guanadrel-7396 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

197 genes differentially expressed following the guanadrel-7396 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABI2 abl-interactor 2
ADTRP androgen-dependent TFPI-regulating protein
ALOXE3 arachidonate lipoxygenase 3
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2
BBC3 BCL2 binding component 3
CACNB3 calcium channel, voltage-dependent, beta 3 subunit
CASP1 caspase 1, apoptosis-related cysteine peptidase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCDC85C coiled-coil domain containing 85C
CDHR2 cadherin-related family member 2
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal)
COX6A2 cytochrome c oxidase subunit VIa polypeptide 2
CRMP1 collapsin response mediator protein 1
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTNND2 catenin (cadherin-associated protein), delta 2
DAGLA diacylglycerol lipase, alpha
DCAF15 DDB1 and CUL4 associated factor 15
DHRS12 dehydrogenase/reductase (SDR family) member 12
DIMT1 DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae)
DNASE1L3 deoxyribonuclease I-like 3
ELL elongation factor RNA polymerase II
EMID1 EMI domain containing 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
EPM2A epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
EXOG endo/exonuclease (5'-3'), endonuclease G-like
F2RL3 coagulation factor II (thrombin) receptor-like 3
FAM110D family with sequence similarity 110, member D
FAM3A family with sequence similarity 3, member A
FAM65A family with sequence similarity 65, member A
FAM65B family with sequence similarity 65, member B
FBXL18 F-box and leucine-rich repeat protein 18
FGF22 fibroblast growth factor 22
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GAS8 growth arrest-specific 8
GGA2 golgi-associated, gamma adaptin ear containing, ARF binding protein 2
GLRX3 glutaredoxin 3
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPR137 G protein-coupled receptor 137
GRK4 G protein-coupled receptor kinase 4
GRTP1 growth hormone regulated TBC protein 1
HOXA4 homeobox A4
HOXD13 homeobox D13
KALRN kalirin, RhoGEF kinase
KLF4 Kruppel-like factor 4 (gut)
KLK13 kallikrein-related peptidase 13
LIMK2 LIM domain kinase 2
LMCD1 LIM and cysteine-rich domains 1
MED16 mediator complex subunit 16
MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
MR1 major histocompatibility complex, class I-related
MRPS12 mitochondrial ribosomal protein S12
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTA2 metastasis associated 1 family, member 2
N4BP1 NEDD4 binding protein 1
NCOR2 nuclear receptor corepressor 2
NEK11 NIMA-related kinase 11
NEK3 NIMA-related kinase 3
NF2 neurofibromin 2 (merlin)
NR2F6 nuclear receptor subfamily 2, group F, member 6
NR4A1 nuclear receptor subfamily 4, group A, member 1
PARP11 poly (ADP-ribose) polymerase family, member 11
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDZK1 PDZ domain containing 1
PLK4 polo-like kinase 4
PLXNB3 plexin B3
RPL7 ribosomal protein L7
RUNX3 runt-related transcription factor 3
SAFB2 scaffold attachment factor B2
SARS2 seryl-tRNA synthetase 2, mitochondrial
SCD5 stearoyl-CoA desaturase 5
SCGB2A2 secretoglobin, family 2A, member 2
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SETDB1 SET domain, bifurcated 1
SKIL SKI-like proto-oncogene
SLAMF7 SLAM family member 7
SLC20A2 solute carrier family 20 (phosphate transporter), member 2
SLC2A9 solute carrier family 2 (facilitated glucose transporter), member 9
SOX4 SRY (sex determining region Y)-box 4
SRSF5 serine/arginine-rich splicing factor 5
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae)
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYN2 synapsin II
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
TAOK1 TAO kinase 1
TBCD tubulin folding cofactor D
TCTN2 tectonic family member 2
THRA thyroid hormone receptor, alpha
TLE4 transducin-like enhancer of split 4
TMEM19 transmembrane protein 19
UBE3B ubiquitin protein ligase E3B
VCL vinculin
WDR25 WD repeat domain 25
ZNF407 zinc finger protein 407
ZNF428 zinc finger protein 428
ZNF516 zinc finger protein 516
ZNF549 zinc finger protein 549
ZNF778 zinc finger protein 778

decreased expression

Symbol Name
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2
ANKRD36 ankyrin repeat domain 36
APOL6 apolipoprotein L, 6
ARID3B AT rich interactive domain 3B (BRIGHT-like)
ASB8 ankyrin repeat and SOCS box containing 8
ATP11B ATPase, class VI, type 11B
ATXN2 ataxin 2
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1
BRWD1 bromodomain and WD repeat domain containing 1
C16ORF62 chromosome 16 open reading frame 62
C17ORF62 chromosome 17 open reading frame 62
C19ORF40 chromosome 19 open reading frame 40
C7ORF43 chromosome 7 open reading frame 43
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC106 coiled-coil domain containing 106
CCDC69 coiled-coil domain containing 69
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CDK3 cyclin-dependent kinase 3
CDK6 cyclin-dependent kinase 6
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle)
CYB5R4 cytochrome b5 reductase 4
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNMBP dynamin binding protein
DUSP8 dual specificity phosphatase 8
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
DZANK1 double zinc ribbon and ankyrin repeat domains 1
ELP3 elongator acetyltransferase complex subunit 3
EN2 engrailed homeobox 2
F3 coagulation factor III (thromboplastin, tissue factor)
GALK1 galactokinase 1
GAREM GRB2 associated, regulator of MAPK1
GDAP1 ganglioside induced differentiation associated protein 1
GFOD2 glucose-fructose oxidoreductase domain containing 2
GTF2I general transcription factor IIi
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HIST1H2BO histone cluster 1, H2bo
HIST1H3A histone cluster 1, H3a
HIST1H3G histone cluster 1, H3g
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INF2 inverted formin, FH2 and WH2 domain containing
ISL1 ISL LIM homeobox 1
ITPKC inositol-trisphosphate 3-kinase C
KBTBD4 kelch repeat and BTB (POZ) domain containing 4
KIAA0556 KIAA0556
KIAA0922 KIAA0922
KIAA1107 KIAA1107
KRT15 keratin 15, type I
KRT34 keratin 34, type I
LINS lines homolog (Drosophila)
LRRC61 leucine rich repeat containing 61
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MAP3K12 mitogen-activated protein kinase kinase kinase 12
MTERF4 mitochondrial transcription termination factor 4
MTMR11 myotubularin related protein 11
MUM1 melanoma associated antigen (mutated) 1
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric
MYO1D myosin ID
NDE1 nudE neurodevelopment protein 1
NOTCH1 notch 1
NPDC1 neural proliferation, differentiation and control, 1
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
OR7E47P olfactory receptor, family 7, subfamily E, member 47 pseudogene
OTUD3 OTU deubiquitinase 3
OVGP1 oviductal glycoprotein 1, 120kDa
PIBF1 progesterone immunomodulatory binding factor 1
PLAC8 placenta-specific 8
PPL periplakin
RAB8B RAB8B, member RAS oncogene family
RIN1 Ras and Rab interactor 1
SCUBE3 signal peptide, CUB domain, EGF-like 3
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD3 SERTA domain containing 3
SETD6 SET domain containing 6
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1
SLITRK5 SLIT and NTRK-like family, member 5
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
TBC1D19 TBC1 domain family, member 19
TESK1 testis-specific kinase 1
TGFBI transforming growth factor, beta-induced, 68kDa
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TLR2 toll-like receptor 2
TMEM212 transmembrane protein 212
TMEM38B transmembrane protein 38B
TMEM8B transmembrane protein 8B
TRAPPC2 trafficking protein particle complex 2
USB1 U6 snRNA biogenesis 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
WDR47 WD repeat domain 47
XYLT2 xylosyltransferase II
ZBTB39 zinc finger and BTB domain containing 39
ZDHHC11 zinc finger, DHHC-type containing 11
ZNF226 zinc finger protein 226
ZNF254 zinc finger protein 254
ZNF280D zinc finger protein 280D