grb2 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description growth factor receptor-bound protein 2|The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 2885)
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Genes

84 genes co-occuring with the biological term grb2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ADAM12 ADAM metallopeptidase domain 12
ADAM15 ADAM metallopeptidase domain 15
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALK anaplastic lymphoma receptor tyrosine kinase
APP amyloid beta (A4) precursor protein
ARF1 ADP-ribosylation factor 1
ARF6 ADP-ribosylation factor 6
ASAP3 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
BCR breakpoint cluster region
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAT catalase
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase
CD19 CD19 molecule
CD28 CD28 molecule
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CSH1 chorionic somatomammotropin hormone 1 (placental lactogen)
CSK c-src tyrosine kinase
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK3 docking protein 3
EGFR epidermal growth factor receptor
EPHA2 EPH receptor A2
ERBB3 erb-b2 receptor tyrosine kinase 3
ERBB4 erb-b2 receptor tyrosine kinase 4
FASLG Fas ligand (TNF superfamily, member 6)
FGFR2 fibroblast growth factor receptor 2
GAB1 GRB2-associated binding protein 1
GAB2 GRB2-associated binding protein 2
GRAP GRB2-related adaptor protein
GRAP2 GRB2-related adaptor protein 2
GRB2 growth factor receptor-bound protein 2
GRB7 growth factor receptor-bound protein 7
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
IGF1 insulin-like growth factor 1 (somatomedin C)
INSR insulin receptor
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
KIRREL kin of IRRE like (Drosophila)
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KRAS Kirsten rat sarcoma viral oncogene homolog
LAT linker for activation of T cells
LAT2 linker for activation of T cells family, member 2
LCK LCK proto-oncogene, Src family tyrosine kinase
LEP leptin
LY6G6F lymphocyte antigen 6 complex, locus G6F
LY9 lymphocyte antigen 9
MADD MAP-kinase activating death domain
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MED28 mediator complex subunit 28
MET MET proto-oncogene, receptor tyrosine kinase
MIR376C microRNA 376c
MST1R macrophage stimulating 1 receptor
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NEU3 sialidase 3 (membrane sialidase)
NFAM1 NFAT activating protein with ITAM motif 1
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PLCG1 phospholipase C, gamma 1
PLD2 phospholipase D2
PNRC1 proline-rich nuclear receptor coactivator 1
PRKAB1 protein kinase, AMP-activated, beta 1 non-catalytic subunit
PTK2 protein tyrosine kinase 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPN23 protein tyrosine phosphatase, non-receptor type 23
PXN paxillin
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SPRY2 sprouty homolog 2 (Drosophila)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STAMBPL1 STAM binding protein-like 1
THEMIS thymocyte selection associated
TNF tumor necrosis factor
UVRAG UV radiation resistance associated
VAV1 vav 1 guanine nucleotide exchange factor
WNT1 wingless-type MMTV integration site family, member 1