiae) 1.101
CCR7 chemokine (C-C motif) receptor 7 1.098
NPPA natriuretic peptide A 1.093
USP40 ubiquitin specific peptidase 40 1.092
PHLDA2 pleckstrin homology-like domain, family A, member 2 1.088
PDE8B phosphodiesterase 8B 1.086
CTSC cathepsin C 1.084
LHCGR luteinizing hormone/choriogonadotropin receptor 1.083
NR1H2 nuclear receptor subfamily 1, group H, member 2 1.083
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 1.08
ALB albumin 1.068
INS insulin 1.065
ARHGAP36 Rho GTPase activating protein 36 1.063
TEAD4 TEA domain family member 4 1.057
NCR1 natural cytotoxicity triggering receptor 1 1.056
ADD3 adducin 3 (gamma) 1.055
IPO13 importin 13 1.051
MEN1 multiple endocrine neoplasia I 1.05
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.05
ANXA1 annexin A1 1.05
FOS FBJ murine osteosarcoma viral oncogene homolog 1.048
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 1.047
GLS glutaminase 1.045
GHRH growth hormone releasing hormone 1.043
WDR6 WD repeat domain 6 1.036
NUP62 nucleoporin 62kDa 1.031
B3GAT1 beta-1,3-glucuronyltransferase 1 1.027
KCNK3 potassium channel, two pore domain subfamily K, member 3 1.022
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.02
BCL2 B-cell CLL/lymphoma 2 1.017
PDE11A phosphodiesterase 11A 1.014
PKD2L1 polycystic kidney disease 2-like 1 1.0