heart failure Gene Set

Dataset GAD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description disease cluster belonging to disease group cardiovascular (Genetic Association Database)
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221 genes associated with the disease heart failure in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

Symbol Name
AATK apoptosis-associated tyrosine kinase
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACE angiotensin I converting enzyme
ACO1 aconitase 1, soluble
ADAM19 ADAM metallopeptidase domain 19
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12
ADCY9 adenylate cyclase 9
ADGRE1 adhesion G protein-coupled receptor E1
ADRA2C adrenoceptor alpha 2C
ADRB1 adrenoceptor beta 1
ADRB2 adrenoceptor beta 2, surface
ADRBK1 adrenergic, beta, receptor kinase 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AHCYL2 adenosylhomocysteinase-like 2
AK5 adenylate kinase 5
AKAP7 A kinase (PRKA) anchor protein 7
AMPD1 adenosine monophosphate deaminase 1
ANK2 ankyrin 2, neuronal
ANKRD11 ankyrin repeat domain 11
ANO4 anoctamin 4
ANPEP alanyl (membrane) aminopeptidase
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGAP15 Rho GTPase activating protein 15
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ARSG arylsulfatase G
ARVCF armadillo repeat gene deleted in velocardiofacial syndrome
ATE1 arginyltransferase 1
ATXN1 ataxin 1
BIVM basic, immunoglobulin-like variable motif containing
BMP6 bone morphogenetic protein 6
BMPER BMP binding endothelial regulator
C1QTNF6 C1q and tumor necrosis factor related protein 6
C7 complement component 7
C9ORF171 chromosome 9 open reading frame 171
C9ORF66 chromosome 9 open reading frame 66
CABIN1 calcineurin binding protein 1
CAMTA1 calmodulin binding transcription activator 1
CCDC108 coiled-coil domain containing 108
CCNJL cyclin J-like
CD14 CD14 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CDH10 cadherin 10, type 2 (T2-cadherin)
CDH13 cadherin 13
CDH15 cadherin 15, type 1, M-cadherin (myotubule)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK10 cyclin-dependent kinase 10
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1
CELF2 CUGBP, Elav-like family member 2
CFAP61 cilia and flagella associated protein 61
CHRNA6 cholinergic receptor, nicotinic, alpha 6 (neuronal)
CLU clusterin
CMTM7 CKLF-like MARVEL transmembrane domain containing 7
CNGB3 cyclic nucleotide gated channel beta 3
CNOT2 CCR4-NOT transcription complex, subunit 2
CNTN5 contactin 5
CNTNAP2 contactin associated protein-like 2
CPM carboxypeptidase M
CPNE7 copine VII
CRNKL1 crooked neck pre-mRNA splicing factor 1
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
DBN1 drebrin 1
DCBLD1 discoidin, CUB and LCCL domain containing 1
DCLK2 doublecortin-like kinase 2
DLG2 discs, large homolog 2 (Drosophila)
DLGAP1 discs, large (Drosophila) homolog-associated protein 1
DOCK2 dedicator of cytokinesis 2
DOCK8 dedicator of cytokinesis 8
DOCK9 dedicator of cytokinesis 9
E2F3 E2F transcription factor 3
EDN1 endothelin 1
EGFLAM EGF-like, fibronectin type III and laminin G domains
ERC2 ELKS/RAB6-interacting/CAST family member 2
ERICH3 glutamate-rich 3
ETAA1 Ewing tumor-associated antigen 1
FAM135B family with sequence similarity 135, member B
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial
FBXL7 F-box and leucine-rich repeat protein 7
FGF14 fibroblast growth factor 14
FHIT fragile histidine triad
FOCAD focadhesin
FOXN3 forkhead box N3
FRMD6 FERM domain containing 6
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GAP43 growth associated protein 43
GAS8 growth arrest-specific 8
GLI3 GLI family zinc finger 3
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
GPATCH2 G patch domain containing 2
GPM6A glycoprotein M6A
GPR137C G protein-coupled receptor 137C
GPR39 G protein-coupled receptor 39
GRID2 glutamate receptor, ionotropic, delta 2
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B
GRK5 G protein-coupled receptor kinase 5
HCFC2 host cell factor C2
HCP5 HLA complex P5 (non-protein coding)
HIBADH 3-hydroxyisobutyrate dehydrogenase
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4
IFNG interferon, gamma
IFRD1 interferon-related developmental regulator 1
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IL10 interleukin 10
IL6 interleukin 6
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
IQSEC3 IQ motif and Sec7 domain 3
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JADE2 jade family PHD finger 2
KCNE1 potassium channel, voltage gated subfamily E regulatory beta subunit 1
KCNQ3 potassium channel, voltage gated KQT-like subfamily Q, member 3
KCNU1 potassium channel, subfamily U, member 1
KDM4C lysine (K)-specific demethylase 4C
KIAA1217 KIAA1217
KIAA1468 KIAA1468
KIRREL3 kin of IRRE like 3 (Drosophila)
KRT74 keratin 74, type II
LAMC3 laminin, gamma 3
LARGE like-glycosyltransferase
LEP leptin
LEPR leptin receptor
LIFR leukemia inhibitory factor receptor alpha
LMNTD1 lamin tail domain containing 1
LRIG3 leucine-rich repeats and immunoglobulin-like domains 3
LRRC69 leucine rich repeat containing 69
LYST lysosomal trafficking regulator
MALRD1 MAM and LDL receptor class A domain containing 1
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
MECOM MDS1 and EVI1 complex locus
MMP2 matrix metallopeptidase 2
MOB3B MOB kinase activator 3B
MPPED2 metallophosphoesterase domain containing 2
MTPN myotrophin
MTUS2 microtubule associated tumor suppressor candidate 2
MUC16 mucin 16, cell surface associated
MYO16 myosin XVI
NALCN sodium leak channel, non selective
NCOA7 nuclear receptor coactivator 7
NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NIPAL4 NIPA-like domain containing 4
NLRP4 NLR family, pyrin domain containing 4
NLRP9 NLR family, pyrin domain containing 9
NMNAT2 nicotinamide nucleotide adenylyltransferase 2
NOS3 nitric oxide synthase 3 (endothelial cell)
NPR3 natriuretic peptide receptor 3
NTM neurotrimin
NVL nuclear VCP-like
NXPH2 neurexophilin 2
OSM oncostatin M
OTUD7A OTU deubiquitinase 7A
PAPPA pregnancy-associated plasma protein A, pappalysin 1
PARVA parvin, alpha
PIGN phosphatidylinositol glycan anchor biosynthesis, class N
PLCL2 phospholipase C-like 2
PLXDC2 plexin domain containing 2
POMC proopiomelanocortin
POU2AF1 POU class 2 associating factor 1
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
PPP1R9B protein phosphatase 1, regulatory subunit 9B
PPP2R2B protein phosphatase 2, regulatory subunit B, beta
PRDM7 PR domain containing 7
PTHLH parathyroid hormone-like hormone
PTPRD protein tyrosine phosphatase, receptor type, D
RANBP17 RAN binding protein 17
RASGEF1C RasGEF domain family, member 1C
RCL1 RNA terminal phosphate cyclase-like 1
RGS5 regulator of G-protein signaling 5
RHBDL1 rhomboid, veinlet-like 1 (Drosophila)
ROR1 receptor tyrosine kinase-like orphan receptor 1
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCIN scinderin
SDF2L1 stromal cell-derived factor 2-like 1
SDK1 sidekick cell adhesion molecule 1
SERAC1 serine active site containing 1
SERPINE3 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3
SFSWAP splicing factor, suppressor of white-apricot family
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SHC4 SHC (Src homology 2 domain containing) family, member 4
SIPA1L3 signal-induced proliferation-associated 1 like 3
SLC35F1 solute carrier family 35, member F1
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19
SMEK1 SMEK homolog 1, suppressor of mek1 (Dictyostelium)
SMYD3 SET and MYND domain containing 3
SPEN spen family transcriptional repressor
SRFBP1 serum response factor binding protein 1
ST8SIA2 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
STAMBPL1 STAM binding protein-like 1
STK32A serine/threonine kinase 32A
STRN3 striatin, calmodulin binding protein 3
STXBP5 syntaxin binding protein 5 (tomosyn)
STXBP6 syntaxin binding protein 6 (amisyn)
SULF2 sulfatase 2
SYCP1 synaptonemal complex protein 1
SYNJ2 synaptojanin 2
TBC1D5 TBC1 domain family, member 5
TENM2 teneurin transmembrane protein 2
TGFB1 transforming growth factor, beta 1
TGFBR3 transforming growth factor, beta receptor III
TNF tumor necrosis factor
TNS1 tensin 1
TRAPPC11 trafficking protein particle complex 11
TRAPPC9 trafficking protein particle complex 9
TRIM33 tripartite motif containing 33
TTC6 tetratricopeptide repeat domain 6
TUBGCP3 tubulin, gamma complex associated protein 3
UGT1A1 UDP glucuronosyltransferase 1 family, polypeptide A1
UPB1 ureidopropionase, beta
USP22 ubiquitin specific peptidase 22
USP3 ubiquitin specific peptidase 3
VEGFA vascular endothelial growth factor A
VKORC1 vitamin K epoxide reductase complex, subunit 1
VSTM1 V-set and transmembrane domain containing 1
VWA3B von Willebrand factor A domain containing 3B