gout Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi. (Experimental Factor Ontology, EFO_0004274)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:13189
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Genes

139 genes associated with the disease gout in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9 4.56214
WDR1 WD repeat domain 1 3.66893
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 3.23175
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 2.78112
CLNK cytokine-dependent hematopoietic cell linker 2.73745
PKD2 polycystic kidney disease 2 (autosomal dominant) 2.73113
LRRC16A leucine rich repeat containing 16A 2.66651
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 2.64205
ZNF518B zinc finger protein 518B 2.61015
SLC17A4 solute carrier family 17, member 4 2.54204
GCKR glucokinase (hexokinase 4) regulator 2.49428
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 2.39006
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 2.26501
SLC17A2 solute carrier family 17, member 2 2.24059
SLC16A9 solute carrier family 16, member 9 2.23172
SCGN secretagogin, EF-hand calcium binding protein 2.22117
INHBC inhibin, beta C 2.15645
NRXN2 neurexin 2 2.13078
PDZK1 PDZ domain containing 1 2.0495
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa 2.04324
R3HDM2 R3H domain containing 2 2.03322
TRIM38 tripartite motif containing 38 1.99794
IFT172 intraflagellar transport 172 1.99149
TRIM46 tripartite motif containing 46 1.96585
RREB1 ras responsive element binding protein 1 1.96579
HIST1H1C histone cluster 1, H1c 1.94187
MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2 1.90896
HNF4G hepatocyte nuclear factor 4, gamma 1.89896
HLF hepatic leukemia factor 1.89531
HIST1H2AB histone cluster 1, H2ab 1.89284
A1CF APOBEC1 complementation factor 1.88858
HFE hemochromatosis 1.87927
HIST1H3B histone cluster 1, H3b 1.87629
MEPE matrix extracellular phosphoglycoprotein 1.86835
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 1.85203
ZNF513 zinc finger protein 513 1.84807
FNDC4 fibronectin type III domain containing 4 1.84759
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G 1.84556
SFMBT1 Scm-like with four mbt domains 1 1.84278
SPP1 secreted phosphoprotein 1 1.82995
SNX17 sorting nexin 17 1.82636
NRBP1 nuclear receptor binding protein 1 1.82398
HIST1H4C histone cluster 1, H4c 1.80562
IGF1R insulin-like growth factor 1 receptor 1.80297
HIST1H2BA histone cluster 1, H2ba 1.79965
HIST1H1T histone cluster 1, H1t 1.7736
OVOL1 ovo-like zinc finger 1 1.75175
UBE2Q2 ubiquitin-conjugating enzyme E2Q family member 2 1.71806
ZNF512 zinc finger protein 512 1.70675
C2ORF16 chromosome 2 open reading frame 16 1.70555
BAZ1B bromodomain adjacent to zinc finger domain, 1B 1.69467
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 1.68619
AGBL4 ATP/GTP binding protein-like 4 1.65618
ATXN2 ataxin 2 1.64762
GPN1 GPN-loop GTPase 1 1.64138
HIST1H4B histone cluster 1, H4b 1.62867
RELN reelin 1.61053
ASIC2 acid sensing (proton gated) ion channel 2 1.60365
TBL2 transducin (beta)-like 2 1.60045
CNTLN centlein, centrosomal protein 1.59845
MLXIPL MLX interacting protein-like 1.59578
SF1 splicing factor 1 1.59102
KAT5 K(lysine) acetyltransferase 5 1.57307
TLL1 tolloid-like 1 1.56686
CD160 CD160 molecule 1.56031
SH2B3 SH2B adaptor protein 3 1.54954
HIST1H2AA histone cluster 1, H2aa 1.53232
NRG4 neuregulin 4 1.5276
PYGM phosphorylase, glycogen, muscle 1.52025
MPV17 MpV17 mitochondrial inner membrane protein 1.51189
BCL7B B-cell CLL/lymphoma 7B 1.50809
TRIM54 tripartite motif containing 54 1.50298
BRE brain and reproductive organ-expressed (TNFRSF1A modulator) 1.47566
MUC1 mucin 1, cell surface associated 1.46358
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 1.46277
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 1.42733
BCAS3 breast carcinoma amplified sequence 3 1.42467
ORC4 origin recognition complex, subunit 4 1.41162
RNF115 ring finger protein 115 1.41101
POLR3C polymerase (RNA) III (DNA directed) polypeptide C (62kD) 1.39663
ACVR2A activin A receptor, type IIA 1.38395
NXPH4 neurexophilin 4 1.38169
GBAP1 glucosidase, beta, acid pseudogene 1 1.38007
MBD5 methyl-CpG binding domain protein 5 1.37988
RPL13A ribosomal protein L13a 1.37871
AP5B1 adaptor-related protein complex 5, beta 1 subunit 1.37484
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 1.37466
FLRT1 fibronectin leucine rich transmembrane protein 1 1.37176
NUDT17 nudix (nucleoside diphosphate linked moiety X)-type motif 17 1.36753
MAML2 mastermind-like 2 (Drosophila) 1.35275
HNF1A HNF1 homeobox A 1.32598
INSR insulin receptor 1.31635
QRICH2 glutamine rich 2 1.28906
MUC22 mucin 22 1.23079
FRK fyn-related Src family tyrosine kinase 1.21996
FGFR2 fibroblast growth factor receptor 2 1.20161
ZSCAN31 zinc finger and SCAN domain containing 31 1.19762
SLC22A7 solute carrier family 22 (organic anion transporter), member 7 1.19386
TSHR thyroid stimulating hormone receptor 1.17343
VSTM4 V-set and transmembrane domain containing 4 1.15602
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 1.15334
USP2 ubiquitin specific peptidase 2 1.14463
ARID1B AT rich interactive domain 1B (SWI1-like) 1.14381
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 1.11453
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 1.10764
F5 coagulation factor V (proaccelerin, labile factor) 1.10764
KLHL5 kelch-like family member 5 1.10555
HBG2 hemoglobin, gamma G 1.10487
CCDC102B coiled-coil domain containing 102B 1.09895
C9ORF3 chromosome 9 open reading frame 3 1.09254
MYO18B myosin XVIIIB 1.07599
DCDC2 doublecortin domain containing 2 1.06059
C1QTNF2 C1q and tumor necrosis factor related protein 2 1.04898
TENM2 teneurin transmembrane protein 2 1.04846
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D 1.03243
SLC48A1 solute carrier family 48 (heme transporter), member 1 1.02476
FRAS1 Fraser extracellular matrix complex subunit 1 1.02476
NR5A2 nuclear receptor subfamily 5, group A, member 2 1.01024
LOC728755 uncharacterized LOC728755 1.00672
TRAF3IP2 TRAF3 interacting protein 2 1.00501
CALN1 calneuron 1 1.00407
ERC2 ELKS/RAB6-interacting/CAST family member 2 1.00166
CES5A carboxylesterase 5A 0.990911
ARHGAP26 Rho GTPase activating protein 26 0.986376
SMIM23 small integral membrane protein 23 0.984263
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 0.976083
DACH1 dachshund family transcription factor 1 0.971169
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.96839
RASGRP2 RAS guanyl releasing protein 2 (calcium and DAG-regulated) 0.96005
ZNF385B zinc finger protein 385B 0.952622
GAB1 GRB2-associated binding protein 1 0.931899
RERG RAS-like, estrogen-regulated, growth inhibitor 0.929316
PTPRM protein tyrosine phosphatase, receptor type, M 0.928472
MXD3 MAX dimerization protein 3 0.925175
GRIK2 glutamate receptor, ionotropic, kainate 2 0.845646
HNF4A hepatocyte nuclear factor 4, alpha 0.766993
RNH1 ribonuclease/angiogenin inhibitor 1 0.671336
USP3 ubiquitin specific peptidase 3 0.599097
PRKCZ protein kinase C, zeta 0.554925