gout Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi. (Experimental Factor Ontology, EFO_0004274)
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Genes

71 genes associated with the disease gout in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 3.31608
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 2.75019
PDZK1 PDZ domain containing 1 1.74367
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 1.723
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 1.61356
INHBC inhibin, beta C 1.58223
KRTCAP2 keratinocyte associated protein 2 1.30085
TRIM46 tripartite motif containing 46 1.30085
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 1.22898
HNF4G hepatocyte nuclear factor 4, gamma 1.21385
HLF hepatic leukemia factor 1.20753
A1CF APOBEC1 complementation factor 1.19506
SFMBT1 Scm-like with four mbt domains 1 1.13588
VEGFA vascular endothelial growth factor A 1.10381
IGF1R insulin-like growth factor 1 receptor 1.04495
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 0.995303
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2 0.932337
OVOL1 ovo-like zinc finger 1 0.932337
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.894262
ATXN2 ataxin 2 0.830123
R3HDM2 R3H domain containing 2 0.790827
NRXN2 neurexin 2 0.7623
TMEM171 transmembrane protein 171 0.7623
SF1 splicing factor 1 0.745324
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.641775
SGK1 serum/glucocorticoid regulated kinase 1 0.63207
GCKR glucokinase (hexokinase 4) regulator 0.63207
RREB1 ras responsive element binding protein 1 0.63207
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 0.602429
ZNF518B zinc finger protein 518B 0.58494
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.572184
LRRC16A leucine rich repeat containing 16A 0.5306
SLC16A9 solute carrier family 16, member 9 0.52461
BCAS3 breast carcinoma amplified sequence 3 0.52461
STC1 stanniocalcin 1 0.52461
ORC4 origin recognition complex, subunit 4 0.486425
MLXIP MLX interacting protein 0.464771
HNF1A HNF1 homeobox A 0.414708
PYGM phosphorylase, glycogen, muscle 0.408752
CERS2 ceramide synthase 2 0.403461
INSR insulin receptor 0.403461
ADPGK ADP-dependent glucokinase 0.368757
QRICH2 glutamine rich 2 0.368757
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.327313
FRK fyn-related Src family tyrosine kinase 0.285417
CLDN24 claudin 24 0.285417
FGF5 fibroblast growth factor 5 0.285417
FGFR2 fibroblast growth factor receptor 2 0.264872
OR13C8 olfactory receptor, family 13, subfamily C, member 8 0.256228
CRIP3 cysteine-rich protein 3 0.256228
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 0.256228
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.256228
USP2 ubiquitin specific peptidase 2 0.197766
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2 0.197766
SMIM21 small integral membrane protein 21 0.197766
MC4R melanocortin 4 receptor 0.197766
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.15771
SHF Src homology 2 domain containing F 0.15771
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.15771
ARID1B AT rich interactive domain 1B (SWI1-like) 0.15771
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.126165
KCNMB2 potassium channel subfamily M regulatory beta subunit 2 0.126165
LACC1 laccase (multicopper oxidoreductase) domain containing 1 0.126165
MYO18B myosin XVIIIB 0.126165
VSTM4 V-set and transmembrane domain containing 4 0.100789
TENM2 teneurin transmembrane protein 2 0.100789
METTL6 methyltransferase like 6 0.100789
WDR1 WD repeat domain 1 0.100789
SLC48A1 solute carrier family 48 (heme transporter), member 1 0.080593
ARHGAP26 Rho GTPase activating protein 26 0.052255
DACH1 dachshund family transcription factor 1 0.043246