glutathione metabolic process Gene Set

Dataset GO Biological Process Annotations 2025
Category structural or functional annotations
Type biological process
Description The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle. (Gene Ontology, GO_0006749)
External Link http://amigo.geneontology.org/amigo/term/GO:0006749
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Genes

39 genes participating in the glutathione metabolic process biological process from the curated GO Biological Process Annotations 2025 dataset.

Symbol Name
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHAC2 ChaC, cation transport regulator homolog 2 (E. coli)
CTNS cystinosin, lysosomal cystine transporter
DPEP1 dipeptidase 1 (renal)
ETHE1 ethylmalonic encephalopathy 1
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GGT1 gamma-glutamyltransferase 1
GGT5 gamma-glutamyltransferase 5
GGT7 gamma-glutamyltransferase 7
GLRX2 glutaredoxin 2
GPX1 glutathione peroxidase 1
GSR glutathione reductase
GSTA1 glutathione S-transferase alpha 1
GSTA2 glutathione S-transferase alpha 2
GSTA3 glutathione S-transferase alpha 3
GSTA4 glutathione S-transferase alpha 4
GSTA5 glutathione S-transferase alpha 5
GSTK1 glutathione S-transferase kappa 1
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTM3 glutathione S-transferase mu 3 (brain)
GSTM4 glutathione S-transferase mu 4
GSTM5 glutathione S-transferase mu 5
GSTO1 glutathione S-transferase omega 1
GSTO2 glutathione S-transferase omega 2
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene)
GSTT4 glutathione S-transferase theta 4
GSTZ1 glutathione S-transferase zeta 1
HAGH hydroxyacylglutathione hydrolase
HPGDS hematopoietic prostaglandin D synthase
MGST2 microsomal glutathione S-transferase 2
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria
OPLAH 5-oxoprolinase (ATP-hydrolysing)
SOD1 superoxide dismutase 1, soluble
UBL4A ubiquitin-like 4A