| Dataset | CMAP Signatures of Differentially Expressed Genes for Small Molecules |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis) |
| Similar Terms | |
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197 genes differentially expressed following the guanfacine-5621 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.
| Symbol | Name |
|---|---|
| ADGB | androglobin |
| AIM2 | absent in melanoma 2 |
| AMH | anti-Mullerian hormone |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) |
| AP3B2 | adaptor-related protein complex 3, beta 2 subunit |
| APOBEC1 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 |
| APOBEC2 | apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 |
| ASAP3 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 3 |
| CCL22 | chemokine (C-C motif) ligand 22 |
| CCL24 | chemokine (C-C motif) ligand 24 |
| CHRNA4 | cholinergic receptor, nicotinic, alpha 4 (neuronal) |
| CLCN7 | chloride channel, voltage-sensitive 7 |
| CLTA | clathrin, light chain A |
| CXCL8 | chemokine (C-X-C motif) ligand 8 |
| CXCR2 | chemokine (C-X-C motif) receptor 2 |
| CYP2C9 | cytochrome P450, family 2, subfamily C, polypeptide 9 |
| DAB2 | Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) |
| DBH | dopamine beta-hydroxylase (dopamine beta-monooxygenase) |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 |
| DCT | dopachrome tautomerase |
| DNAI2 | dynein, axonemal, intermediate chain 2 |
| DYNC1LI2 | dynein, cytoplasmic 1, light intermediate chain 2 |
| EDNRB | endothelin receptor type B |
| ENTPD3 | ectonucleoside triphosphate diphosphohydrolase 3 |
| EPB41 | erythrocyte membrane protein band 4.1 |
| EVA1B | eva-1 homolog B (C. elegans) |
| FBXO41 | F-box protein 41 |
| FGF13 | fibroblast growth factor 13 |
| FHL1 | four and a half LIM domains 1 |
| FPR1 | formyl peptide receptor 1 |
| FRS3 | fibroblast growth factor receptor substrate 3 |
| GABBR2 | gamma-aminobutyric acid (GABA) B receptor, 2 |
| HIST1H2AI | histone cluster 1, H2ai |
| IFFO1 | intermediate filament family orphan 1 |
| IL1RAP | interleukin 1 receptor accessory protein |
| IL24 | interleukin 24 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) |
| ITIH5 | inter-alpha-trypsin inhibitor heavy chain family, member 5 |
| KIF13A | kinesin family member 13A |
| KIT | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog |
| KRT83 | keratin 83, type II |
| L3MBTL1 | l(3)mbt-like 1 (Drosophila) |
| LAMP1 | lysosomal-associated membrane protein 1 |
| LILRA6 | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 |
| LIM2 | lens intrinsic membrane protein 2, 19kDa |
| LRRC8B | leucine rich repeat containing 8 family, member B |
| MAOA | monoamine oxidase A |
| MAOB | monoamine oxidase B |
| MAP2K7 | mitogen-activated protein kinase kinase 7 |
| MC5R | melanocortin 5 receptor |
| MIOS | missing oocyte, meiosis regulator, homolog (Drosophila) |
| MUC5B | mucin 5B, oligomeric mucus/gel-forming |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow |
| NDUFA2 | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa |
| NEFM | neurofilament, medium polypeptide |
| NEK9 | NIMA-related kinase 9 |
| NOTCH3 | notch 3 |
| OR10H1 | olfactory receptor, family 10, subfamily H, member 1 |
| PAPPA2 | pappalysin 2 |
| PCDHB12 | protocadherin beta 12 |
| PCSK6 | proprotein convertase subtilisin/kexin type 6 |
| PDCD2 | programmed cell death 2 |
| PENK | proenkephalin |
| PLXNB3 | plexin B3 |
| PLXNC1 | plexin C1 |
| PRX | periaxin |
| PTGDR2 | prostaglandin D2 receptor 2 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 |
| RMND5A | required for meiotic nuclear division 5 homolog A (S. cerevisiae) |
| RND1 | Rho family GTPase 1 |
| RPS6KA6 | ribosomal protein S6 kinase, 90kDa, polypeptide 6 |
| SCNN1B | sodium channel, non voltage gated 1 beta subunit |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A |
| SERHL2 | serine hydrolase-like 2 |
| SIGLEC8 | sialic acid binding Ig-like lectin 8 |
| SIT1 | signaling threshold regulating transmembrane adaptor 1 |
| SLC24A1 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 |
| SLC2A5 | solute carrier family 2 (facilitated glucose/fructose transporter), member 5 |
| SLC30A3 | solute carrier family 30 (zinc transporter), member 3 |
| SPON2 | spondin 2, extracellular matrix protein |
| SRSF5 | serine/arginine-rich splicing factor 5 |
| STK11 | serine/threonine kinase 11 |
| SYN2 | synapsin II |
| TAAR2 | trace amine associated receptor 2 |
| TAF6L | TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa |
| TAPBP | TAP binding protein (tapasin) |
| TAS2R4 | taste receptor, type 2, member 4 |
| TFDP3 | transcription factor Dp family, member 3 |
| TPSG1 | tryptase gamma 1 |
| TRO | trophinin |
| TUBB2B | tubulin, beta 2B class IIb |
| UCHL1 | ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) |
| VWA5A | von Willebrand factor A domain containing 5A |
| WDR55 | WD repeat domain 55 |
| WDR62 | WD repeat domain 62 |
| WSCD1 | WSC domain containing 1 |
| ZMIZ2 | zinc finger, MIZ-type containing 2 |
| ZNF230 | zinc finger protein 230 |
| Symbol | Name |
|---|---|
| ACAD10 | acyl-CoA dehydrogenase family, member 10 |
| ADAP2 | ArfGAP with dual PH domains 2 |
| ADTRP | androgen-dependent TFPI-regulating protein |
| AMT | aminomethyltransferase |
| ARMC4 | armadillo repeat containing 4 |
| ARPIN | actin-related protein 2/3 complex inhibitor |
| AUTS2 | autism susceptibility candidate 2 |
| BAHCC1 | BAH domain and coiled-coil containing 1 |
| BMP4 | bone morphogenetic protein 4 |
| BTF3P11 | basic transcription factor 3 pseudogene 11 |
| CCDC71 | coiled-coil domain containing 71 |
| CDK3 | cyclin-dependent kinase 3 |
| CES3 | carboxylesterase 3 |
| CHST8 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 |
| CIDEB | cell death-inducing DFFA-like effector b |
| CPNE7 | copine VII |
| CRLF1 | cytokine receptor-like factor 1 |
| CYP4F11 | cytochrome P450, family 4, subfamily F, polypeptide 11 |
| DNAJA4 | DnaJ (Hsp40) homolog, subfamily A, member 4 |
| DOK5 | docking protein 5 |
| DSPP | dentin sialophosphoprotein |
| EPN1 | epsin 1 |
| ETV6 | ets variant 6 |
| F2R | coagulation factor II (thrombin) receptor |
| FADS2 | fatty acid desaturase 2 |
| FAM120C | family with sequence similarity 120C |
| FILIP1L | filamin A interacting protein 1-like |
| GAMT | guanidinoacetate N-methyltransferase |
| GAREM | GRB2 associated, regulator of MAPK1 |
| GJA8 | gap junction protein, alpha 8, 50kDa |
| GMPR | guanosine monophosphate reductase |
| GNA15 | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) |
| HAMP | hepcidin antimicrobial peptide |
| HDAC5 | histone deacetylase 5 |
| HIST1H3B | histone cluster 1, H3b |
| HIST1H4E | histone cluster 1, H4e |
| HTR1E | 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled |
| IL2 | interleukin 2 |
| IQSEC2 | IQ motif and Sec7 domain 2 |
| KANSL1L | KAT8 regulatory NSL complex subunit 1-like |
| KCNK12 | potassium channel, two pore domain subfamily K, member 12 |
| KCTD17 | potassium channel tetramerization domain containing 17 |
| KIAA0319L | KIAA0319-like |
| LAMP3 | lysosomal-associated membrane protein 3 |
| LINC00597 | long intergenic non-protein coding RNA 597 |
| MATK | megakaryocyte-associated tyrosine kinase |
| MNX1 | motor neuron and pancreas homeobox 1 |
| OR1G1 | olfactory receptor, family 1, subfamily G, member 1 |
| OVOL1 | ovo-like zinc finger 1 |
| PCDHB13 | protocadherin beta 13 |
| PDE6C | phosphodiesterase 6C, cGMP-specific, cone, alpha prime |
| PDE8B | phosphodiesterase 8B |
| PNPLA6 | patatin-like phospholipase domain containing 6 |
| PODXL2 | podocalyxin-like 2 |
| POM121 | POM121 transmembrane nucleoporin |
| PPT2 | palmitoyl-protein thioesterase 2 |
| PRF1 | perforin 1 (pore forming protein) |
| PTTG3P | pituitary tumor-transforming 3, pseudogene |
| RABL6 | RAB, member RAS oncogene family-like 6 |
| RHBDF2 | rhomboid 5 homolog 2 (Drosophila) |
| RHOBTB2 | Rho-related BTB domain containing 2 |
| RNF125 | ring finger protein 125, E3 ubiquitin protein ligase |
| RNF39 | ring finger protein 39 |
| S100A2 | S100 calcium binding protein A2 |
| S100A9 | S100 calcium binding protein A9 |
| SGCG | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) |
| SIX1 | SIX homeobox 1 |
| SLC3A1 | solute carrier family 3 (amino acid transporter heavy chain), member 1 |
| SLIT2 | slit homolog 2 (Drosophila) |
| SMIM14 | small integral membrane protein 14 |
| SNAPC2 | small nuclear RNA activating complex, polypeptide 2, 45kDa |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 |
| SRD5A3 | steroid 5 alpha-reductase 3 |
| SSTR4 | somatostatin receptor 4 |
| SULT4A1 | sulfotransferase family 4A, member 1 |
| SUN2 | Sad1 and UNC84 domain containing 2 |
| TAB1 | TGF-beta activated kinase 1/MAP3K7 binding protein 1 |
| TAF4B | TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa |
| TAGLN | transgelin |
| TBC1D31 | TBC1 domain family, member 31 |
| TCEB3B | transcription elongation factor B polypeptide 3B (elongin A2) |
| TCHH | trichohyalin |
| TMEM104 | transmembrane protein 104 |
| TMEM53 | transmembrane protein 53 |
| TRABD | TraB domain containing |
| TRAPPC11 | trafficking protein particle complex 11 |
| TUBA3C | tubulin, alpha 3c |
| UBXN6 | UBX domain protein 6 |
| USP5 | ubiquitin specific peptidase 5 (isopeptidase T) |
| VPS11 | vacuolar protein sorting 11 homolog (S. cerevisiae) |
| ZBTB33 | zinc finger and BTB domain containing 33 |
| ZCWPW1 | zinc finger, CW type with PWWP domain 1 |
| ZNF250 | zinc finger protein 250 |
| ZNF286A | zinc finger protein 286A |
| ZNF34 | zinc finger protein 34 |
| ZNF442 | zinc finger protein 442 |
| ZNF532 | zinc finger protein 532 |
| ZNF701 | zinc finger protein 701 |
| ZNF711 | zinc finger protein 711 |
