heliotrine-3717 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

195 genes differentially expressed following the heliotrine-3717 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACRV1 acrosomal vesicle protein 1
ADAM28 ADAM metallopeptidase domain 28
ALDH1L1 aldehyde dehydrogenase 1 family, member L1
ANKRD26 ankyrin repeat domain 26
AP2B1 adaptor-related protein complex 2, beta 1 subunit
APP amyloid beta (A4) precursor protein
ARC activity-regulated cytoskeleton-associated protein
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARL2BP ADP-ribosylation factor-like 2 binding protein
ATF6B activating transcription factor 6 beta
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BBC3 BCL2 binding component 3
BTNL3 butyrophilin-like 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C11ORF16 chromosome 11 open reading frame 16
CALU calumenin
CHM choroideremia (Rab escort protein 1)
CLCN4 chloride channel, voltage-sensitive 4
COL6A1 collagen, type VI, alpha 1
DESI2 desumoylating isopeptidase 2
DKFZP434C153 DKFZP434C153 protein
DNAH17 dynein, axonemal, heavy chain 17
DPF1 D4, zinc and double PHD fingers family 1
DRD5 dopamine receptor D5
EGFR epidermal growth factor receptor
EGR1 early growth response 1
FBXO22 F-box protein 22
FCF1 FCF1 rRNA-processing protein
FGF1 fibroblast growth factor 1 (acidic)
FKBP10 FK506 binding protein 10, 65 kDa
GAB1 GRB2-associated binding protein 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)
GM2A GM2 ganglioside activator
GPD2 glycerol-3-phosphate dehydrogenase 2 (mitochondrial)
GPR19 G protein-coupled receptor 19
GPR27 G protein-coupled receptor 27
HAL histidine ammonia-lyase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
IRF4 interferon regulatory factor 4
KAT6A K(lysine) acetyltransferase 6A
KDM5A lysine (K)-specific demethylase 5A
KIDINS220 kinase D-interacting substrate, 220kDa
LIMK2 LIM domain kinase 2
LMAN1 lectin, mannose-binding, 1
LPIN1 lipin 1
MET MET proto-oncogene, receptor tyrosine kinase
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MST1L macrophage stimulating 1-like
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NDP Norrie disease (pseudoglioma)
NDUFAF5 NADH dehydrogenase (ubiquinone) complex I, assembly factor 5
NF1 neurofibromin 1
NOTCH4 notch 4
NPM3 nucleophosmin/nucleoplasmin 3
NXT2 nuclear transport factor 2-like export factor 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PARP6 poly (ADP-ribose) polymerase family, member 6
PBX2 pre-B-cell leukemia homeobox 2
PCDHB13 protocadherin beta 13
PDGFA platelet-derived growth factor alpha polypeptide
PHF20 PHD finger protein 20
PHOX2B paired-like homeobox 2b
PICALM phosphatidylinositol binding clathrin assembly protein
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PKN2 protein kinase N2
PLK4 polo-like kinase 4
PLXND1 plexin D1
POLL polymerase (DNA directed), lambda
POU5F1B POU class 5 homeobox 1B
PQLC2 PQ loop repeat containing 2
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPN21 protein tyrosine phosphatase, non-receptor type 21
RAB6A RAB6A, member RAS oncogene family
RAD23B RAD23 homolog B (S. cerevisiae)
RGS4 regulator of G-protein signaling 4
RNF6 ring finger protein (C3H2C3 type) 6
SCAPER S-phase cyclin A-associated protein in the ER
SCN11A sodium channel, voltage gated, type XI alpha subunit
SELPLG selectin P ligand
SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
SHANK1 SH3 and multiple ankyrin repeat domains 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLCO2A1 solute carrier organic anion transporter family, member 2A1
SNX13 sorting nexin 13
SOS2 son of sevenless homolog 2 (Drosophila)
ST7L suppression of tumorigenicity 7 like
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4
STK16 serine/threonine kinase 16
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
TAF6L TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIM23 tripartite motif containing 23
YY2 YY2 transcription factor
ZEB1 zinc finger E-box binding homeobox 1

decreased expression

Symbol Name
ACVR2B activin A receptor, type IIB
AIPL1 aryl hydrocarbon receptor interacting protein-like 1
ALPK1 alpha-kinase 1
ANP32A-IT1 ANP32A intronic transcript 1
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1
ARPIN actin-related protein 2/3 complex inhibitor
BAHCC1 BAH domain and coiled-coil containing 1
C17ORF70 chromosome 17 open reading frame 70
C5ORF45 chromosome 5 open reading frame 45
CACNA2D2 calcium channel, voltage-dependent, alpha 2/delta subunit 2
CAPN15 calpain 15
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCDC106 coiled-coil domain containing 106
CEP295 centrosomal protein 295kDa
CEP41 centrosomal protein 41kDa
CGREF1 cell growth regulator with EF-hand domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CISH cytokine inducible SH2-containing protein
CLCN6 chloride channel, voltage-sensitive 6
CLSPN claspin
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)
DSPP dentin sialophosphoprotein
ECM1 extracellular matrix protein 1
FBXO2 F-box protein 2
FKRP fukutin related protein
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GINS4 GINS complex subunit 4 (Sld5 homolog)
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLB1L galactosidase, beta 1-like
GPR1 G protein-coupled receptor 1
GRTP1 growth hormone regulated TBC protein 1
GSTT1 glutathione S-transferase theta 1
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa
GUSBP3 glucuronidase, beta pseudogene 3
HIST1H3B histone cluster 1, H3b
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFT22 intraflagellar transport 22
KLF3 Kruppel-like factor 3 (basic)
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LOC390998 ribosomal protein L10 pseudogene
LRRC37A3 leucine rich repeat containing 37, member A3
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1
MFGE8 milk fat globule-EGF factor 8 protein
MRPL44 mitochondrial ribosomal protein L44
MYO1D myosin ID
NACAP1 nascent-polypeptide-associated complex alpha polypeptide pseudogene 1
NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa
NPFFR1 neuropeptide FF receptor 1
NPIPB15 nuclear pore complex interacting protein family, member B15
OGDHL oxoglutarate dehydrogenase-like
PAK3 p21 protein (Cdc42/Rac)-activated kinase 3
PC pyruvate carboxylase
PLAC8 placenta-specific 8
PLXNA3 plexin A3
PPCDC phosphopantothenoylcysteine decarboxylase
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REL v-rel avian reticuloendotheliosis viral oncogene homolog
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFWD3 ring finger and WD repeat domain 3
RNF122 ring finger protein 122
RNF125 ring finger protein 125, E3 ubiquitin protein ligase
RPS14P3 ribosomal protein S14 pseudogene 3
RPS21 ribosomal protein S21
SCEL sciellin
SEPP1 selenoprotein P, plasma, 1
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5
STX1A syntaxin 1A (brain)
SUN2 Sad1 and UNC84 domain containing 2
SUZ12P1 suppressor of zeste 12 homolog pseudogene 1
SYT17 synaptotagmin XVII
TAOK1 TAO kinase 1
TEP1 telomerase-associated protein 1
TGFB3 transforming growth factor, beta 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TINAGL1 tubulointerstitial nephritis antigen-like 1
TMEM121 transmembrane protein 121
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRIM45 tripartite motif containing 45
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae)
UBQLN4 ubiquilin 4
WDR6 WD repeat domain 6
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2
ZNF160 zinc finger protein 160
ZNF264 zinc finger protein 264
ZNF276 zinc finger protein 276
ZNF426 zinc finger protein 426
ZNF551 zinc finger protein 551
ZNF611 zinc finger protein 611
ZNF652 zinc finger protein 652
ZNF721 zinc finger protein 721
ZNF749 zinc finger protein 749