granulomatosis Gene Set

Dataset GWASdb SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description Formation of multiple granulomas, i.e., localized nodular foci inflammation. (Human Phenotype Ontology, HP_0002955)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/HP:0002955
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Genes

196 genes associated with the granulomatosis phenotype in GWAS datasets from the GWASdb SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
LACC1 laccase (multicopper oxidoreductase) domain containing 1 2.59412
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 2.56618
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.37633
CCDC122 coiled-coil domain containing 122 2.24352
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.01405
RIPK2 receptor-interacting serine-threonine kinase 2 1.81736
FILIP1 filamin A interacting protein 1 1.77085
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.56996
HLA-B major histocompatibility complex, class I, B 1.35197
HLA-C major histocompatibility complex, class I, C 1.13911
HLA-DRA major histocompatibility complex, class II, DR alpha 1.13355
HLA-DOB major histocompatibility complex, class II, DO beta 1.12299
PSORS1C1 psoriasis susceptibility 1 candidate 1 1.11616
IL10 interleukin 10 1.01551
MATN4 matrilin 4 1.0022
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 0.98538
ALS2CL ALS2 C-terminal like 0.983355
SEPHS1 selenophosphate synthetase 1 0.962153
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 0.928083
DHDDS dehydrodolichyl diphosphate synthase 0.920767
SH3GL2 SH3-domain GRB2-like 2 0.917141
C6ORF15 chromosome 6 open reading frame 15 0.901369
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 0.882984
UPP2 uridine phosphorylase 2 0.881236
CDC42BPG CDC42 binding protein kinase gamma (DMPK-like) 0.872268
VARS2 valyl-tRNA synthetase 2, mitochondrial 0.858124
IL23R interleukin 23 receptor 0.857755
ANXA11 annexin A11 0.844276
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.838165
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 0.781779
CCHCR1 coiled-coil alpha-helical rod protein 1 0.678524
NOD2 nucleotide-binding oligomerization domain containing 2 0.648884
MICA MHC class I polypeptide-related sequence A 0.600504
C6ORF10 chromosome 6 open reading frame 10 0.514524
MOG myelin oligodendrocyte glycoprotein 0.501014
BTNL2 butyrophilin-like 2 0.49666
ERAP1 endoplasmic reticulum aminopeptidase 1 0.486444
ZNRD1-AS1 ZNRD1 antisense RNA 1 0.447241
HCP5 HLA complex P5 (non-protein coding) 0.446423
RSPO4 R-spondin 4 0.44303
STAT4 signal transducer and activator of transcription 4 0.424122
KLRC4 killer cell lectin-like receptor subfamily C, member 4 0.424122
ASTN2 astrotactin 2 0.412305
PSORS1C2 psoriasis susceptibility 1 candidate 2 0.412114
TFCP2L1 transcription factor CP2-like 1 0.410522
CSMD1 CUB and Sushi multiple domains 1 0.406111
HLA-F-AS1 HLA-F antisense RNA 1 0.406089
MICB MHC class I polypeptide-related sequence B 0.400887
DDR1 discoidin domain receptor tyrosine kinase 1 0.391344
DPCR1 diffuse panbronchiolitis critical region 1 0.389779
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.386005
ISPD isoprenoid synthase domain containing 0.384544
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.380725
PLAC9 placenta-specific 9 0.375541
LTA lymphotoxin alpha 0.372041
HCG18 HLA complex group 18 (non-protein coding) 0.3714
RNF175 ring finger protein 175 0.368942
TRIM26 tripartite motif containing 26 0.36829
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 0.368159
GRIK4 glutamate receptor, ionotropic, kainate 4 0.364547
AHCY adenosylhomocysteinase 0.364155
FOXP1 forkhead box P1 0.363471
CLASP2 cytoplasmic linker associated protein 2 0.363252
MCPH1 microcephalin 1 0.362515
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 0.361587
ATP6V1G2-DDX39B ATP6V1G2-DDX39B readthrough (NMD candidate) 0.360986
CCDC180 coiled-coil domain containing 180 0.360612
GPA33 glycoprotein A33 (transmembrane) 0.360367
C9ORF171 chromosome 9 open reading frame 171 0.359814
CNTN4 contactin 4 0.359383
HLA-F major histocompatibility complex, class I, F 0.358862
SFTA2 surfactant associated 2 0.358766
PTAR1 protein prenyltransferase alpha subunit repeat containing 1 0.358683
KDM4C lysine (K)-specific demethylase 4C 0.357797
PPTC7 PTC7 protein phosphatase homolog (S. cerevisiae) 0.35767
GPM6A glycoprotein M6A 0.355233
POU5F1 POU class 5 homeobox 1 0.354879
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.354538
KLRK1 killer cell lectin-like receptor subfamily K, member 1 0.354372
HCG27 HLA complex group 27 (non-protein coding) 0.352993
FBXL2 F-box and leucine-rich repeat protein 2 0.35237
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.352172
MUC22 mucin 22 0.351849
RPTOR regulatory associated protein of MTOR, complex 1 0.351599
DOCK4 dedicator of cytokinesis 4 0.350658
AGBL1 ATP/GTP binding protein-like 1 0.350071
WWC1 WW and C2 domain containing 1 0.349453
UBP1 upstream binding protein 1 (LBP-1a) 0.348565
PHACTR2 phosphatase and actin regulator 2 0.348565
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.348515
GPR75-ASB3 GPR75-ASB3 readthrough 0.348465
SCHIP1 schwannomin interacting protein 1 0.348416
SHANK1 SH3 and multiple ankyrin repeat domains 1 0.348076
MCF2L2 MCF.2 cell line derived transforming sequence-like 2 0.347933
DCC DCC netrin 1 receptor 0.347338
DISP2 dispatched homolog 2 (Drosophila) 0.347294
ZC3H13 zinc finger CCCH-type containing 13 0.346649
CDK19 cyclin-dependent kinase 19 0.346608
WDFY4 WDFY family member 4 0.345926
TMEM35 transmembrane protein 35 0.345695
LOC647323 uncharacterized LOC647323 0.345033
UROC1 urocanate hydratase 1 0.344857
LDB2 LIM domain binding 2 0.344245
CNOT2 CCR4-NOT transcription complex, subunit 2 0.344179
EFCAB11 EF-hand calcium binding domain 11 0.34321
AVEN apoptosis, caspase activation inhibitor 0.34312
PPP1R10 protein phosphatase 1, regulatory subunit 10 0.342968
MDC1 mediator of DNA-damage checkpoint 1 0.342936
KIF26B kinesin family member 26B 0.342466
JARID2 jumonji, AT rich interactive domain 2 0.341956
ASIC2 acid sensing (proton gated) ion channel 2 0.341868
PCDH7 protocadherin 7 0.341781
TBC1D22A TBC1 domain family, member 22A 0.341752
LUZP2 leucine zipper protein 2 0.341108
ERLEC1 endoplasmic reticulum lectin 1 0.34084
RYR2 ryanodine receptor 2 (cardiac) 0.340787
IL1R2 interleukin 1 receptor, type II 0.340707
PDZRN4 PDZ domain containing ring finger 4 0.340629
SDK2 sidekick cell adhesion molecule 2 0.340603
MS4A15 membrane-spanning 4-domains, subfamily A, member 15 0.340219
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 0.340169
WWTR1 WW domain containing transcription regulator 1 0.34002
CACNG4 calcium channel, voltage-dependent, gamma subunit 4 0.339704
KTN1 kinectin 1 (kinesin receptor) 0.339513
POU6F2 POU class 6 homeobox 2 0.339142
PCSK6 proprotein convertase subtilisin/kexin type 6 0.339006
LOC339298 uncharacterized LOC339298 0.338413
NUTM1 NUT midline carcinoma, family member 1 0.338328
CCDC42 coiled-coil domain containing 42 0.338159
ASB3 ankyrin repeat and SOCS box containing 3 0.338034
CDCP1 CUB domain containing protein 1 0.337973
PENK proenkephalin 0.337729
FAM169B family with sequence similarity 169, member B 0.337628
LPP LIM domain containing preferred translocation partner in lipoma 0.337353
PRNT prion protein (testis specific) 0.336331
IKZF5 IKAROS family zinc finger 5 (Pegasus) 0.335982
LOC100287329 uncharacterized LOC100287329 0.335965
DAAM1 dishevelled associated activator of morphogenesis 1 0.335828
ALDH9A1 aldehyde dehydrogenase 9 family, member A1 0.33538
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 0.334661
ACSBG1 acyl-CoA synthetase bubblegum family member 1 0.334338
FXYD5 FXYD domain containing ion transport regulator 5 0.33427
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.334171
FYCO1 FYVE and coiled-coil domain containing 1 0.333683
ILDR1 immunoglobulin-like domain containing receptor 1 0.333353
KANK1 KN motif and ankyrin repeat domains 1 0.333061
CDHR3 cadherin-related family member 3 0.333046
ZBTB7C zinc finger and BTB domain containing 7C 0.332971
NPHP4 nephronophthisis 4 0.332941
AGTR1 angiotensin II receptor, type 1 0.332455
CDSN corneodesmosin 0.332226
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa 0.332198
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.332141
PDZD2 PDZ domain containing 2 0.331591
ARMC9 armadillo repeat containing 9 0.331391
MYL2 myosin, light chain 2, regulatory, cardiac, slow 0.331338
TMPRSS4 transmembrane protease, serine 4 0.331207
MYO1D myosin ID 0.331129
TCF19 transcription factor 19 0.33109
FRMD4A FERM domain containing 4A 0.330885
CPVL carboxypeptidase, vitellogenic-like 0.330872
STIM1 stromal interaction molecule 1 0.330374
L3HYPDH L-3-hydroxyproline dehydratase (trans-) 0.330133
GLIS3 GLIS family zinc finger 3 0.329435
SGK223 homolog of rat pragma of Rnd2 0.327456
LINGO2 leucine rich repeat and Ig domain containing 2 0.326892
NNT nicotinamide nucleotide transhydrogenase 0.326353
CALN1 calneuron 1 0.322521
STK32B serine/threonine kinase 32B 0.320236
PTPRM protein tyrosine phosphatase, receptor type, M 0.31881
ZNF385D zinc finger protein 385D 0.31881
BSN bassoon presynaptic cytomatrix protein 0.318088
PLGRKT plasminogen receptor, C-terminal lysine transmembrane protein 0.317627
ZNF451 zinc finger protein 451 0.317346
WWOX WW domain containing oxidoreductase 0.314547
MACROD2 MACRO domain containing 2 0.314202
BEST3 bestrophin 3 0.31278
MORN5 MORN repeat containing 5 0.311809
STMN2 stathmin 2 0.309747
TP73 tumor protein p73 0.308801
ZPBP zona pellucida binding protein 0.308552
MTCH1 mitochondrial carrier 1 0.308511
LOC401324 uncharacterized LOC401324 0.307825
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.306825
UBAC2 UBA domain containing 2 0.306202
FNDC1 fibronectin type III domain containing 1 0.306058
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.305531
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.30512
TMEM44 transmembrane protein 44 0.304069
ST8SIA5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 0.303974
APCDD1L adenomatosis polyposis coli down-regulated 1-like 0.302489
NTN1 netrin 1 0.301921
MSRA methionine sulfoxide reductase A 0.300296
PRR5L proline rich 5 like 0.29956
UBASH3B ubiquitin associated and SH3 domain containing B 0.29781
MS4A10 membrane-spanning 4-domains, subfamily A, member 10 0.294973