hcc Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.|Tumors or cancer of the LIVER.|A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation. --2002|A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation. (Experimental Factor Ontology, EFO_0000182)
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Genes

733 genes co-occuring with the biological term hcc in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACE angiotensin I converting enzyme
ACOT8 acyl-CoA thioesterase 8
ACP5 acid phosphatase 5, tartrate resistant
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSL4 acyl-CoA synthetase long-chain family member 4
ACSS2 acyl-CoA synthetase short-chain family member 2
ADAM8 ADAM metallopeptidase domain 8
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADM adrenomedullin
ADORA3 adenosine A3 receptor
AFP alpha-fetoprotein
AGER advanced glycosylation end product-specific receptor
AGRN agrin
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ANGPT1 angiopoietin 1
ANGPT2 angiopoietin 2
ANXA2 annexin A2
ANXA7 annexin A7
APC adenomatous polyposis coli
APLN apelin
APLNR apelin receptor
ARG1 arginase 1
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39
ARID2 AT rich interactive domain 2 (ARID, RFX-like)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARNT aryl hydrocarbon receptor nuclear translocator
ASGR1 asialoglycoprotein receptor 1
ASL argininosuccinate lyase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATAD2 ATPase family, AAA domain containing 2
ATF2 activating transcription factor 2
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
AURKA aurora kinase A
AXIN1 axin 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
B3GAT1 beta-1,3-glucuronyltransferase 1
BAG1 BCL2-associated athanogene
BAG3 BCL2-associated athanogene 3
BAX BCL2-associated X protein
BCAR1 breast cancer anti-estrogen resistance 1
BCL2 B-cell CLL/lymphoma 2
BCL3 B-cell CLL/lymphoma 3
BCL6B B-cell CLL/lymphoma 6, member B
BHLHE40 basic helix-loop-helix family, member e40
BID BH3 interacting domain death agonist
BIN1 bridging integrator 1
BIRC5 baculoviral IAP repeat containing 5
BIRC7 baculoviral IAP repeat containing 7
BLMH bleomycin hydrolase
BMI1 BMI1 proto-oncogene, polycomb ring finger
BMX BMX non-receptor tyrosine kinase
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
BRMS1 breast cancer metastasis suppressor 1
BSG basigin (Ok blood group)
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
BVES blood vessel epicardial substance
CADM1 cell adhesion molecule 1
CADM2 cell adhesion molecule 2
CAPN2 calpain 2, (m/II) large subunit
CCL19 chemokine (C-C motif) ligand 19
CCL20 chemokine (C-C motif) ligand 20
CCL5 chemokine (C-C motif) ligand 5
CCNB1 cyclin B1
CCND1 cyclin D1
CCND3 cyclin D3
CCNG1 cyclin G1
CCNY cyclin Y
CCR1 chemokine (C-C motif) receptor 1
CCR2 chemokine (C-C motif) receptor 2
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CCR6 chemokine (C-C motif) receptor 6
CD151 CD151 molecule (Raph blood group)
CD163 CD163 molecule
CD24 CD24 molecule
CD274 CD274 molecule
CD276 CD276 molecule
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD4 CD4 molecule
CD44 CD44 molecule (Indian blood group)
CD82 CD82 molecule
CDC25A cell division cycle 25A
CDC25C cell division cycle 25C
CDC42 cell division cycle 42
CDCA7L cell division cycle associated 7-like
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH13 cadherin 13
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK14 cyclin-dependent kinase 14
CDK2 cyclin-dependent kinase 2
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN3 cyclin-dependent kinase inhibitor 3
CDO1 cysteine dioxygenase type 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CENPF centromere protein F, 350/400kDa
CENPH centromere protein H
CES1 carboxylesterase 1
CHEK1 checkpoint kinase 1
CHEK2 checkpoint kinase 2
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHKA choline kinase alpha
CHUK conserved helix-loop-helix ubiquitous kinase
CIDEC cell death-inducing DFFA-like effector c
CLDN10 claudin 10
CNDP1 carnosine dipeptidase 1 (metallopeptidase M20 family)
COL18A1 collagen, type XVIII, alpha 1
COPS3 COP9 signalosome subunit 3
COPS5 COP9 signalosome subunit 5
CPEB4 cytoplasmic polyadenylation element binding protein 4
CRHR2 corticotropin releasing hormone receptor 2
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CST3 cystatin C
CSTB cystatin B (stefin B)
CTBP1 C-terminal binding protein 1
CTCFL CCCTC-binding factor (zinc finger protein)-like
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTTN cortactin
CUX1 cut-like homeobox 1
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CXCR6 chemokine (C-X-C motif) receptor 6
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP2R1 cytochrome P450, family 2, subfamily R, polypeptide 1
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
CYP3A7 cytochrome P450, family 3, subfamily A, polypeptide 7
CYR61 cysteine-rich, angiogenic inducer, 61
DCX doublecortin
DDIT3 DNA-damage-inducible transcript 3
DEC1 deleted in esophageal cancer 1
DEPDC5 DEP domain containing 5
DHCR7 7-dehydrocholesterol reductase
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DKK4 dickkopf WNT signaling pathway inhibitor 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DLK1 delta-like 1 homolog (Drosophila)
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha
DPT dermatopontin
DUSP1 dual specificity phosphatase 1
DUSP21 dual specificity phosphatase 21
DUSP6 dual specificity phosphatase 6
DUT deoxyuridine triphosphatase
E2F1 E2F transcription factor 1
E2F3 E2F transcription factor 3
E2F5 E2F transcription factor 5, p130-binding
E2F8 E2F transcription factor 8
EGF epidermal growth factor
EGFL7 EGF-like-domain, multiple 7
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2
EIF3H eukaryotic translation initiation factor 3, subunit H
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EP300 E1A binding protein p300
EP400 E1A binding protein p400
EPAS1 endothelial PAS domain protein 1
EPCAM epithelial cell adhesion molecule
EPHA3 EPH receptor A3
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPOR erythropoietin receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB4 erb-b2 receptor tyrosine kinase 4
ERCC1 excision repair cross-complementation group 1
ESR1 estrogen receptor 1
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2 coagulation factor II (thrombin)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAT1 FAT atypical cadherin 1
FBXO5 F-box protein 5
FGF17 fibroblast growth factor 17
FGF18 fibroblast growth factor 18
FGF19 fibroblast growth factor 19
FGF2 fibroblast growth factor 2 (basic)
FGF8 fibroblast growth factor 8 (androgen-induced)
FGFR1 fibroblast growth factor receptor 1
FGFR4 fibroblast growth factor receptor 4
FGL1 fibrinogen-like 1
FGL2 fibrinogen-like 2
FKBP4 FK506 binding protein 4, 59kDa
FLT1 fms-related tyrosine kinase 1
FLT4 fms-related tyrosine kinase 4
FOS FBJ murine osteosarcoma viral oncogene homolog
FOXP3 forkhead box P3
FUT2 fucosyltransferase 2 (secretor status included)
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
FZD7 frizzled class receptor 7
GABARAPL1 GABA(A) receptor-associated protein like 1
GABPA GA binding protein transcription factor, alpha subunit 60kDa
GABRA3 gamma-aminobutyric acid (GABA) A receptor, alpha 3
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GC group-specific component (vitamin D binding protein)
GGCX gamma-glutamyl carboxylase
GGPS1 geranylgeranyl diphosphate synthase 1
GGT1 gamma-glutamyltransferase 1
GJB1 gap junction protein, beta 1, 32kDa
GLI1 GLI family zinc finger 1
GLI2 GLI family zinc finger 2
GNMT glycine N-methyltransferase
GOLM1 golgi membrane protein 1
GOLPH3 golgi phosphoprotein 3 (coat-protein)
GPBAR1 G protein-coupled bile acid receptor 1
GPC3 glypican 3
GPR87 G protein-coupled receptor 87
GRAMD4 GRAM domain containing 4
GRIK1 glutamate receptor, ionotropic, kainate 1
GSK3B glycogen synthase kinase 3 beta
GSTM1 glutathione S-transferase mu 1
GSTM2 glutathione S-transferase mu 2 (muscle)
GSTP1 glutathione S-transferase pi 1
GSTT1 glutathione S-transferase theta 1
GTF2B general transcription factor IIB
H19 H19, imprinted maternally expressed transcript (non-protein coding)
HAMP hepcidin antimicrobial peptide
HAVCR2 hepatitis A virus cellular receptor 2
HCCAT5 hepatocellular carcinoma associated transcript 5 (non-protein coding)
HDAC10 histone deacetylase 10
HDAC2 histone deacetylase 2
HDAC6 histone deacetylase 6
HEPACAM hepatic and glial cell adhesion molecule
HFE hemochromatosis
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-G major histocompatibility complex, class I, G
HMGA2 high mobility group AT-hook 2
HMGB1 high mobility group box 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPAB heterogeneous nuclear ribonucleoprotein A/B
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOXA9 homeobox A9
HP haptoglobin
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HPSE heparanase
HSF1 heat shock transcription factor 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA1B heat shock 70kDa protein 1B
HSPA4 heat shock 70kDa protein 4
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB2 heat shock 27kDa protein 2
HSPB6 heat shock protein, alpha-crystallin-related, B6
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
HTRA1 HtrA serine peptidase 1
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IFNA1 interferon, alpha 1
IFNAR1 interferon (alpha, beta and omega) receptor 1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IGDCC4 immunoglobulin superfamily, DCC subclass, member 4
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGF2R insulin-like growth factor 2 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL10 interleukin 10
IL12A interleukin 12A
IL15 interleukin 15
IL17A interleukin 17A
IL18 interleukin 18
IL1B interleukin 1, beta
IL23A interleukin 23, alpha subunit p19
IL23R interleukin 23 receptor
IL2RA interleukin 2 receptor, alpha
IL36A interleukin 36, alpha
IL6 interleukin 6
IL6R interleukin 6 receptor
ING1 inhibitor of growth family, member 1
ING4 inhibitor of growth family, member 4
INPPL1 inositol polyphosphate phosphatase-like 1
INSR insulin receptor
IQGAP1 IQ motif containing GTPase activating protein 1
IQGAP2 IQ motif containing GTPase activating protein 2
IRF3 interferon regulatory factor 3
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JAK1 Janus kinase 1
JAK2 Janus kinase 2
JST tumor suppressor gene JST
JUN jun proto-oncogene
KAT2B K(lysine) acetyltransferase 2B
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KDR kinase insert domain receptor
KIAA0101 KIAA0101
KIAA1524 KIAA1524
KIF1B kinesin family member 1B
KIF3B kinesin family member 3B
KISS1 KiSS-1 metastasis-suppressor
KISS1R KISS1 receptor
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KLF6 Kruppel-like factor 6
KRT18 keratin 18, type I
KRT19 keratin 19, type I
L1CAM L1 cell adhesion molecule
LAG3 lymphocyte-activation gene 3
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LDHB lactate dehydrogenase B
LECT2 leukocyte cell-derived chemotaxin 2
LEP leptin
LEPR leptin receptor
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS4 lectin, galactoside-binding, soluble, 4
LIN28A lin-28 homolog A (C. elegans)
LLGL1 lethal giant larvae homolog 1 (Drosophila)
LMCD1 LIM and cysteine-rich domains 1
LMNB1 lamin B1
LRP1 low density lipoprotein receptor-related protein 1
LRRC1 leucine rich repeat containing 1
MACC1 metastasis associated in colon cancer 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAGED4B melanoma antigen family D4B
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK7 mitogen-activated protein kinase 7
MAPK8 mitogen-activated protein kinase 8
MAPRE1 microtubule-associated protein, RP/EB family, member 1
MARVELD1 MARVEL domain containing 1
MASP2 mannan-binding lectin serine peptidase 2
MAT1A methionine adenosyltransferase I, alpha
MBL2 mannose-binding lectin (protein C) 2, soluble
MCL1 myeloid cell leukemia 1
MCM7 minichromosome maintenance complex component 7
MDK midkine (neurite growth-promoting factor 2)
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MET MET proto-oncogene, receptor tyrosine kinase
MFN2 mitofusin 2
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MICA MHC class I polypeptide-related sequence A
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MIR106B microRNA 106b
MIR10A microRNA 10a
MIR10B microRNA 10b
MIR122 microRNA 122
MIR1231 microRNA 1231
MIR124-1 microRNA 124-1
MIR125B1 microRNA 125b-1
MIR126 microRNA 126
MIR129-2 microRNA 129-2
MIR132 microRNA 132
MIR140 microRNA 140
MIR141 microRNA 141
MIR142 microRNA 142
MIR146A microRNA 146a
MIR152 microRNA 152
MIR155 microRNA 155
MIR15B microRNA 15b
MIR17 microRNA 17
MIR181A2 microRNA 181a-2
MIR181B1 microRNA 181b-1
MIR182 microRNA 182
MIR184 microRNA 184
MIR185 microRNA 185
MIR191 microRNA 191
MIR194-1 microRNA 194-1
MIR195 microRNA 195
MIR196A2 microRNA 196a-2
MIR197 microRNA 197
MIR199A2 microRNA 199a-2
MIR199B microRNA 199b
MIR200A microRNA 200a
MIR205 microRNA 205
MIR206 microRNA 206
MIR21 microRNA 21
MIR210 microRNA 210
MIR212 microRNA 212
MIR214 microRNA 214
MIR217 microRNA 217
MIR221 microRNA 221
MIR222 microRNA 222
MIR223 microRNA 223
MIR224 microRNA 224
MIR24-1 microRNA 24-1
MIR26A1 microRNA 26a-1
MIR26B microRNA 26b
MIR301A microRNA 301a
MIR30A microRNA 30a
MIR34A microRNA 34a
MIR34B microRNA 34b
MIR34C microRNA 34c
MIR370 microRNA 370
MIR371A microRNA 371a
MIR372 microRNA 372
MIR373 microRNA 373
MIR375 microRNA 375
MIR432 microRNA 432
MIR499A microRNA 499a
MIR500A microRNA 500a
MIR519D microRNA 519d
MIR520G microRNA 520g
MIR636 microRNA 636
MIR637 microRNA 637
MIR650 microRNA 650
MIR675 microRNA 675
MIR9-1 microRNA 9-1
MIR920 microRNA 920
MIR99A microRNA 99a
MIRLET7A1 microRNA let-7a-1
MIRLET7G microRNA let-7g
MKI67 marker of proliferation Ki-67
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MMP16 matrix metallopeptidase 16 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MPO myeloperoxidase
MPZL1 myelin protein zero-like 1
MSRA methionine sulfoxide reductase A
MST1 macrophage stimulating 1
MTA1 metastasis associated 1
MTDH metadherin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MUC2 mucin 2, oligomeric mucus/gel-forming
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYDGF myeloid-derived growth factor
NANOG Nanog homeobox
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)
NCK1 NCK adaptor protein 1
NCOA3 nuclear receptor coactivator 3
NCOA5 nuclear receptor coactivator 5
NDRG1 N-myc downstream regulated 1
NDRG2 NDRG family member 2
NELFE negative elongation factor complex member E
NET1 neuroepithelial cell transforming 1
NEWENTRY Record to support submission of GeneRIFs for a gene not in Gene (human; man).
NF2 neurofibromin 2 (merlin)
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NGF nerve growth factor (beta polypeptide)
NGFR nerve growth factor receptor
NLRP3 NLR family, pyrin domain containing 3
NODAL nodal growth differentiation factor
NOTCH1 notch 1
NOTCH3 notch 3
NOTCH4 notch 4
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPRL2 nitrogen permease regulator-like 2 (S. cerevisiae)
NR1I2 nuclear receptor subfamily 1, group I, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRSN2 neurensin 2
NTN1 netrin 1
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
NTS neurotensin
OGG1 8-oxoguanine DNA glycosylase
OPA1 optic atrophy 1 (autosomal dominant)
OPRD1 opioid receptor, delta 1
OTUD7A OTU deubiquitinase 7A
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
PADI4 peptidyl arginine deiminase, type IV
PAK4 p21 protein (Cdc42/Rac)-activated kinase 4
PARK7 parkinson protein 7
PCBP1 poly(rC) binding protein 1
PDCD1 programmed cell death 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDCD5 programmed cell death 5
PDGFB platelet-derived growth factor beta polypeptide
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PEG10 paternally expressed 10
PFKP phosphofructokinase, platelet
PGF placental growth factor
PIGR polymeric immunoglobulin receptor
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIM3 Pim-3 proto-oncogene, serine/threonine kinase
PIWIL1 piwi-like RNA-mediated gene silencing 1
PKM pyruvate kinase, muscle
PLAC1 placenta-specific 1
PLAU plasminogen activator, urokinase
PLK1 polo-like kinase 1
PLK4 polo-like kinase 4
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PML promyelocytic leukemia
PON1 paraoxonase 1
POU5F1 POU class 5 homeobox 1
PPAPDC1B phosphatidic acid phosphatase type 2 domain containing 1B
PPARG peroxisome proliferator-activated receptor gamma
PPIA peptidylprolyl isomerase A (cyclophilin A)
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP6C protein phosphatase 6, catalytic subunit
PRDM2 PR domain containing 2, with ZNF domain
PRDX1 peroxiredoxin 1
PRDX2 peroxiredoxin 2
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit
PRKCB protein kinase C, beta
PRKCI protein kinase C, iota
PROCR protein C receptor, endothelial
PROK2 prokineticin 2
PROM1 prominin 1
PROX1 prospero homeobox 1
PRPF4B pre-mRNA processing factor 4B
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTAFR platelet-activating factor receptor
PTCH1 patched 1
PTEN phosphatase and tensin homolog
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa
PTGES prostaglandin E synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTK2B protein tyrosine kinase 2 beta
PTOV1 prostate tumor overexpressed 1
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRO protein tyrosine phosphatase, receptor type, O
PTTG1 pituitary tumor-transforming 1
PXN paxillin
RAB23 RAB23, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RACGAP1 Rac GTPase activating protein 1
RARB retinoic acid receptor, beta
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RB1 retinoblastoma 1
RBP2 retinol binding protein 2, cellular
RBP5 retinol binding protein 5, cellular
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RECK reversion-inducing-cysteine-rich protein with kazal motifs
RHOA ras homolog family member A
RHOC ras homolog family member C
RIT1 Ras-like without CAAX 1
RLN2 relaxin 2
ROR2 receptor tyrosine kinase-like orphan receptor 2
RORA RAR-related orphan receptor A
RPL39L ribosomal protein L39-like
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RTL1 retrotransposon-like 1
RTN4 reticulon 4
RUNX3 runt-related transcription factor 3
S100A4 S100 calcium binding protein A4
S100P S100 calcium binding protein P
SAMD9L sterile alpha motif domain containing 9-like
SATB1 SATB homeobox 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCYL1 SCY1-like 1 (S. cerevisiae)
SDC1 syndecan 1
SEC62 SEC62 homolog (S. cerevisiae)
SELENBP1 selenium binding protein 1
SEPP1 selenoprotein P, plasma, 1
SEPT2 septin 2
SEPT4 septin 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SHH sonic hedgehog
SIAH1 siah E3 ubiquitin protein ligase 1
SIRT1 sirtuin 1
SIRT3 sirtuin 3
SIRT6 sirtuin 6
SIX1 SIX homeobox 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC16A4 solute carrier family 16, member 4
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SLIT2 slit homolog 2 (Drosophila)
SMAD3 SMAD family member 3
SMAD4 SMAD family member 4
SMAD7 SMAD family member 7
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase
SMO smoothened, frizzled class receptor
SNAI1 snail family zinc finger 1
SNW1 SNW domain containing 1
SOCS1 suppressor of cytokine signaling 1
SOD2 superoxide dismutase 2, mitochondrial
SOX17 SRY (sex determining region Y)-box 17
SOX2 SRY (sex determining region Y)-box 2
SOX7 SRY (sex determining region Y)-box 7
SP1 Sp1 transcription factor
SPAG9 sperm associated antigen 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
SPRED1 sprouty-related, EVH1 domain containing 1
SPRED2 sprouty-related, EVH1 domain containing 2
SPTBN1 spectrin, beta, non-erythrocytic 1
SRF serum response factor (c-fos serum response element-binding transcription factor)
SRY sex determining region Y
SSTR2 somatostatin receptor 2
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT4 signal transducer and activator of transcription 4
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
SULT2B1 sulfotransferase family, cytosolic, 2B, member 1
TAGLN2 transgelin 2
TARDBP TAR DNA binding protein
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCP1 t-complex 1
TERT telomerase reverse transcriptase
TET1 tet methylcytosine dioxygenase 1
TFCP2 transcription factor CP2
TFPI2 tissue factor pathway inhibitor 2
TFR2 transferrin receptor 2
TFRC transferrin receptor
TGFA transforming growth factor, alpha
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
THAP11 THAP domain containing 11
THBD thrombomodulin
THY1 Thy-1 cell surface antigen
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIAM1 T-cell lymphoma invasion and metastasis 1
TIAM2 T-cell lymphoma invasion and metastasis 2
TIMP2 TIMP metallopeptidase inhibitor 2
TIPE2 TNF alpha induced protein 8 like 2
TIPRL TOR signaling pathway regulator
TLR2 toll-like receptor 2
TLR4 toll-like receptor 4
TMPRSS4 transmembrane protease, serine 4
TMSB10 thymosin beta 10
TMSB4X thymosin beta 4, X-linked
TNF tumor necrosis factor
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNS2 tensin 2
TP53 tumor protein p53
TP53BP2 tumor protein p53 binding protein 2
TP73 tumor protein p73
TPM3 tropomyosin 3
TREM1 triggering receptor expressed on myeloid cells 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
TRPV2 transient receptor potential cation channel, subfamily V, member 2
TRRAP transformation/transcription domain-associated protein
TSG101 tumor susceptibility 101
TSGA10 testis specific, 10
TSPAN1 tetraspanin 1
TSPY1 testis specific protein, Y-linked 1
TSPYL2 TSPY-like 2
TWIST1 twist family bHLH transcription factor 1
TXLNA taxilin alpha
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum)
UBD ubiquitin D
UBE2L3 ubiquitin-conjugating enzyme E2L 3
UCHL5 ubiquitin carboxyl-terminal hydrolase L5
ULBP1 UL16 binding protein 1
UNC5C unc-5 homolog C (C. elegans)
USF1 upstream transcription factor 1
USF2 upstream transcription factor 2, c-fos interacting
USP9X ubiquitin specific peptidase 9, X-linked
UTS2R urotensin 2 receptor
VAC14 Vac14 homolog (S. cerevisiae)
VASH1 vasohibin 1
VCAN versican
VCP valosin containing protein
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
VEGFC vascular endothelial growth factor C
VIL1 villin 1
VIM vimentin
VMP1 vacuole membrane protein 1
VPS37A vacuolar protein sorting 37 homolog A (S. cerevisiae)
VWF von Willebrand factor
WASF2 WAS protein family, member 2
WIF1 WNT inhibitory factor 1
WNT1 wingless-type MMTV integration site family, member 1
WNT3 wingless-type MMTV integration site family, member 3
WNT5A wingless-type MMTV integration site family, member 5A
WT1 Wilms tumor 1
XPC xeroderma pigmentosum, complementation group C
XPO4 exportin 4
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1
XRCC3 X-ray repair complementing defective repair in Chinese hamster cells 3
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
YAP1 Yes-associated protein 1
YBX1 Y box binding protein 1
YBX3 Y box binding protein 3
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YY1 YY1 transcription factor
ZBTB20 zinc finger and BTB domain containing 20
ZBTB7A zinc finger and BTB domain containing 7A
ZDHHC2 zinc finger, DHHC-type containing 2
ZG16 zymogen granule protein 16
ZIC1 Zic family member 1
ZNF592 zinc finger protein 592