guanadrel-2575 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the guanadrel-2575 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AGER advanced glycosylation end product-specific receptor
AIF1 allograft inflammatory factor 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMH anti-Mullerian hormone
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
AP2A2 adaptor-related protein complex 2, alpha 2 subunit
BIRC3 baculoviral IAP repeat containing 3
C11ORF16 chromosome 11 open reading frame 16
CALD1 caldesmon 1
CCDC102B coiled-coil domain containing 102B
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD6 CD6 molecule
CHD9 chromodomain helicase DNA binding protein 9
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal)
CHRNG cholinergic receptor, nicotinic, gamma (muscle)
COMMD4 COMM domain containing 4
CRABP1 cellular retinoic acid binding protein 1
CRP C-reactive protein, pentraxin-related
CTBP2 C-terminal binding protein 2
DDX28 DEAD (Asp-Glu-Ala-Asp) box polypeptide 28
DHRS12 dehydrogenase/reductase (SDR family) member 12
DNMBP dynamin binding protein
FAM63B family with sequence similarity 63, member B
FBXO2 F-box protein 2
FGF5 fibroblast growth factor 5
FGF9 fibroblast growth factor 9
FGL1 fibrinogen-like 1
FLJ11292
FLRT1 fibronectin leucine rich transmembrane protein 1
FUS FUS RNA binding protein
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GAP43 growth associated protein 43
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPRIN2 G protein regulated inducer of neurite outgrowth 2
HIST1H4A histone cluster 1, H4a
HN1L hematological and neurological expressed 1-like
HOXA10 homeobox A10
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
ICAM5 intercellular adhesion molecule 5, telencephalin
IFITM1 interferon induced transmembrane protein 1
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
KALRN kalirin, RhoGEF kinase
KIF5C kinesin family member 5C
KIR2DL5A killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
KMT2A lysine (K)-specific methyltransferase 2A
LAD1 ladinin 1
LARP7 La ribonucleoprotein domain family, member 7
LGALS14 lectin, galactoside-binding, soluble, 14
LRP6 low density lipoprotein receptor-related protein 6
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MEG3 maternally expressed 3 (non-protein coding)
MRC2 mannose receptor, C type 2
MYH14 myosin, heavy chain 14, non-muscle
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NEURL1 neuralized E3 ubiquitin protein ligase 1
NOP14-AS1 NOP14 antisense RNA 1
NOVA2 neuro-oncological ventral antigen 2
NQO1 NAD(P)H dehydrogenase, quinone 1
OGFR opioid growth factor receptor
OLFM1 olfactomedin 1
PARD3 par-3 family cell polarity regulator
PCDHGA3 protocadherin gamma subfamily A, 3
PDE4A phosphodiesterase 4A, cAMP-specific
PDE4D phosphodiesterase 4D, cAMP-specific
PDLIM7 PDZ and LIM domain 7 (enigma)
PHACTR1 phosphatase and actin regulator 1
PHF20L1 PHD finger protein 20-like 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PKP4 plakophilin 4
PLA2G15 phospholipase A2, group XV
PPP5C protein phosphatase 5, catalytic subunit
PTK2B protein tyrosine kinase 2 beta
PTRF polymerase I and transcript release factor
RBPMS RNA binding protein with multiple splicing
RDH8 retinol dehydrogenase 8 (all-trans)
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
SCARB2 scavenger receptor class B, member 2
SCN5A sodium channel, voltage gated, type V alpha subunit
SEMA6C sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC35F6 solute carrier family 35, member F6
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2
SMURF1 SMAD specific E3 ubiquitin protein ligase 1
SPEG SPEG complex locus
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STXBP5L syntaxin binding protein 5-like
TACSTD2 tumor-associated calcium signal transducer 2
THSD7A thrombospondin, type I, domain containing 7A
TMEM19 transmembrane protein 19
TMEM206 transmembrane protein 206
TMEM63A transmembrane protein 63A
TRIM23 tripartite motif containing 23
TSHB thyroid stimulating hormone, beta
YY2 YY2 transcription factor
ZC3H13 zinc finger CCCH-type containing 13
ZNF155 zinc finger protein 155

decreased expression

Symbol Name
ADAM15 ADAM metallopeptidase domain 15
ADAM2 ADAM metallopeptidase domain 2
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AIRE autoimmune regulator
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle)
ANXA3 annexin A3
APOBR apolipoprotein B receptor
APOL6 apolipoprotein L, 6
C22ORF46 chromosome 22 open reading frame 46
C5 complement component 5
C5AR1 complement component 5a receptor 1
C9ORF3 chromosome 9 open reading frame 3
CBX8 chromobox homolog 8
CCDC69 coiled-coil domain containing 69
CCDC88C coiled-coil domain containing 88C
CD82 CD82 molecule
CDON cell adhesion associated, oncogene regulated
CFAP69 cilia and flagella associated protein 69
CHML choroideremia-like (Rab escort protein 2)
CHRNA10 cholinergic receptor, nicotinic, alpha 10 (neuronal)
CNKSR2 connector enhancer of kinase suppressor of Ras 2
CTSO cathepsin O
CYHR1 cysteine/histidine-rich 1
DDN dendrin
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
ENO3 enolase 3 (beta, muscle)
F13A1 coagulation factor XIII, A1 polypeptide
FAM184A family with sequence similarity 184, member A
FGF6 fibroblast growth factor 6
FJX1 four jointed box 1 (Drosophila)
FLJ21369 uncharacterized protein FLJ21369
FLT4 fms-related tyrosine kinase 4
GCH1 GTP cyclohydrolase 1
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GSTT1 glutathione S-transferase theta 1
HOXC8 homeobox C8
IGKV3-20 immunoglobulin kappa variable 3-20
INHBE inhibin, beta E
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITPKC inositol-trisphosphate 3-kinase C
KIAA1024 KIAA1024
KIF13B kinesin family member 13B
KLHL36 kelch-like family member 36
LINC00260 long intergenic non-protein coding RNA 260
LOC100287590 uncharacterized LOC100287590
LPPR1 lipid phosphate phosphatase-related protein type 1
LTBP3 latent transforming growth factor beta binding protein 3
LY6D lymphocyte antigen 6 complex, locus D
MAGEF1 melanoma antigen family F1
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MBTPS2 membrane-bound transcription factor peptidase, site 2
ME3 malic enzyme 3, NADP(+)-dependent, mitochondrial
MGP matrix Gla protein
MRPS18C mitochondrial ribosomal protein S18C
MTSS1L metastasis suppressor 1-like
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
NDE1 nudE neurodevelopment protein 1
NOD2 nucleotide-binding oligomerization domain containing 2
NOL10 nucleolar protein 10
OCEL1 occludin/ELL domain containing 1
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
PAIP2B poly(A) binding protein interacting protein 2B
PCDH12 protocadherin 12
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PDLIM1 PDZ and LIM domain 1
PER3 period circadian clock 3
PMFBP1 polyamine modulated factor 1 binding protein 1
PRDM12 PR domain containing 12
PRR7 proline rich 7 (synaptic)
PTGIR prostaglandin I2 (prostacyclin) receptor (IP)
QPCT glutaminyl-peptide cyclotransferase
REPS2 RALBP1 associated Eps domain containing 2
RETN resistin
RFXAP regulatory factor X-associated protein
SERGEF secretion regulating guanine nucleotide exchange factor
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SIGLEC9 sialic acid binding Ig-like lectin 9
SIRT2 sirtuin 2
SLC12A8 solute carrier family 12, member 8
SLC44A1 solute carrier family 44 (choline transporter), member 1
SLCO1B1 solute carrier organic anion transporter family, member 1B1
SLFN12 schlafen family member 12
SNX16 sorting nexin 16
SPIDR scaffolding protein involved in DNA repair
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
STMN4 stathmin-like 4
TBXAS1 thromboxane A synthase 1 (platelet)
TLR8 toll-like receptor 8
TMA16 translation machinery associated 16 homolog (S. cerevisiae)
TMEM53 transmembrane protein 53
TNFRSF8 tumor necrosis factor receptor superfamily, member 8
TNNT1 troponin T type 1 (skeletal, slow)
TNS2 tensin 2
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
ZBTB22 zinc finger and BTB domain containing 22
ZNF280A zinc finger protein 280A
ZNF34 zinc finger protein 34
ZNF668 zinc finger protein 668
ZNF76 zinc finger protein 76