gout Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi. (Experimental Factor Ontology, EFO_0004274)
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Genes

200 genes co-occuring with the disease gout in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
BCKDHA branched chain keto acid dehydrogenase E1, alpha polypeptide 3.23329
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 2.46059
HPRT1 hypoxanthine phosphoribosyltransferase 1 2.24311
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 2.1222
UMOD uromodulin 2.00378
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 1.78038
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.68544
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 1.67864
PRPS1L1 phosphoribosyl pyrophosphate synthetase 1-like 1 1.67503
NLRP3 NLR family, pyrin domain containing 3 1.66961
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 1.62425
PRPS1 phosphoribosyl pyrophosphate synthetase 1 1.60591
APRT adenine phosphoribosyltransferase 1.48472
LRRC16A leucine rich repeat containing 16A 1.47813
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 1.46056
SLC16A9 solute carrier family 16, member 9 1.41052
IL1RN interleukin 1 receptor antagonist 1.40614
CARD17 caspase recruitment domain family, member 17 1.4022
XDH xanthine dehydrogenase 1.27344
PRPS2 phosphoribosyl pyrophosphate synthetase 2 1.26952
ALDH16A1 aldehyde dehydrogenase 16 family, member A1 1.24993
IL1B interleukin 1, beta 1.21045
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.13416
ALPK1 alpha-kinase 1 1.11898
TMEM171 transmembrane protein 171 1.09461
CRP C-reactive protein, pentraxin-related 1.06354
PRPSAP1 phosphoribosyl pyrophosphate synthetase-associated protein 1 1.0585
POMC proopiomelanocortin 1.00879
SIK1 salt-inducible kinase 1 0.993596
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 0.9696
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 0.96918
PDZK1 PDZ domain containing 1 0.946186
OR2M3 olfactory receptor, family 2, subfamily M, member 3 0.919261
GDA guanine deaminase 0.902389
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5 0.888029
MC3R melanocortin 3 receptor 0.872462
R3HDM2 R3H domain containing 2 0.848307
HNF1B HNF1 homeobox B 0.839296
SP9 Sp9 transcription factor 0.837246
SPTA1 spectrin, alpha, erythrocytic 1 0.830279
MEFV Mediterranean fever 0.829049
TAS2R30 taste receptor, type 2, member 30 0.821257
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.815514
LRRC3 leucine rich repeat containing 3 0.808949
SLC22A8 solute carrier family 22 (organic anion transporter), member 8 0.808949
TREM1 triggering receptor expressed on myeloid cells 1 0.806488
MOCOS molybdenum cofactor sulfurase 0.805257
PRTFDC1 phosphoribosyl transferase domain containing 1 0.774114
ECD ecdysoneless homolog (Drosophila) 0.772887
ALB albumin 0.760639
TNF tumor necrosis factor 0.752492
G6PC glucose-6-phosphatase, catalytic subunit 0.742329
TAS2R16 taste receptor, type 2, member 16 0.730976
PNP purine nucleoside phosphorylase 0.722077
CXCL8 chemokine (C-X-C motif) ligand 8 0.681495
SYTL5 synaptotagmin-like 5 0.679499
SYK spleen tyrosine kinase 0.676706
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 0.676308
MYD88 myeloid differentiation primary response 88 0.671925
TLR2 toll-like receptor 2 0.669538
IRG1 immunoresponsive 1 homolog (mouse) 0.655254
F12 coagulation factor XII (Hageman factor) 0.653671
INS insulin 0.652484
HNF4G hepatocyte nuclear factor 4, gamma 0.652089
PPAT phosphoribosyl pyrophosphate amidotransferase 0.650113
TLR4 toll-like receptor 4 0.645375
NLRP1 NLR family, pyrin domain containing 1 0.626495
AIM2 absent in melanoma 2 0.612011
FLT3LG fms-related tyrosine kinase 3 ligand 0.586276
LGALS9 lectin, galactoside-binding, soluble, 9 0.573439
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2 0.563723
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 0.552851
INHBC inhibin, beta C 0.545481
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 0.545093
ADSS adenylosuccinate synthase 0.538506
LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3 0.538506
CARD8 caspase recruitment domain family, member 8 0.531154
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 0.527676
NPHP1 nephronophthisis 1 (juvenile) 0.52729
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 0.526132
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 0.519961
ACE angiotensin I converting enzyme 0.517649
GUSB glucuronidase, beta 0.517649
NLRC4 NLR family, CARD domain containing 4 0.512264
APOB apolipoprotein B 0.511496
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein 0.497321
PYCARD PYD and CARD domain containing 0.494648
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 0.493503
PRKG2 protein kinase, cGMP-dependent, type II 0.484744
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.475634
TMX1 thioredoxin-related transmembrane protein 1 0.472982
NPHP4 nephronophthisis 4 0.471846
PYDC1 PYD (pyrin domain) containing 1 0.465416
B2M beta-2-microglobulin 0.459751
TRIM46 tripartite motif containing 46 0.449947
S100A9 S100 calcium binding protein A9 0.448064
ANKH ANKH inorganic pyrophosphate transport regulator 0.442042
S100A8 S100 calcium binding protein A8 0.440538
PANX1 pannexin 1 0.42814
SP6 Sp6 transcription factor 0.425139
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 0.424765
SFMBT1 Scm-like with four mbt domains 1 0.42139
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.419517
ADSL adenylosuccinate lyase 0.417644
CALCB calcitonin-related polypeptide beta 0.410909
INHBB inhibin, beta B 0.407172
SYT7 synaptotagmin VII 0.401945
A1CF APOBEC1 complementation factor 0.401572
TMOD4 tropomodulin 4 (muscle) 0.401199
PLAA phospholipase A2-activating protein 0.39598
AMPD1 adenosine monophosphate deaminase 1 0.386308
AMPD2 adenosine monophosphate deaminase 2 0.382223
AMPD3 adenosine monophosphate deaminase 3 0.380368
NOD2 nucleotide-binding oligomerization domain containing 2 0.377402
CRYM crystallin, mu 0.370737
IL6 interleukin 6 0.368518
IARS isoleucyl-tRNA synthetase 0.364085
SYT2 synaptotagmin II 0.363347
KIR2DL4 killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 0.362609
GADD45B growth arrest and DNA-damage-inducible, beta 0.362239
CAT catalase 0.351555
CLEC12A C-type lectin domain family 12, member A 0.347879
LECT2 leukocyte cell-derived chemotaxin 2 0.343106
SELE selectin E 0.342006
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.341639
TRPV1 transient receptor potential cation channel, subfamily V, member 1 0.3292
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.328469
GSR glutathione reductase 0.327375
NT5E 5'-nucleotidase, ecto (CD73) 0.324823
TAS2R38 taste receptor, type 2, member 38 0.324094
ILVBL ilvB (bacterial acetolactate synthase)-like 0.320817
APOA1 apolipoprotein A-I 0.317545
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.317545
FBXL20 F-box and leucine-rich repeat protein 20 0.303059
SLC2A12 solute carrier family 2 (facilitated glucose transporter), member 12 0.298731
CTSB cathepsin B 0.298371
GZMK granzyme K (granzyme 3; tryptase II) 0.297291
LPA lipoprotein, Lp(a) 0.295492
CST3 cystatin C 0.293334
IRAK1 interleukin-1 receptor-associated kinase 1 0.291539
NLRP2 NLR family, pyrin domain containing 2 0.290462
CCL2 chemokine (C-C motif) ligand 2 0.280082
ADK adenosine kinase 0.277584
PFKM phosphofructokinase, muscle 0.275445
TRPM3 transient receptor potential cation channel, subfamily M, member 3 0.272953
NT5C 5', 3'-nucleotidase, cytosolic 0.271174
CXCL16 chemokine (C-X-C motif) ligand 16 0.268332
MMP3 matrix metallopeptidase 3 0.250311
NARS asparaginyl-tRNA synthetase 0.24715
BAG6 BCL2-associated athanogene 6 0.245046
CD70 CD70 molecule 0.244696
RREB1 ras responsive element binding protein 1 0.243645
SPAG7 sperm associated antigen 7 0.242595
HLA-B major histocompatibility complex, class I, B 0.23945
HP haptoglobin 0.23945
PTH parathyroid hormone 0.239101
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 0.23492
HPR haptoglobin-related protein 0.233878
FFAR4 free fatty acid receptor 4 0.230755
TOLLIP toll interacting protein 0.230409
MSH5 mutS homolog 5 0.227988
LCAT lecithin-cholesterol acyltransferase 0.225573
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 0.222479
TIMELESS timeless circadian clock 0.218374
CELA2A chymotrypsin-like elastase family, member 2A 0.217012
NPB neuropeptide B 0.216332
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.211261
UBTF upstream binding transcription factor, RNA polymerase I 0.208245
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.204923
PPA1 pyrophosphatase (inorganic) 1 0.201635
TOP3A topoisomerase (DNA) III alpha 0.200006
SLCO1C1 solute carrier organic anion transporter family, member 1C1 0.194548
KIF3A kinesin family member 3A 0.191408
IGLV5-52 immunoglobulin lambda variable 5-52 0.186811
TLR1 toll-like receptor 1 0.18651
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 0.185313
MMP2 matrix metallopeptidase 2 0.18472
TRIB1 tribbles pseudokinase 1 0.182666
OR10T2 olfactory receptor, family 10, subfamily T, member 2 0.180937
CD79A CD79a molecule, immunoglobulin-associated alpha 0.180652
LPL lipoprotein lipase 0.179802
ACVR1B activin A receptor, type IB 0.178403
CASP5 caspase 5, apoptosis-related cysteine peptidase 0.178126
REN renin 0.177029
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.176757
CCL3 chemokine (C-C motif) ligand 3 0.176485
LGALS13 lectin, galactoside-binding, soluble, 13 0.176215
LRP2 low density lipoprotein receptor-related protein 2 0.175146
LY96 lymphocyte antigen 96 0.172291
TRDN triadin 0.171785
CD209 CD209 molecule 0.168854
PYGB phosphorylase, glycogen; brain 0.166995
TRPV2 transient receptor potential cation channel, subfamily V, member 2 0.166995
PYGL phosphorylase, glycogen, liver 0.165001
F11 coagulation factor XI 0.165001
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.164786
ADA adenosine deaminase 0.164149
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 0.159302
LEP leptin 0.158266
HRAS Harvey rat sarcoma viral oncogene homolog 0.158097