guaifenesin-3897 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the guaifenesin-3897 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACRV1 acrosomal vesicle protein 1
ADM2 adrenomedullin 2
AK1 adenylate kinase 1
ALX3 ALX homeobox 3
APAF1 apoptotic peptidase activating factor 1
APBA1 amyloid beta (A4) precursor protein-binding, family A, member 1
BTNL3 butyrophilin-like 3
C17ORF53 chromosome 17 open reading frame 53
CAPZB capping protein (actin filament) muscle Z-line, beta
CDA cytidine deaminase
CDC42 cell division cycle 42
CLCA2 chloride channel accessory 2
CLEC7A C-type lectin domain family 7, member A
CNTN1 contactin 1
COL17A1 collagen, type XVII, alpha 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYTH1 cytohesin 1
DICER1 dicer 1, ribonuclease type III
DPF1 D4, zinc and double PHD fingers family 1
DRD2 dopamine receptor D2
FBXO2 F-box protein 2
FGD1 FYVE, RhoGEF and PH domain containing 1
FGFR3 fibroblast growth factor receptor 3
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
GGT1 gamma-glutamyltransferase 1
GSK3A glycogen synthase kinase 3 alpha
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HIST1H4A histone cluster 1, H4a
HOXB5 homeobox B5
IFNA17 interferon, alpha 17
IL20RA interleukin 20 receptor, alpha
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
JAM3 junctional adhesion molecule 3
KCNIP1 Kv channel interacting protein 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KIAA1456 KIAA1456
KLF12 Kruppel-like factor 12
KLHL29 kelch-like family member 29
L3MBTL1 l(3)mbt-like 1 (Drosophila)
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LLGL1 lethal giant larvae homolog 1 (Drosophila)
MATN3 matrilin 3
MED25 mediator complex subunit 25
MMP11 matrix metallopeptidase 11
MMP13 matrix metallopeptidase 13
MR1 major histocompatibility complex, class I-related
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MST1 macrophage stimulating 1
MX1 MX dynamin-like GTPase 1
NR6A1 nuclear receptor subfamily 6, group A, member 1
OSBPL3 oxysterol binding protein-like 3
OXCT2 3-oxoacid CoA transferase 2
PAH phenylalanine hydroxylase
PAX8 paired box 8
PCDHGC3 protocadherin gamma subfamily C, 3
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM5 PDZ and LIM domain 5
PEG10 paternally expressed 10
PKD1 polycystic kidney disease 1 (autosomal dominant)
PLCH1 phospholipase C, eta 1
PLK3 polo-like kinase 3
PLXNC1 plexin C1
PML promyelocytic leukemia
PRAME preferentially expressed antigen in melanoma
PRB4 proline-rich protein BstNI subfamily 4
PRKCB protein kinase C, beta
PSCA prostate stem cell antigen
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAB6B RAB6B, member RAS oncogene family
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SAG S-antigen; retina and pineal gland (arrestin)
SFTPB surfactant protein B
SH3BP2 SH3-domain binding protein 2
SH3GL3 SH3-domain GRB2-like 3
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC15A1 solute carrier family 15 (oligopeptide transporter), member 1
SLC19A1 solute carrier family 19 (folate transporter), member 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLPI secretory leukocyte peptidase inhibitor
SPP1 secreted phosphoprotein 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAT4 signal transducer and activator of transcription 4
STX7 syntaxin 7
SYNGR4 synaptogyrin 4
THY1 Thy-1 cell surface antigen
TJAP1 tight junction associated protein 1 (peripheral)
TMOD1 tropomodulin 1
TMPRSS6 transmembrane protease, serine 6
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TONSL tonsoku-like, DNA repair protein
TPSG1 tryptase gamma 1
TRA T cell receptor alpha locus
TUBA3C tubulin, alpha 3c
VASH1 vasohibin 1
ZFP2 ZFP2 zinc finger protein
ZNF484 zinc finger protein 484

decreased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
C11ORF30 chromosome 11 open reading frame 30
C1ORF106 chromosome 1 open reading frame 106
C5AR1 complement component 5a receptor 1
C8ORF44 chromosome 8 open reading frame 44
CCDC71 coiled-coil domain containing 71
CCDC85C coiled-coil domain containing 85C
CD1A CD1a molecule
CD3D CD3d molecule, delta (CD3-TCR complex)
CD82 CD82 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLDN1 claudin 1
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DEAF1 DEAF1 transcription factor
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DRD1 dopamine receptor D1
DUSP5 dual specificity phosphatase 5
EGR3 early growth response 3
ENO3 enolase 3 (beta, muscle)
FAM110B family with sequence similarity 110, member B
FARP2 FERM, RhoGEF and pleckstrin domain protein 2
FKRP fukutin related protein
FLJ11710 uncharacterized protein FLJ11710
FOSL1 FOS-like antigen 1
FOXI1 forkhead box I1
FRMD1 FERM domain containing 1
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GADD45G growth arrest and DNA-damage-inducible, gamma
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
GJA9 gap junction protein, alpha 9, 59kDa
GLB1L galactosidase, beta 1-like
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPR157 G protein-coupled receptor 157
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HDAC11 histone deacetylase 11
HDAC7 histone deacetylase 7
HSF4 heat shock transcription factor 4
IL12RB1 interleukin 12 receptor, beta 1
IL4R interleukin 4 receptor
IQCC IQ motif containing C
IQSEC2 IQ motif and Sec7 domain 2
KIAA0319L KIAA0319-like
KIF13A kinesin family member 13A
KLK8 kallikrein-related peptidase 8
KRT15 keratin 15, type I
LIF leukemia inhibitory factor
LRP5L low density lipoprotein receptor-related protein 5-like
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
LZTS3 leucine zipper, putative tumor suppressor family member 3
MALL mal, T-cell differentiation protein-like
MAOB monoamine oxidase B
MAPK10 mitogen-activated protein kinase 10
MBNL3 muscleblind-like splicing regulator 3
MFSD6 major facilitator superfamily domain containing 6
N4BP3 NEDD4 binding protein 3
NAT6 N-acetyltransferase 6 (GCN5-related)
NME5 NME/NM23 family member 5
NPPA natriuretic peptide A
NPTX1 neuronal pentraxin I
ONECUT2 one cut homeobox 2
OSGIN1 oxidative stress induced growth inhibitor 1
OSMR oncostatin M receptor
PCDHGA8 protocadherin gamma subfamily A, 8
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PLA2G3 phospholipase A2, group III
PLCD1 phospholipase C, delta 1
PLD2 phospholipase D2
PLXNB3 plexin B3
PPARG peroxisome proliferator-activated receptor gamma
PRAMEF11 PRAME family member 11
QPCT glutaminyl-peptide cyclotransferase
RAI2 retinoic acid induced 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RND1 Rho family GTPase 1
SCD5 stearoyl-CoA desaturase 5
SERGEF secretion regulating guanine nucleotide exchange factor
SH3TC1 SH3 domain and tetratricopeptide repeats 1
SIGLEC15 sialic acid binding Ig-like lectin 15
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
SMEK2 SMEK homolog 2, suppressor of mek1 (Dictyostelium)
SMIM14 small integral membrane protein 14
SPRY2 sprouty homolog 2 (Drosophila)
SPTBN2 spectrin, beta, non-erythrocytic 2
SYNC syncoilin, intermediate filament protein
TARP TCR gamma alternate reading frame protein
TCP10 t-complex 10
TFF2 trefoil factor 2
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TNS3 tensin 3
TRAIP TRAF interacting protein
TRPV6 transient receptor potential cation channel, subfamily V, member 6
UPK2 uroplakin 2
USB1 U6 snRNA biogenesis 1
WDR4 WD repeat domain 4
ZSWIM1 zinc finger, SWIM-type containing 1