goiter Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Enlargement of the THYROID GLAND that may increase from about 20 grams to hundreds of grams in human adults. Goiter is observed in individuals with normal thyroid function (euthyroidism), thyroid deficiency ( HYPOTHYROIDISM), or hormone overproduction ( HYPERTHYROIDISM). Goiter may be congenital or acquired, sporadic or endemic ( GOITER, ENDEMIC). (Experimental Factor Ontology, EFO_0004283)
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Genes

285 genes co-occuring with the disease goiter in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
TG thyroglobulin 2.94864
TRH thyrotropin-releasing hormone 2.29774
SLC26A4 solute carrier family 26 (anion exchanger), member 4 2.26744
TPO thyroid peroxidase 2.25478
TSHR thyroid stimulating hormone receptor 2.0581
THRB thyroid hormone receptor, beta 1.76864
TXNRD2 thioredoxin reductase 2 1.73687
CALCA calcitonin-related polypeptide alpha 1.68453
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7 1.51062
PTH parathyroid hormone 1.46891
SLC5A8 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8 1.33807
LGALS3 lectin, galactoside-binding, soluble, 3 1.33109
TSHB thyroid stimulating hormone, beta 1.17121
IYD iodotyrosine deiodinase 1.1588
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5 1.10931
DUOX2 dual oxidase 2 1.08076
IGF1 insulin-like growth factor 1 (somatomedin C) 1.0753
RET ret proto-oncogene 1.07194
DUOXA2 dual oxidase maturation factor 2 0.986428
PRL prolactin 0.944521
BGLAP bone gamma-carboxyglutamate (gla) protein 0.870415
GRPEL1 GrpE-like 1, mitochondrial (E. coli) 0.817565
PAX8 paired box 8 0.815924
ALPP alkaline phosphatase, placental 0.784755
NKX2-1 NK2 homeobox 1 0.778204
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.778204
ALPPL2 alkaline phosphatase, placental-like 2 0.770844
ALPL alkaline phosphatase, liver/bone/kidney 0.769618
SERINC5 serine incorporator 5 0.766351
SHBG sex hormone-binding globulin 0.764718
SHFM1 split hand/foot malformation (ectrodactyly) type 1 0.743547
KRT19 keratin 19, type I 0.695103
SST somatostatin 0.684692
DICER1 dicer 1, ribonuclease type III 0.671527
GJB2 gap junction protein, beta 2, 26kDa 0.653276
ICAM1 intercellular adhesion molecule 1 0.622575
DYNLT1 dynein, light chain, Tctex-type 1 0.615529
RNH1 ribonuclease/angiogenin inhibitor 1 0.612792
PTEN phosphatase and tensin homolog 0.606543
LYPD1 LY6/PLAUR domain containing 1 0.605762
CCDC6 coiled-coil domain containing 6 0.59991
RGS12 regulator of G-protein signaling 12 0.59874
QPCTL glutaminyl-peptide cyclotransferase-like 0.59874
FASLG Fas ligand (TNF superfamily, member 6) 0.595623
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 0.594843
ZCCHC12 zinc finger, CCHC domain containing 12 0.58433
PAAF1 proteasomal ATPase-associated factor 1 0.579272
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 0.57305
PCNA proliferating cell nuclear antigen 0.56722
DIO2 deiodinase, iodothyronine, type II 0.565277
IL1B interleukin 1, beta 0.551686
LPO lactoperoxidase 0.543542
ALB albumin 0.514571
RHPN2 rhophilin, Rho GTPase binding protein 2 0.502675
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) 0.502675
LRP2 low density lipoprotein receptor-related protein 2 0.499997
IL6 interleukin 6 0.495793
TGFB1 transforming growth factor, beta 1 0.489311
CERS5 ceramide synthase 5 0.485505
DUOXA1 dual oxidase maturation factor 1 0.475255
GPX1 glutathione peroxidase 1 0.474119
BMP8A bone morphogenetic protein 8a 0.471468
GPX5 glutathione peroxidase 5 0.454093
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 0.452962
GPX4 glutathione peroxidase 4 0.451078
CLIC6 chloride intracellular channel 6 0.450701
GNAS GNAS complex locus 0.449947
TTR transthyretin 0.448441
IRX5 iroquois homeobox 5 0.445052
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.4443
UNG uracil-DNA glycosylase 0.443547
CD4 CD4 molecule 0.443547
HLA-C major histocompatibility complex, class I, C 0.435651
SNAI3 snail family zinc finger 3 0.431894
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 0.42739
ABR active BCR-related 0.42139
LIN52 lin-52 DREAM MuvB core complex component 0.419142
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 0.41727
ADCY2 adenylate cyclase 2 (brain) 0.415773
TDG thymine-DNA glycosylase 0.415398
IRX4 iroquois homeobox 4 0.410161
THRA thyroid hormone receptor, alpha 0.403811
PICALM phosphatidylinositol binding clathrin assembly protein 0.393374
INS insulin 0.392257
CTLA4 cytotoxic T-lymphocyte-associated protein 4 0.389281
EFTUD1 elongation factor Tu GTP binding domain containing 1 0.385565
KCNE5 potassium channel, voltage gated subfamily E regulatory beta subunit 5 0.382966
GMPS guanine monphosphate synthase 0.381852
AUH AU RNA binding protein/enoyl-CoA hydratase 0.38111
LRRN1 leucine rich repeat neuronal 1 0.374809
THEM5 thioesterase superfamily member 5 0.374809
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.370368
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.364824
IL1A interleukin 1, alpha 0.362978
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 0.360395
C8ORF4 chromosome 8 open reading frame 4 0.359657
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.357077
LGALS1 lectin, galactoside-binding, soluble, 1 0.356341
POMC proopiomelanocortin 0.352291
VILL villin-like 0.342372
ABHD16A abhydrolase domain containing 16A 0.337975
B3GAT1 beta-1,3-glucuronyltransferase 1 0.335046
CYS1 cystin 1 0.332487
SULT1A3 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 0.332121
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.327375
DUOX1 dual oxidase 1 0.32373
TNS1 tensin 1 0.322637
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.321545
HBA2 hemoglobin, alpha 2 0.318635
GPR39 G protein-coupled receptor 39 0.316819
ADAT2 adenosine deaminase, tRNA-specific 2 0.312464
GCOM1 GRINL1A complex locus 1 0.311739
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 0.307033
RLN2 relaxin 2 0.305587
FOS FBJ murine osteosarcoma viral oncogene homolog 0.304864
CXCL10 chemokine (C-X-C motif) ligand 10 0.304503
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.300533
VEGFA vascular endothelial growth factor A 0.298731
PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki) 0.298371
MEN1 multiple endocrine neoplasia I 0.297291
KALRN kalirin, RhoGEF kinase 0.292975
CPSF3L cleavage and polyadenylation specific factor 3-like 0.291898
IL2 interleukin 2 0.289744
GHRL ghrelin/obestatin prepropeptide 0.287593
IRX1 iroquois homeobox 1 0.287235
CP ceruloplasmin (ferroxidase) 0.286519
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 0.286519
PRSS3 protease, serine, 3 0.286519
HRAS Harvey rat sarcoma viral oncogene homolog 0.278654
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.277227
F8 coagulation factor VIII, procoagulant component 0.276514
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.274376
PRAMEF12 PRAME family member 12 0.271174
TF transferrin 0.264785
RASSF3 Ras association (RalGDS/AF-6) domain family member 3 0.264431
FLNB filamin B, beta 0.261599
SNN stannin 0.25983
CD79A CD79a molecule, immunoglobulin-associated alpha 0.256652
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.256299
FOXI1 forkhead box I1 0.254888
SERP1 stress-associated endoplasmic reticulum protein 1 0.252774
SOD2 superoxide dismutase 2, mitochondrial 0.252422
TSPAN1 tetraspanin 1 0.24996
SAV1 salvador family WW domain containing protein 1 0.244345
CCND1 cyclin D1 0.243645
LYZ lysozyme 0.242945
INSL3 insulin-like 3 (Leydig cell) 0.240847
NR2F6 nuclear receptor subfamily 2, group F, member 6 0.235268
CD40 CD40 molecule, TNF receptor superfamily member 5 0.235268
PMF1 polyamine-modulated factor 1 0.23353
GNPDA1 glucosamine-6-phosphate deaminase 1 0.231795
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.231448
NCAM1 neural cell adhesion molecule 1 0.227297
OPTC opticin 0.225229
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.224884
CD84 CD84 molecule 0.213621
ESR1 estrogen receptor 1 0.208579
RAB2A RAB2A, member RAS oncogene family 0.207578
IGFBP3 insulin-like growth factor binding protein 3 0.202946
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 0.201635
C7ORF49 chromosome 7 open reading frame 49 0.197099
CD226 CD226 molecule 0.193915
CD34 CD34 molecule 0.190786
AP1G1 adaptor-related protein complex 1, gamma 1 subunit 0.189551
FBN2 fibrillin 2 0.188326
MIR222 microRNA 222 0.187719
CTSB cathepsin B 0.186811
PRDX2 peroxiredoxin 2 0.18621
SLC30A2 solute carrier family 30 (zinc transporter), member 2 0.185016
SECISBP2 SECIS binding protein 2 0.18472
RNASEH2A ribonuclease H2, subunit A 0.180937
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 0.180652
MMP23B matrix metallopeptidase 23B 0.178403
RXRB retinoid X receptor, beta 0.176485
CD19 CD19 molecule 0.175411
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.172291
KRT20 keratin 20, type I 0.169812
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 0.168617
SRRM2 serine/arginine repetitive matrix 2 0.167682
TP53 tumor protein p53 0.166995
GHRH growth hormone releasing hormone 0.166544
PROK1 prokineticin 1 0.165874
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 0.165217
FGFR1 fibroblast growth factor receptor 1 0.165001
GAGE1 G antigen 1 0.164359
IFNA1 interferon, alpha 1 0.164359
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 0.164359
ERP29 endoplasmic reticulum protein 29 0.163317
GHSR growth hormone secretagogue receptor 0.163111
CAT catalase 0.160387
TRIM37 tripartite motif containing 37 0.15948
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) 0.141457
ACOX1 acyl-CoA oxidase 1, palmitoyl 0.133958
RAB3D RAB3D, member RAS oncogene family 0.133669
F7 coagulation factor VII (serum prothrombin conversion accelerator) 0.133412
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.133329
LNPEP leucyl/cystinyl aminopeptidase 0.133138
NLRP12 NLR family, pyrin domain containing 12 0.133084
SIX4 SIX homeobox 4 0.13183
PGD phosphogluconate dehydrogenase 0.131781
FRS2 fibroblast growth factor receptor substrate 2 0.131173
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 0.129724
NOTCH1 notch 1 0.129513
GAGE12I G antigen 12I 0.129129
SPAG7 sperm associated antigen 7 0.129082
MCM3 minichromosome maintenance complex component 3 0.12894
ASPH aspartate beta-hydroxylase 0.128715
PCSK2 proprotein convertase subtilisin/kexin type 2 0.128537
TRIB1 tribbles pseudokinase 1 0.128537
LGALS7B lectin, galactoside-binding, soluble, 7B 0.128086
PDGFA platelet-derived growth factor alpha polypeptide 0.127966
HAT1 histone acetyltransferase 1 0.127547
TMEM127 transmembrane protein 127 0.127351
NGDN neuroguidin, EIF4E binding protein 0.126726
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.126688
HECA headcase homolog (Drosophila) 0.126011
ACAP3 ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 0.125529
UST uronyl-2-sulfotransferase 0.125467
GP2 glycoprotein 2 (zymogen granule membrane) 0.124297
CHST14 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14 0.124163
CD3D CD3d molecule, delta (CD3-TCR complex) 0.123666
MGAM maltase-glucoamylase 0.12341
KCNAB2 potassium channel, voltage gated subfamily A regulatory beta subunit 2 0.123106
TOX thymocyte selection-associated high mobility group box 0.122817
RXRA retinoid X receptor, alpha 0.122793
CRABP1 cellular retinoic acid binding protein 1 0.122624
HES2 hes family bHLH transcription factor 2 0.122228
COL3A1 collagen, type III, alpha 1 0.121389
PRDM16 PR domain containing 16 0.121363
OSCAR osteoclast associated, immunoglobulin-like receptor 0.121098
TSPY3 testis specific protein, Y-linked 3 0.120832
TSPY10 testis specific protein, Y-linked 10 0.120832
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.120453
ANKRD11 ankyrin repeat domain 11 0.119332
IL16 interleukin 16 0.119039
PROK2 prokineticin 2 0.119039
MRAP melanocortin 2 receptor accessory protein 0.118206
CLEC4C C-type lectin domain family 4, member C 0.117963
CD276 CD276 molecule 0.117716
SDHAF2 succinate dehydrogenase complex assembly factor 2 0.117685
CCL13 chemokine (C-C motif) ligand 13 0.117372
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 0.117122
CXCL14 chemokine (C-X-C motif) ligand 14 0.117058
CFD complement factor D (adipsin) 0.116929
CHGA chromogranin A 0.116606
SERPINA6 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6 0.116149
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 0.116116
MMP11 matrix metallopeptidase 11 0.114692
CYB5A cytochrome b5 type A (microsomal) 0.114692
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.11441
UROD uroporphyrinogen decarboxylase 0.113661
HNMT histamine N-methyltransferase 0.113333
RPSA ribosomal protein SA 0.113004
VCAM1 vascular cell adhesion molecule 1 0.112743
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.112706
RASSF1 Ras association (RalGDS/AF-6) domain family member 1 0.112668
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.111448
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.110981
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 0.110423
NID1 nidogen 1 0.10994
VEGFC vascular endothelial growth factor C 0.109325
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 0.108783
CASQ2 calsequestrin 2 (cardiac muscle) 0.108614
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.108192
CD58 CD58 molecule 0.108066
PTMS parathymosin 0.107589
MCM8 minichromosome maintenance complex component 8 0.107372
CASQ1 calsequestrin 1 (fast-twitch, skeletal muscle) 0.107112
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 0.106581
OAT ornithine aminotransferase 0.106403
AMELY amelogenin, Y-linked 0.106269
IL22 interleukin 22 0.106136
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 0.105868
PHB prohibitin 0.105273
TPT1 tumor protein, translationally-controlled 1 0.105228
CLEC3A C-type lectin domain family 3, member A 0.105091
CLEC2B C-type lectin domain family 2, member B 0.104489
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.104395
LAMA2 laminin, alpha 2 0.103356
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog 0.10326
GAS6 growth arrest-specific 6 0.10302
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1 0.102492
AMELX amelogenin, X-linked 0.102393
MIR221 microRNA 221 0.102344
NDRG1 N-myc downstream regulated 1 0.10195