harman-4408 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the harman-4408 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAN aggrecan
ACSM1 acyl-CoA synthetase medium-chain family member 1
ACVR1B activin A receptor, type IB
AHSP alpha hemoglobin stabilizing protein
AMELY amelogenin, Y-linked
APOH apolipoprotein H (beta-2-glycoprotein I)
ASMT acetylserotonin O-methyltransferase
BCL6 B-cell CLL/lymphoma 6
BEGAIN brain-enriched guanylate kinase-associated
C6 complement component 6
CAMK4 calcium/calmodulin-dependent protein kinase IV
CASP2 caspase 2, apoptosis-related cysteine peptidase
CDC14B cell division cycle 14B
CDK13 cyclin-dependent kinase 13
CDKN2A cyclin-dependent kinase inhibitor 2A
CFB complement factor B
CLSTN3 calsyntenin 3
CSF1 colony stimulating factor 1 (macrophage)
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTNS cystinosin, lysosomal cystine transporter
CTSZ cathepsin Z
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5
DAO D-amino-acid oxidase
DENND5B DENN/MADD domain containing 5B
DIO2 deiodinase, iodothyronine, type II
EDN1 endothelin 1
EHF ets homologous factor
ERAP1 endoplasmic reticulum aminopeptidase 1
FBN1 fibrillin 1
FGF18 fibroblast growth factor 18
FGL2 fibrinogen-like 2
FLJ22184
GLIPR1 GLI pathogenesis-related 1
GP2 glycoprotein 2 (zymogen granule membrane)
HIST1H3E histone cluster 1, H3e
HOXA10 homeobox A10
HOXA11 homeobox A11
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase
ICAM1 intercellular adhesion molecule 1
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
KCND3 potassium channel, voltage gated Shal related subfamily D, member 3
LENEP lens epithelial protein
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3
LIMS2 LIM and senescent cell antigen-like domains 2
LINC00341 long intergenic non-protein coding RNA 341
LOC100286895 cell division cycle 27 homolog pseudogene
LRRK1 leucine-rich repeat kinase 1
MAPRE3 microtubule-associated protein, RP/EB family, member 3
MAU2 MAU2 sister chromatid cohesion factor
MED25 mediator complex subunit 25
MVB12B multivesicular body subunit 12B
NCF4 neutrophil cytosolic factor 4, 40kDa
NEUROD6 neuronal differentiation 6
NF1 neurofibromin 1
NID1 nidogen 1
NRIP3 nuclear receptor interacting protein 3
OMG oligodendrocyte myelin glycoprotein
PAK7 p21 protein (Cdc42/Rac)-activated kinase 7
PDLIM4 PDZ and LIM domain 4
PGAP3 post-GPI attachment to proteins 3
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNMA3 paraneoplastic Ma antigen 3
PRB4 proline-rich protein BstNI subfamily 4
PTK2B protein tyrosine kinase 2 beta
PVRL1 poliovirus receptor-related 1 (herpesvirus entry mediator C)
RARB retinoic acid receptor, beta
RUNX1 runt-related transcription factor 1
SAA3P serum amyloid A3 pseudogene
SCN11A sodium channel, voltage gated, type XI alpha subunit
SELL selectin L
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SFTPB surfactant protein B
SFTPD surfactant protein D
SGCE sarcoglycan, epsilon
SH2D2A SH2 domain containing 2A
SIGLEC8 sialic acid binding Ig-like lectin 8
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
SLC12A4 solute carrier family 12 (potassium/chloride transporter), member 4
SLC19A3 solute carrier family 19 (thiamine transporter), member 3
SLC39A9 solute carrier family 39, member 9
SOAT2 sterol O-acyltransferase 2
SOX15 SRY (sex determining region Y)-box 15
SPN sialophorin
SPON1 spondin 1, extracellular matrix protein
STAC SH3 and cysteine rich domain
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1
TAOK2 TAO kinase 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGM2 transglutaminase 2
TNPO2 transportin 2
TTLL3 tubulin tyrosine ligase-like family member 3
TUBA3C tubulin, alpha 3c
URB1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae)
ZBTB17 zinc finger and BTB domain containing 17
ZKSCAN7 zinc finger with KRAB and SCAN domains 7
ZNF362 zinc finger protein 362
ZNF862 zinc finger protein 862

decreased expression

Symbol Name
A1CF APOBEC1 complementation factor
A2M alpha-2-macroglobulin
A4GALT alpha 1,4-galactosyltransferase
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
APLP1 amyloid beta (A4) precursor-like protein 1
ARID3B AT rich interactive domain 3B (BRIGHT-like)
C10ORF95 chromosome 10 open reading frame 95
C11ORF30 chromosome 11 open reading frame 30
C8ORF60 chromosome 8 open reading frame 60
CBR3 carbonyl reductase 3
CBX8 chromobox homolog 8
CCDC64 coiled-coil domain containing 64
CCP110 centriolar coiled coil protein 110kDa
CENPC centromere protein C
CFAP45 cilia and flagella associated protein 45
CLDN15 claudin 15
CRYGC crystallin, gamma C
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DYSF dysferlin
EMID1 EMI domain containing 1
ERCC2 excision repair cross-complementation group 2
ERN2 endoplasmic reticulum to nucleus signaling 2
F3 coagulation factor III (thromboplastin, tissue factor)
FAM53B family with sequence similarity 53, member B
FGF13 fibroblast growth factor 13
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GAMT guanidinoacetate N-methyltransferase
GK3P glycerol kinase 3 pseudogene
GLB1L galactosidase, beta 1-like
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GNG4 guanine nucleotide binding protein (G protein), gamma 4
GNG7 guanine nucleotide binding protein (G protein), gamma 7
HDAC7 histone deacetylase 7
HIST1H1D histone cluster 1, H1d
HIST1H2AJ histone cluster 1, H2aj
HMOX1 heme oxygenase 1
HOXC10 homeobox C10
HOXC8 homeobox C8
HYAL3 hyaluronoglucosaminidase 3
IFI27 interferon, alpha-inducible protein 27
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFT54 intraflagellar transport 54
IRF9 interferon regulatory factor 9
IRX4 iroquois homeobox 4
KCNK15 potassium channel, two pore domain subfamily K, member 15
KCTD7 potassium channel tetramerization domain containing 7
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KIAA0754 KIAA0754
KRT24 keratin 24, type I
LRP3 low density lipoprotein receptor-related protein 3
MED9 mediator complex subunit 9
MMP2 matrix metallopeptidase 2
MTA2 metastasis associated 1 family, member 2
MX2 MX dynamin-like GTPase 2
NOD1 nucleotide-binding oligomerization domain containing 1
NPY4R neuropeptide Y receptor Y4
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OSGIN1 oxidative stress induced growth inhibitor 1
PAIP2B poly(A) binding protein interacting protein 2B
PCDHB13 protocadherin beta 13
PDZRN3 PDZ domain containing ring finger 3
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLA2G3 phospholipase A2, group III
PLEKHO2 pleckstrin homology domain containing, family O member 2
PRSS22 protease, serine, 22
QPCTL glutaminyl-peptide cyclotransferase-like
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RNF126P1 ring finger protein 126 pseudogene 1
RORC RAR-related orphan receptor C
RPL13P5 ribosomal protein L13 pseudogene 5
SAA4 serum amyloid A4, constitutive
SCN1B sodium channel, voltage gated, type I beta subunit
SEC14L2 SEC14-like 2 (S. cerevisiae)
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae)
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6
SLC12A8 solute carrier family 12, member 8
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
STRA6 stimulated by retinoic acid 6
SYNC syncoilin, intermediate filament protein
TMEM57 transmembrane protein 57
TPSG1 tryptase gamma 1
TRIM36 tripartite motif containing 36
UBTD1 ubiquitin domain containing 1
USB1 U6 snRNA biogenesis 1
VLDLR very low density lipoprotein receptor
ZBTB44 zinc finger and BTB domain containing 44
ZDHHC14 zinc finger, DHHC-type containing 14
ZNF286A zinc finger protein 286A
ZNF552 zinc finger protein 552
ZNF665 zinc finger protein 665
ZNF76 zinc finger protein 76