gossypol-3637 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the gossypol-3637 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACSL5 acyl-CoA synthetase long-chain family member 5
ANGPTL2 angiopoietin-like 2
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASCL1 achaete-scute family bHLH transcription factor 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BIN1 bridging integrator 1
BIRC3 baculoviral IAP repeat containing 3
C1ORF54 chromosome 1 open reading frame 54
CAPN2 calpain 2, (m/II) large subunit
CASP10 caspase 10, apoptosis-related cysteine peptidase
CDK13 cyclin-dependent kinase 13
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CHST5 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5
CLCN4 chloride channel, voltage-sensitive 4
CLTA clathrin, light chain A
CNTD2 cyclin N-terminal domain containing 2
CTAGE5 CTAGE family, member 5
CTBP2 C-terminal binding protein 2
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DAPK2 death-associated protein kinase 2
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DTNA dystrobrevin, alpha
DUX1 double homeobox 1
EMCN endomucin
ERCC2 excision repair cross-complementation group 2
FGF2 fibroblast growth factor 2 (basic)
FLT3 fms-related tyrosine kinase 3
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXG1 forkhead box G1
GADD45A growth arrest and DNA-damage-inducible, alpha
GTPBP1 GTP binding protein 1
GTPBP2 GTP binding protein 2
HOXA11 homeobox A11
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
ICAM1 intercellular adhesion molecule 1
IGFBP3 insulin-like growth factor binding protein 3
IL21R interleukin 21 receptor
ING2 inhibitor of growth family, member 2
INHBE inhibin, beta E
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
LAT2 linker for activation of T cells family, member 2
LBP lipopolysaccharide binding protein
LINC00597 long intergenic non-protein coding RNA 597
LLGL1 lethal giant larvae homolog 1 (Drosophila)
MARS methionyl-tRNA synthetase
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MID1IP1 MID1 interacting protein 1
MST1 macrophage stimulating 1
N4BP2L2 NEDD4 binding protein 2-like 2
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NUPR1 nuclear protein, transcriptional regulator, 1
OXCT2 3-oxoacid CoA transferase 2
P3H2 prolyl 3-hydroxylase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDE10A phosphodiesterase 10A
PDZD2 PDZ domain containing 2
PLAC1 placenta-specific 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PSPH phosphoserine phosphatase
RAD52 RAD52 homolog (S. cerevisiae)
RASIP1 Ras interacting protein 1
REPS1 RALBP1 associated Eps domain containing 1
RPL18 ribosomal protein L18
RUNDC3B RUN domain containing 3B
SAMD4A sterile alpha motif domain containing 4A
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH3BP2 SH3-domain binding protein 2
SIX3 SIX homeobox 3
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX10 SRY (sex determining region Y)-box 10
SSBP1 single-stranded DNA binding protein 1, mitochondrial
SYN2 synapsin II
TGFA transforming growth factor, alpha
TRA2A transformer 2 alpha homolog (Drosophila)
TRAPPC9 trafficking protein particle complex 9
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WDR33 WD repeat domain 33
WNT10B wingless-type MMTV integration site family, member 10B
WSB1 WD repeat and SOCS box containing 1
ZBTB17 zinc finger and BTB domain containing 17
ZSCAN12 zinc finger and SCAN domain containing 12

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AHSP alpha hemoglobin stabilizing protein
APOBEC3C apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C
ARHGAP4 Rho GTPase activating protein 4
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38
ARID3B AT rich interactive domain 3B (BRIGHT-like)
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)
BCO1 beta-carotene oxygenase 1
BMP10 bone morphogenetic protein 10
BMP4 bone morphogenetic protein 4
C1ORF21 chromosome 1 open reading frame 21
C7ORF43 chromosome 7 open reading frame 43
CGA glycoprotein hormones, alpha polypeptide
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CPNE7 copine VII
CRIP1 cysteine-rich protein 1 (intestinal)
DEPDC5 DEP domain containing 5
DGKE diacylglycerol kinase, epsilon 64kDa
DIO1 deiodinase, iodothyronine, type I
DOC2A double C2-like domains, alpha
DOK5 docking protein 5
EPN1 epsin 1
ERCC6L excision repair cross-complementation group 6-like
ERN2 endoplasmic reticulum to nucleus signaling 2
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGF23 fibroblast growth factor 23
FGL1 fibrinogen-like 1
FLJ22184
FOXF2 forkhead box F2
FRMD1 FERM domain containing 1
GATA4 GATA binding protein 4
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide
GNB1L guanine nucleotide binding protein (G protein), beta polypeptide 1-like
GPR19 G protein-coupled receptor 19
HDAC7 histone deacetylase 7
HIST1H4A histone cluster 1, H4a
HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1
HOXC5 homeobox C5
HSPA1A heat shock 70kDa protein 1A
HSPA2 heat shock 70kDa protein 2
IL22 interleukin 22
INPP5J inositol polyphosphate-5-phosphatase J
ITM2C integral membrane protein 2C
KCNIP1 Kv channel interacting protein 1
KRT15 keratin 15, type I
LHX1 LIM homeobox 1
LIF leukemia inhibitory factor
LOC390998 ribosomal protein L10 pseudogene
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
MAGEA5 melanoma antigen family A5
MAL mal, T-cell differentiation protein
MAST3 microtubule associated serine/threonine kinase 3
MRPL41 mitochondrial ribosomal protein L41
MUC3A mucin 3A, cell surface associated
MYOZ3 myozenin 3
NACA2 nascent polypeptide-associated complex alpha subunit 2
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NIPAL2 NIPA-like domain containing 2
NPTX2 neuronal pentraxin II
OLFML2A olfactomedin-like 2A
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6
PDHA2 pyruvate dehydrogenase (lipoamide) alpha 2
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1
PLEKHS1 pleckstrin homology domain containing, family S member 1
PMCH pro-melanin-concentrating hormone
POU4F2 POU class 4 homeobox 2
PPT2 palmitoyl-protein thioesterase 2
PWAR5 Prader Willi/Angelman region RNA 5
RAB40AL RAB40A, member RAS oncogene family-like
RAI2 retinoic acid induced 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RELN reelin
RIBC2 RIB43A domain with coiled-coils 2
RNF122 ring finger protein 122
RSPH14 radial spoke head 14 homolog (Chlamydomonas)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC22A18AS solute carrier family 22 (organic cation transporter), member 18 antisense
STAG3 stromal antigen 3
STARD3 StAR-related lipid transfer (START) domain containing 3
STARD8 StAR-related lipid transfer (START) domain containing 8
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TBKBP1 TBK1 binding protein 1
TBL1Y transducin (beta)-like 1, Y-linked
TCP10 t-complex 10
TFDP3 transcription factor Dp family, member 3
TGFBR3 transforming growth factor, beta receptor III
TMPRSS4 transmembrane protease, serine 4
TNFRSF14 tumor necrosis factor receptor superfamily, member 14
TRPM2 transient receptor potential cation channel, subfamily M, member 2
UBOX5 U-box domain containing 5
USP27X ubiquitin specific peptidase 27, X-linked
ZBED1 zinc finger, BED-type containing 1
ZCCHC24 zinc finger, CCHC domain containing 24
ZDHHC14 zinc finger, DHHC-type containing 14
ZFHX4 zinc finger homeobox 4
ZFP37 ZFP37 zinc finger protein