heliotrine-4739 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

198 genes differentially expressed following the heliotrine-4739 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4
ADAM5 ADAM metallopeptidase domain 5 (pseudogene)
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
AOC3 amine oxidase, copper containing 3
APC adenomatous polyposis coli
ARAP1 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL6 B-cell CLL/lymphoma 6
BMP10 bone morphogenetic protein 10
CALCR calcitonin receptor
CAV2 caveolin 2
CCDC64 coiled-coil domain containing 64
CCR1 chemokine (C-C motif) receptor 1
CD209 CD209 molecule
CDK13 cyclin-dependent kinase 13
CLTB clathrin, light chain B
CLTC clathrin, heavy chain (Hc)
CNTNAP2 contactin associated protein-like 2
COL1A1 collagen, type I, alpha 1
CRYGC crystallin, gamma C
CSNK1G1 casein kinase 1, gamma 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DLC1 DLC1 Rho GTPase activating protein
ETV2 ets variant 2
FRMD4B FERM domain containing 4B
GAP43 growth associated protein 43
GLS glutaminase
GPSM3 G-protein signaling modulator 3
GSK3A glycogen synthase kinase 3 alpha
GTDC1 glycosyltransferase-like domain containing 1
HIPK2 homeodomain interacting protein kinase 2
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
HMGN5 high mobility group nucleosome binding domain 5
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1
HSF1 heat shock transcription factor 1
HYAL3 hyaluronoglucosaminidase 3
ICA1 islet cell autoantigen 1, 69kDa
ICOSLG inducible T-cell co-stimulator ligand
IFNW1 interferon, omega 1
IRF5 interferon regulatory factor 5
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
ITM2C integral membrane protein 2C
KRT14 keratin 14, type I
KRT9 keratin 9, type I
LAMB4 laminin, beta 4
LIMK2 LIM domain kinase 2
LMX1B LIM homeobox transcription factor 1, beta
LRCH4 leucine-rich repeats and calponin homology (CH) domain containing 4
MAB21L1 mab-21-like 1 (C. elegans)
MALT1 MALT1 paracaspase
MAPT microtubule-associated protein tau
MED25 mediator complex subunit 25
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MNDA myeloid cell nuclear differentiation antigen
MOB3B MOB kinase activator 3B
MST1 macrophage stimulating 1
MUC3A mucin 3A, cell surface associated
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NUP188 nucleoporin 188kDa
OPRL1 opiate receptor-like 1
OR1D2 olfactory receptor, family 1, subfamily D, member 2
OXCT2 3-oxoacid CoA transferase 2
PBOV1 prostate and breast cancer overexpressed 1
PCDHB11 protocadherin beta 11
PCDHGA3 protocadherin gamma subfamily A, 3
PDPR pyruvate dehydrogenase phosphatase regulatory subunit
PEG10 paternally expressed 10
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PPP1R2P9 protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9
PRKCE protein kinase C, epsilon
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa
PTK2B protein tyrosine kinase 2 beta
PTRF polymerase I and transcript release factor
PVRL3 poliovirus receptor-related 3
RAB6B RAB6B, member RAS oncogene family
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCAND2P SCAN domain containing 2 pseudogene
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC30A3 solute carrier family 30 (zinc transporter), member 3
SMAD1 SMAD family member 1
SRPR signal recognition particle receptor (docking protein)
STAB2 stabilin 2
SYNC syncoilin, intermediate filament protein
TAGLN3 transgelin 3
TCP10 t-complex 10
TJAP1 tight junction associated protein 1 (peripheral)
TMCC2 transmembrane and coiled-coil domain family 2
TMLHE trimethyllysine hydroxylase, epsilon
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TPSD1 tryptase delta 1
TTPA tocopherol (alpha) transfer protein
VWA5A von Willebrand factor A domain containing 5A
WDR55 WD repeat domain 55
YY2 YY2 transcription factor
ZNF155 zinc finger protein 155
ZNF639 zinc finger protein 639

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ACTL8 actin-like 8
ARPIN actin-related protein 2/3 complex inhibitor
ATG2A autophagy related 2A
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCORL1 BCL6 corepressor-like 1
BFSP1 beaded filament structural protein 1, filensin
C11ORF80 chromosome 11 open reading frame 80
C1ORF21 chromosome 1 open reading frame 21
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CAMK1 calcium/calmodulin-dependent protein kinase I
CARF calcium responsive transcription factor
CCRL2 chemokine (C-C motif) receptor-like 2
CDADC1 cytidine and dCMP deaminase domain containing 1
CDK20 cyclin-dependent kinase 20
CEP97 centrosomal protein 97kDa
CISH cytokine inducible SH2-containing protein
CLIC2 chloride intracellular channel 2
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DEAF1 DEAF1 transcription factor
DGKE diacylglycerol kinase, epsilon 64kDa
DNAJC28 DnaJ (Hsp40) homolog, subfamily C, member 28
DNAL4 dynein, axonemal, light chain 4
DNM1 dynamin 1
DSPP dentin sialophosphoprotein
DYM dymeclin
EVPL envoplakin
F2R coagulation factor II (thrombin) receptor
FAM189A2 family with sequence similarity 189, member A2
FAM46C family with sequence similarity 46, member C
FBXL2 F-box and leucine-rich repeat protein 2
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
FLCN folliculin
GATA4 GATA binding protein 4
GUSBP3 glucuronidase, beta pseudogene 3
HCG4 HLA complex group 4 (non-protein coding)
HIRA histone cell cycle regulator
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
HYI hydroxypyruvate isomerase (putative)
IFT81 intraflagellar transport 81
INPP5J inositol polyphosphate-5-phosphatase J
IQCG IQ motif containing G
KCNMB1 potassium channel subfamily M regulatory beta subunit 1
LOC100287590 uncharacterized LOC100287590
LRRC37A3 leucine rich repeat containing 37, member A3
LTBP2 latent transforming growth factor beta binding protein 2
LY6G6C lymphocyte antigen 6 complex, locus G6C
MEFV Mediterranean fever
MMRN2 multimerin 2
MOCS3 molybdenum cofactor synthesis 3
MXD3 MAX dimerization protein 3
NOTCH1 notch 1
NPTX1 neuronal pentraxin I
OLFML2A olfactomedin-like 2A
OR2F1 olfactory receptor, family 2, subfamily F, member 1 (gene/pseudogene)
P2RY1 purinergic receptor P2Y, G-protein coupled, 1
PER3 period circadian clock 3
PGPEP1 pyroglutamyl-peptidase I
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PLAT plasminogen activator, tissue
POLL polymerase (DNA directed), lambda
POM121 POM121 transmembrane nucleoporin
POMT2 protein-O-mannosyltransferase 2
PRSS53 protease, serine, 53
PTPRS protein tyrosine phosphatase, receptor type, S
RAB36 RAB36, member RAS oncogene family
RAB3IL1 RAB3A interacting protein (rabin3)-like 1
RAI2 retinoic acid induced 2
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2
RASAL1 RAS protein activator like 1 (GAP1 like)
RFPL3 ret finger protein-like 3
RPL23AP32 ribosomal protein L23a pseudogene 32
SAMD9 sterile alpha motif domain containing 9
SAYSD1 SAYSVFN motif domain containing 1
SCHIP1 schwannomin interacting protein 1
SDC3 syndecan 3
SEC14L2 SEC14-like 2 (S. cerevisiae)
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SHPK sedoheptulokinase
SIK1 salt-inducible kinase 1
STX1A syntaxin 1A (brain)
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TFF2 trefoil factor 2
TICAM1 toll-like receptor adaptor molecule 1
TNKS2 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
TRABD TraB domain containing
VGF VGF nerve growth factor inducible
VIPR1 vasoactive intestinal peptide receptor 1
VPS9D1 VPS9 domain containing 1
ZBTB33 zinc finger and BTB domain containing 33
ZNF137P zinc finger protein 137, pseudogene
ZNF180 zinc finger protein 180
ZNF652 zinc finger protein 652
ZNF747 zinc finger protein 747