hecogenin-2716 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the hecogenin-2716 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AFF4 AF4/FMR2 family, member 4
AHCYL2 adenosylhomocysteinase-like 2
AIM1L absent in melanoma 1-like
ARID4B AT rich interactive domain 4B (RBP1-like)
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL6 B-cell CLL/lymphoma 6
BMP7 bone morphogenetic protein 7
C1QTNF1 C1q and tumor necrosis factor related protein 1
CA5A carbonic anhydrase VA, mitochondrial
CACNA1I calcium channel, voltage-dependent, T type, alpha 1I subunit
CD180 CD180 molecule
CD1E CD1e molecule
CD200 CD200 molecule
CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2
CDCP1 CUB domain containing protein 1
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2
COL14A1 collagen, type XIV, alpha 1
CRY2 cryptochrome circadian clock 2
CXCR3 chemokine (C-X-C motif) receptor 3
CYTH1 cytohesin 1
DBT dihydrolipoamide branched chain transacylase E2
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
DNAJC4 DnaJ (Hsp40) homolog, subfamily C, member 4
DNASE2 deoxyribonuclease II, lysosomal
DOK5 docking protein 5
DSG2 desmoglein 2
DUSP9 dual specificity phosphatase 9
EML3 echinoderm microtubule associated protein like 3
EXTL3 exostosin-like glycosyltransferase 3
F11R F11 receptor
FAM169A family with sequence similarity 169, member A
FGFR1 fibroblast growth factor receptor 1
FLRT1 fibronectin leucine rich transmembrane protein 1
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)
GCM1 glial cells missing homolog 1 (Drosophila)
GLI3 GLI family zinc finger 3
GPRC5D G protein-coupled receptor, class C, group 5, member D
GSK3A glycogen synthase kinase 3 alpha
HIST1H2BC histone cluster 1, H2bc
HSD17B14 hydroxysteroid (17-beta) dehydrogenase 14
HSPA2 heat shock 70kDa protein 2
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IFNB1 interferon, beta 1, fibroblast
ITGA6 integrin, alpha 6
KCNMB2 potassium channel subfamily M regulatory beta subunit 2
KIAA0226L KIAA0226-like
KRT18 keratin 18, type I
LIG3 ligase III, DNA, ATP-dependent
LPPR2 lipid phosphate phosphatase-related protein type 2
MOG myelin oligodendrocyte glycoprotein
MPP3 membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
MXD4 MAX dimerization protein 4
MYH10 myosin, heavy chain 10, non-muscle
NF1 neurofibromin 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRDE2 NRDE-2, necessary for RNA interference, domain containing
NRG2 neuregulin 2
OR12D2 olfactory receptor, family 12, subfamily D, member 2 (gene/pseudogene)
PADI1 peptidyl arginine deiminase, type I
PAPPA2 pappalysin 2
PEX16 peroxisomal biogenesis factor 16
PHF14 PHD finger protein 14
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta
PRKY protein kinase, Y-linked, pseudogene
PRMT8 protein arginine methyltransferase 8
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRF protein tyrosine phosphatase, receptor type, F
RANBP1 RAN binding protein 1
RAPGEFL1 Rap guanine nucleotide exchange factor (GEF)-like 1
RFX3 regulatory factor X, 3 (influences HLA class II expression)
RPS2P45 ribosomal protein S2 pseudogene 45
SEMA6B sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
SEMA6D sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
SLC12A3 solute carrier family 12 (sodium/chloride transporter), member 3
SLC24A2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
SLC25A16 solute carrier family 25 (mitochondrial carrier), member 16
SOX13 SRY (sex determining region Y)-box 13
SPHK1 sphingosine kinase 1
SSTR4 somatostatin receptor 4
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SYNDIG1 synapse differentiation inducing 1
SYNGR3 synaptogyrin 3
TAAR3 trace amine associated receptor 3 (gene/pseudogene)
TBX5 T-box 5
TBXA2R thromboxane A2 receptor
TLN2 talin 2
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM63A transmembrane protein 63A
TRBC1 T cell receptor beta constant 1
TSC22D2 TSC22 domain family, member 2
VEGFA vascular endothelial growth factor A
ZNF500 zinc finger protein 500
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ADM adrenomedullin
ARMCX4 armadillo repeat containing, X-linked 4
ATAD2B ATPase family, AAA domain containing 2B
BMP15 bone morphogenetic protein 15
BNC2 basonuclin 2
BPHL biphenyl hydrolase-like (serine hydrolase)
CASS4 Cas scaffolding protein family member 4
CCDC57 coiled-coil domain containing 57
CCRL2 chemokine (C-C motif) receptor-like 2
CD70 CD70 molecule
CD82 CD82 molecule
CHPF chondroitin polymerizing factor
DDN dendrin
DSPP dentin sialophosphoprotein
EIF5A2 eukaryotic translation initiation factor 5A2
FAM102A family with sequence similarity 102, member A
FGF23 fibroblast growth factor 23
FLT4 fms-related tyrosine kinase 4
GNL3LP1 guanine nucleotide binding protein-like 3 (nucleolar)-like pseudogene 1
GPC3 glypican 3
GPR75 G protein-coupled receptor 75
GPRC5C G protein-coupled receptor, class C, group 5, member C
GRIP2 glutamate receptor interacting protein 2
HIST1H2AI histone cluster 1, H2ai
HIST1H2AM histone cluster 1, H2am
HIST1H3B histone cluster 1, H3b
HIST1H3H histone cluster 1, H3h
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
ICK intestinal cell (MAK-like) kinase
IFNA14 interferon, alpha 14
IFT140 intraflagellar transport 140
IL2 interleukin 2
IPO8 importin 8
IRS1 insulin receptor substrate 1
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KLK7 kallikrein-related peptidase 7
KLRG1 killer cell lectin-like receptor subfamily G, member 1
LINC00597 long intergenic non-protein coding RNA 597
LNPEP leucyl/cystinyl aminopeptidase
LPAR4 lysophosphatidic acid receptor 4
LTBP3 latent transforming growth factor beta binding protein 3
MAB21L1 mab-21-like 1 (C. elegans)
MAPK8 mitogen-activated protein kinase 8
MBL1P mannose-binding lectin (protein A) 1, pseudogene
MEGF8 multiple EGF-like-domains 8
MEP1B meprin A, beta
METTL16 methyltransferase like 16
MLPH melanophilin
MTG1 mitochondrial ribosome-associated GTPase 1
MTSS1L metastasis suppressor 1-like
NAG18 NAG18 mRNA
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
PCYOX1 prenylcysteine oxidase 1
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime
PEX13 peroxisomal biogenesis factor 13
PKD2L2 polycystic kidney disease 2-like 2
POM121 POM121 transmembrane nucleoporin
POU5F1B POU class 5 homeobox 1B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDM1 PR domain containing 1, with ZNF domain
PRF1 perforin 1 (pore forming protein)
PRSS53 protease, serine, 53
RANBP17 RAN binding protein 17
RCAN3 RCAN family member 3
REM1 RAS (RAD and GEM)-like GTP-binding 1
RNF126P1 ring finger protein 126 pseudogene 1
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RWDD2A RWD domain containing 2A
SCGB2A2 secretoglobin, family 2A, member 2
SCN10A sodium channel, voltage gated, type X alpha subunit
SLC16A6 solute carrier family 16, member 6
SLC35F6 solute carrier family 35, member F6
SLC5A5 solute carrier family 5 (sodium/iodide cotransporter), member 5
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20
SMR3A submaxillary gland androgen regulated protein 3A
SPATA1 spermatogenesis associated 1
SPTLC3 serine palmitoyltransferase, long chain base subunit 3
SUSD5 sushi domain containing 5
TBL1Y transducin (beta)-like 1, Y-linked
TEAD3 TEA domain family member 3
TIGD6 tigger transposable element derived 6
TM7SF2 transmembrane 7 superfamily member 2
TMC5 transmembrane channel-like 5
TUBA4B tubulin, alpha 4b
TWSG1 twisted gastrulation BMP signaling modulator 1
UPB1 ureidopropionase, beta
USB1 U6 snRNA biogenesis 1
USP6NL USP6 N-terminal like
VASH1 vasohibin 1
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae)
ZNF480 zinc finger protein 480
ZNF552 zinc finger protein 552
ZNF667 zinc finger protein 667
ZNF778 zinc finger protein 778