| Dataset | GeneRIF Biological Term Annotations |
| Category | structural or functional annotations |
| Type | biological term |
| Description | glucose-6-phosphate isomerase|This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phophsate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] (NCBI Entrez Gene Database, 2821) |
| Similar Terms | |
| Downloads & Tools |
31 genes co-occuring with the biological term gpi in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
| Symbol | Name |
|---|---|
| ADIPOQ | adiponectin, C1Q and collagen domain containing |
| AKT1 | v-akt murine thymoma viral oncogene homolog 1 |
| ALPL | alkaline phosphatase, liver/bone/kidney |
| APOH | apolipoprotein H (beta-2-glycoprotein I) |
| BST2 | bone marrow stromal cell antigen 2 |
| CD40 | CD40 molecule, TNF receptor superfamily member 5 |
| CD52 | CD52 molecule |
| F2 | coagulation factor II (thrombin) |
| G6PD | glucose-6-phosphate dehydrogenase |
| GPAA1 | glycosylphosphatidylinositol anchor attachment 1 |
| GPC3 | glypican 3 |
| GPI | glucose-6-phosphate isomerase |
| KLRK1 | killer cell lectin-like receptor subfamily K, member 1 |
| M6PR | mannose-6-phosphate receptor (cation dependent) |
| MAPK1 | mitogen-activated protein kinase 1 |
| MAPK3 | mitogen-activated protein kinase 3 |
| MDGA1 | MAM domain containing glycosylphosphatidylinositol anchor 1 |
| MICA | MHC class I polypeptide-related sequence A |
| NODAL | nodal growth differentiation factor |
| PGAP1 | post-GPI attachment to proteins 1 |
| PIGM | phosphatidylinositol glycan anchor biosynthesis, class M |
| PIGU | phosphatidylinositol glycan anchor biosynthesis, class U |
| PIGV | phosphatidylinositol glycan anchor biosynthesis, class V |
| PRNP | prion protein |
| TDGF1 | teratocarcinoma-derived growth factor 1 |
| TFF1 | trefoil factor 1 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) |
| ULBP2 | UL16 binding protein 2 |
| UMOD | uromodulin |
| VWF | von Willebrand factor |
| WNT3A | wingless-type MMTV integration site family, member 3A |
