heart looping Gene Set
Dataset
GO Biological Process Annotations 2025
Category
structural or functional annotations
Type
biological process
Description
The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation. (Gene Ontology , GO_0001947 )
External Link
http://amigo.geneontology.org/amigo/term/GO:0001947
Similar Terms
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Genes
39 genes participating in the heart looping biological process from the curated GO Biological Process Annotations 2025 dataset.
Symbol
Name
AHI1
Abelson helper integration site 1
APLNR
apelin receptor
BBS5
Bardet-Biedl syndrome 5
BBS7
Bardet-Biedl syndrome 7
CCDC39
coiled-coil domain containing 39
CCDC40
coiled-coil domain containing 40
DLL1
delta-like 1 (Drosophila)
DNAAF1
dynein, axonemal, assembly factor 1
DNAAF19
dynein axonemal assembly factor 19
DVL1
dishevelled segment polarity protein 1
DVL2
dishevelled segment polarity protein 2
ENG
endoglin
FOLR2
folate receptor 2 (fetal)
FOXH1
forkhead box H1
FOXN4
forkhead box N4
GATA4
GATA binding protein 4
HAND1
heart and neural crest derivatives expressed 1
IHH
indian hedgehog
MEF2C
myocyte enhancer factor 2C
MESP1
mesoderm posterior basic helix-loop-helix transcription factor 1
MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
MKKS
McKusick-Kaufman syndrome
NDRG4
NDRG family member 4
NKX2-5
NK2 homeobox 5
NOTCH1
notch 1
NPHP3
nephronophthisis 3 (adolescent)
PRKD2
protein kinase D2
SETDB2
SET domain, bifurcated 2
SHH
sonic hedgehog
SMOX
spermine oxidase
SOX17
SRY (sex determining region Y)-box 17
SOX18
SRY (sex determining region Y)-box 18
SRF
serum response factor (c-fos serum response element-binding transcription factor)
STIL
SCL/TAL1 interrupting locus
TBX2
T-box 2
TBX20
T-box 20
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
VANGL2
VANGL planar cell polarity protein 2
ZIC3
Zic family member 3
