hdac4 Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description histone deacetylase 4|Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9759)
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Genes

51 genes co-occuring with the biological term hdac4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ATF2 activating transcription factor 2
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
CAMK2D calcium/calmodulin-dependent protein kinase II delta
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
EGR1 early growth response 1
EP300 E1A binding protein p300
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
HDAC1 histone deacetylase 1
HDAC2 histone deacetylase 2
HDAC3 histone deacetylase 3
HDAC4 histone deacetylase 4
HDAC5 histone deacetylase 5
HDAC7 histone deacetylase 7
HDAC8 histone deacetylase 8
HDAC9 histone deacetylase 9
HHIP hedgehog interacting protein
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
IFRD1 interferon-related developmental regulator 1
IL24 interleukin 24
IL5 interleukin 5
KAT2B K(lysine) acetyltransferase 2B
KDM5B lysine (K)-specific demethylase 5B
MAPK8 mitogen-activated protein kinase 8
MEF2A myocyte enhancer factor 2A
MIR1-2 microRNA 1-2
MIR200A microRNA 200a
MIR206 microRNA 206
MIR22 microRNA 22
MMP13 matrix metallopeptidase 13
NCOR2 nuclear receptor corepressor 2
NCR3 natural cytotoxicity triggering receptor 3
NFE2L2 nuclear factor, erythroid 2-like 2
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PTGES prostaglandin E synthase
PTH parathyroid hormone
RANBP2 RAN binding protein 2
RARB retinoic acid receptor, beta
RCOR1 REST corepressor 1
RGS2 regulator of G-protein signaling 2
RUNX2 runt-related transcription factor 2
SP1 Sp1 transcription factor
TGFB1 transforming growth factor, beta 1
THBD thrombomodulin
TP53 tumor protein p53
TP53BP1 tumor protein p53 binding protein 1
VEGFA vascular endothelial growth factor A
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YY1 YY1 transcription factor
ZBTB16 zinc finger and BTB domain containing 16