halofantrine-7469 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the halofantrine-7469 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ADAP1 ArfGAP with dual PH domains 1
ADAP2 ArfGAP with dual PH domains 2
ADCY6 adenylate cyclase 6
ALG12 ALG12, alpha-1,6-mannosyltransferase
APOE apolipoprotein E
AQP3 aquaporin 3 (Gill blood group)
ATP10A ATPase, class V, type 10A
AURKA aurora kinase A
C1QTNF9B-AS1 C1QTNF9B antisense RNA 1
CA5BP1 carbonic anhydrase VB pseudogene 1
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CCDC25 coiled-coil domain containing 25
CCDC71 coiled-coil domain containing 71
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDON cell adhesion associated, oncogene regulated
CEP104 centrosomal protein 104kDa
CLCA1 chloride channel accessory 1
CREM cAMP responsive element modulator
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSF1 colony stimulating factor 1 (macrophage)
DUSP9 dual specificity phosphatase 9
EMID1 EMI domain containing 1
EPHA1 EPH receptor A1
FAM149B1 family with sequence similarity 149, member B1
FAM204A family with sequence similarity 204, member A
FANCA Fanconi anemia, complementation group A
FBXL7 F-box and leucine-rich repeat protein 7
FHL1 four and a half LIM domains 1
FLJ42627 uncharacterized LOC645644
FLNC filamin C, gamma
FLOT1 flotillin 1
FOXN3 forkhead box N3
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1
GSPT1 G1 to S phase transition 1
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HMOX1 heme oxygenase 1
HNF4A hepatocyte nuclear factor 4, alpha
HSPA1L heat shock 70kDa protein 1-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT54 intraflagellar transport 54
IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker)
INSIG1 insulin induced gene 1
IPO8 importin 8
IRF1 interferon regulatory factor 1
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KCNS1 potassium voltage-gated channel, modifier subfamily S, member 1
KLF6 Kruppel-like factor 6
LST1 leukocyte specific transcript 1
MID1 midline 1
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MVP major vault protein
MYL5 myosin, light chain 5, regulatory
MYT1 myelin transcription factor 1
NCOR2 nuclear receptor corepressor 2
NF2 neurofibromin 2 (merlin)
NRSN2 neurensin 2
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
PALM paralemmin
PCDHA9 protocadherin alpha 9
PHKA2 phosphorylase kinase, alpha 2 (liver)
PPIL2 peptidylprolyl isomerase (cyclophilin)-like 2
PRKAR1B protein kinase, cAMP-dependent, regulatory, type I, beta
PTRF polymerase I and transcript release factor
PVRL3 poliovirus receptor-related 3
RAB30 RAB30, member RAS oncogene family
RAP1GAP RAP1 GTPase activating protein
RECQL5 RecQ protein-like 5
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RREB1 ras responsive element binding protein 1
SH2D4A SH2 domain containing 4A
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SPN sialophorin
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SYNJ2 synaptojanin 2
TBC1D17 TBC1 domain family, member 17
TLE4 transducin-like enhancer of split 4
TMC6 transmembrane channel-like 6
TTC9 tetratricopeptide repeat domain 9
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific
UBE2J1 ubiquitin-conjugating enzyme E2, J1
UBE3B ubiquitin protein ligase E3B
USP34 ubiquitin specific peptidase 34
XDH xanthine dehydrogenase
ZBTB17 zinc finger and BTB domain containing 17
ZC3H7B zinc finger CCCH-type containing 7B
ZCCHC24 zinc finger, CCHC domain containing 24
ZHX3 zinc fingers and homeoboxes 3
ZIM2 zinc finger, imprinted 2
ZNF117 zinc finger protein 117
ZNF350 zinc finger protein 350
ZNF571 zinc finger protein 571
ZNF609 zinc finger protein 609
ZSCAN12 zinc finger and SCAN domain containing 12

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ALAS1 5'-aminolevulinate synthase 1
ALKBH4 alkB, alkylation repair homolog 4 (E. coli)
AMT aminomethyltransferase
ANXA1 annexin A1
ASB7 ankyrin repeat and SOCS box containing 7
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
BCAS1 breast carcinoma amplified sequence 1
BCL9 B-cell CLL/lymphoma 9
BEX4 brain expressed, X-linked 4
BRD9 bromodomain containing 9
C16ORF59 chromosome 16 open reading frame 59
C1ORF159 chromosome 1 open reading frame 159
C3ORF52 chromosome 3 open reading frame 52
CCDC186 coiled-coil domain containing 186
CD82 CD82 molecule
CDC37 cell division cycle 37
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPT centromere protein T
CHST10 carbohydrate sulfotransferase 10
CISH cytokine inducible SH2-containing protein
CRELD1 cysteine-rich with EGF-like domains 1
CRYBG3 beta-gamma crystallin domain containing 3
DMTN dematin actin binding protein
DNAL4 dynein, axonemal, light chain 4
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DYSF dysferlin
ERCC4 excision repair cross-complementation group 4
FAN1 FANCD2/FANCI-associated nuclease 1
FBXL2 F-box and leucine-rich repeat protein 2
FER fer (fps/fes related) tyrosine kinase
FGGY FGGY carbohydrate kinase domain containing
FKBP10 FK506 binding protein 10, 65 kDa
FOXC1 forkhead box C1
GAN gigaxonin
HIST1H2BC histone cluster 1, H2bc
HIST1H4F histone cluster 1, H4f
HLA-J major histocompatibility complex, class I, J (pseudogene)
HPN hepsin
IPO13 importin 13
IRF6 interferon regulatory factor 6
JRKL JRK-like
KCNMB4 potassium channel subfamily M regulatory beta subunit 4
KCTD15 potassium channel tetramerization domain containing 15
KDM7A lysine (K)-specific demethylase 7A
KLF3 Kruppel-like factor 3 (basic)
L2HGDH L-2-hydroxyglutarate dehydrogenase
LHX1 LIM homeobox 1
LPXN leupaxin
LRRC20 leucine rich repeat containing 20
LRRC49 leucine rich repeat containing 49
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
LTBP2 latent transforming growth factor beta binding protein 2
LY6D lymphocyte antigen 6 complex, locus D
LZTR1 leucine-zipper-like transcription regulator 1
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MBNL3 muscleblind-like splicing regulator 3
MFAP2 microfibrillar-associated protein 2
MOSPD3 motile sperm domain containing 3
MRPL52 mitochondrial ribosomal protein L52
MUL1 mitochondrial E3 ubiquitin protein ligase 1
MYO1F myosin IF
NES nestin
NRGN neurogranin (protein kinase C substrate, RC3)
NT5DC3 5'-nucleotidase domain containing 3
PEX26 peroxisomal biogenesis factor 26
PLXNA3 plexin A3
PTDSS2 phosphatidylserine synthase 2
PTPRE protein tyrosine phosphatase, receptor type, E
RAB3A RAB3A, member RAS oncogene family
RRNAD1 ribosomal RNA adenine dimethylase domain containing 1
SAV1 salvador family WW domain containing protein 1
SCML2 sex comb on midleg-like 2 (Drosophila)
SOX12 SRY (sex determining region Y)-box 12
STAG3L4 stromal antigen 3-like 4 (pseudogene)
STRA6 stimulated by retinoic acid 6
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TCTA T-cell leukemia translocation altered
TFRC transferrin receptor
THNSL1 threonine synthase-like 1 (S. cerevisiae)
THRAP3 thyroid hormone receptor associated protein 3
TMEM120B transmembrane protein 120B
TMEM180 transmembrane protein 180
TPCN1 two pore segment channel 1
TPST2 tyrosylprotein sulfotransferase 2
TTC23 tetratricopeptide repeat domain 23
TTC30A tetratricopeptide repeat domain 30A
TUBA4A tubulin, alpha 4a
TUBG2 tubulin, gamma 2
UNC119 unc-119 homolog (C. elegans)
USB1 U6 snRNA biogenesis 1
XAB2 XPA binding protein 2
ZNF226 zinc finger protein 226
ZNF280D zinc finger protein 280D
ZNF286A zinc finger protein 286A
ZNF324 zinc finger protein 324
ZXDC ZXD family zinc finger C