gossypol-4296 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the gossypol-4296 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ADM adrenomedullin
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL4 angiopoietin-like 4
ARC activity-regulated cytoskeleton-associated protein
ARG2 arginase 2
ARID5A AT rich interactive domain 5A (MRF1-like)
ARNT aryl hydrocarbon receptor nuclear translocator
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BIK BCL2-interacting killer (apoptosis-inducing)
BRF1 BRF1, RNA polymerase III transcription initiation factor 90 kDa subunit
C10ORF10 chromosome 10 open reading frame 10
CBS cystathionine-beta-synthase
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN18 claudin 18
CLIC4 chloride intracellular channel 4
CPEB3 cytoplasmic polyadenylation element binding protein 3
CTBP2 C-terminal binding protein 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DST dystonin
DTNA dystrobrevin, alpha
DUSP1 dual specificity phosphatase 1
DZIP1 DAZ interacting zinc finger protein 1
EGR1 early growth response 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FGL1 fibrinogen-like 1
FLT1 fms-related tyrosine kinase 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCNT4 glucosaminyl (N-acetyl) transferase 4, core 2
GK glycerol kinase
GPR22 G protein-coupled receptor 22
HIST1H1D histone cluster 1, H1d
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL2 interleukin 2
IL33R interleukin 33 receptor
IL6ST interleukin 6 signal transducer
INE1 inactivation escape 1 (non-protein coding)
IRF4 interferon regulatory factor 4
JUN jun proto-oncogene
KCNG1 potassium channel, voltage gated modifier subfamily G, member 1
KDM7A lysine (K)-specific demethylase 7A
KLF4 Kruppel-like factor 4 (gut)
MAP1B microtubule-associated protein 1B
MED18 mediator complex subunit 18
NDRG1 N-myc downstream regulated 1
NFIL3 nuclear factor, interleukin 3 regulated
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18
NUPR1 nuclear protein, transcriptional regulator, 1
PADI2 peptidyl arginine deiminase, type II
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PLIN2 perilipin 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIA peptidylprolyl isomerase A (cyclophilin A)
PRIM2 primase, DNA, polypeptide 2 (58kDa)
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
PVT1 Pvt1 oncogene (non-protein coding)
RHEB Ras homolog enriched in brain
RND1 Rho family GTPase 1
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SSTR2 somatostatin receptor 2
STC1 stanniocalcin 1
STC2 stanniocalcin 2
STOML1 stomatin (EPB72)-like 1
SUGP1 SURP and G patch domain containing 1
TBL1Y transducin (beta)-like 1, Y-linked
TBR1 T-box, brain, 1
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor)
TEX14 testis expressed 14
THBD thrombomodulin
THSD4 thrombospondin, type I, domain containing 4
TMEM74B transmembrane protein 74B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIB3 tribbles pseudokinase 3
TRIM25 tripartite motif containing 25
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
WRNIP1 Werner helicase interacting protein 1
WSB1 WD repeat and SOCS box containing 1
WTAP Wilms tumor 1 associated protein
ZFX zinc finger protein, X-linked
ZNF235 zinc finger protein 235
ZNF609 zinc finger protein 609
ZNF771 zinc finger protein 771
ZSCAN32 zinc finger and SCAN domain containing 32

decreased expression

Symbol Name
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7
ACBD4 acyl-CoA binding domain containing 4
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ARHGEF16 Rho guanine nucleotide exchange factor (GEF) 16
ARHGEF26 Rho guanine nucleotide exchange factor (GEF) 26
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BHLHB9 basic helix-loop-helix domain containing, class B, 9
BTBD2 BTB (POZ) domain containing 2
CASKIN2 CASK interacting protein 2
CBX8 chromobox homolog 8
CCDC106 coiled-coil domain containing 106
CCNE1 cyclin E1
CD82 CD82 molecule
CENPT centromere protein T
CHRNA9 cholinergic receptor, nicotinic, alpha 9 (neuronal)
CHST10 carbohydrate sulfotransferase 10
CISH cytokine inducible SH2-containing protein
CLIP2 CAP-GLY domain containing linker protein 2
CORO1A coronin, actin binding protein, 1A
CRMP1 collapsin response mediator protein 1
CRY2 cryptochrome circadian clock 2
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DUSP9 dual specificity phosphatase 9
EFNB1 ephrin-B1
EN1 engrailed homeobox 1
EN2 engrailed homeobox 2
EPN3 epsin 3
ERN2 endoplasmic reticulum to nucleus signaling 2
EVPL envoplakin
FAM53C family with sequence similarity 53, member C
FBXL7 F-box and leucine-rich repeat protein 7
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GLDC glycine dehydrogenase (decarboxylating)
GLS2 glutaminase 2 (liver, mitochondrial)
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GRM6 glutamate receptor, metabotropic 6
H1F0 H1 histone family, member 0
HOXC13 homeobox C13
IFNA17 interferon, alpha 17
IGSF3 immunoglobulin superfamily, member 3
INHBB inhibin, beta B
IQCC IQ motif containing C
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDM5C lysine (K)-specific demethylase 5C
KIAA0319L KIAA0319-like
KIAA1462 KIAA1462
KLHL25 kelch-like family member 25
KLHL36 kelch-like family member 36
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LRRC61 leucine rich repeat containing 61
LRRK1 leucine-rich repeat kinase 1
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1
MINOS1P1 mitochondrial inner membrane organizing system 1 pseudogene 1
MXD3 MAX dimerization protein 3
NARFL nuclear prelamin A recognition factor-like
NID2 nidogen 2 (osteonidogen)
NPY1R neuropeptide Y receptor Y1
OSR2 odd-skipped related transciption factor 2
PAIP2B poly(A) binding protein interacting protein 2B
PC pyruvate carboxylase
PGP phosphoglycolate phosphatase
PLEKHF1 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLXNB3 plexin B3
POLL polymerase (DNA directed), lambda
PRB3 proline-rich protein BstNI subfamily 3
PRR15L proline rich 15-like
PRR4 proline rich 4 (lacrimal)
RHOBTB2 Rho-related BTB domain containing 2
ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)
RPL10L ribosomal protein L10-like
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SHPK sedoheptulokinase
SIRT6 sirtuin 6
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC4A8 solute carrier family 4, sodium bicarbonate cotransporter, member 8
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOX21 SRY (sex determining region Y)-box 21
SP140L SP140 nuclear body protein-like
TBXAS1 thromboxane A synthase 1 (platelet)
TCEAL2 transcription elongation factor A (SII)-like 2
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNRC6B trinucleotide repeat containing 6B
TNS2 tensin 2
USB1 U6 snRNA biogenesis 1
VANGL1 VANGL planar cell polarity protein 1
WDR62 WD repeat domain 62
WNT10B wingless-type MMTV integration site family, member 10B
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
ZBTB22 zinc finger and BTB domain containing 22
ZMYM3 zinc finger, MYM-type 3
ZNF222 zinc finger protein 222
ZNF426 zinc finger protein 426
ZNF639 zinc finger protein 639