hellp syndrome Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A severe pre-eclampsia characterized by hemolysis, elevated liver enzyme and low platelet count. (Human Disease Ontology, DOID_13133)
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Genes

104 genes co-occuring with the disease hellp syndrome in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.432
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 1.4263
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 1.3987
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 1.36335
HP haptoglobin 1.34374
HPR haptoglobin-related protein 1.33676
F5 coagulation factor V (proaccelerin, labile factor) 1.30576
LGALS13 lectin, galactoside-binding, soluble, 13 1.20785
PGF placental growth factor 1.1422
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 1.06858
PAPPA2 pappalysin 2 1.0606
STOX1 storkhead box 1 1.05261
F2 coagulation factor II (thrombin) 1.04083
FLT1 fms-related tyrosine kinase 1 0.935799
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 0.866731
ADAM12 ADAM metallopeptidase domain 12 0.801154
PMCH pro-melanin-concentrating hormone 0.797052
HADH hydroxyacyl-CoA dehydrogenase 0.768393
ACVR2A activin A receptor, type IIA 0.715618
HLA-E major histocompatibility complex, class I, E 0.619442
F3 coagulation factor III (thromboplastin, tissue factor) 0.592116
PAPPA pregnancy-associated plasma protein A, pappalysin 1 0.544318
VWF von Willebrand factor 0.536183
SDC1 syndecan 1 0.532314
HPD 4-hydroxyphenylpyruvate dioxygenase 0.528063
CTHRC1 collagen triple helix repeat containing 1 0.501909
APEH acylaminoacyl-peptide hydrolase 0.49274
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 0.468819
INHA inhibin, alpha 0.448441
AHSP alpha hemoglobin stabilizing protein 0.443547
PROS1 protein S (alpha) 0.442042
WWTR1 WW domain containing transcription regulator 1 0.438282
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.429642
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic) 0.424389
FBXW2 F-box and WD repeat domain containing 2 0.413901
THBD thrombomodulin 0.412031
PARVA parvin, alpha 0.403811
KLRC2 killer cell lectin-like receptor subfamily C, member 2 0.400826
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.400453
CD46 CD46 molecule, complement regulatory protein 0.391885
GSTA1 glutathione S-transferase alpha 1 0.383337
ALB albumin 0.379626
LRSAM1 leucine rich repeat and sterile alpha motif containing 1 0.378885
F8 coagulation factor VIII, procoagulant component 0.378885
RAET1E retinoic acid early transcript 1E 0.374438
PNMA1 paraneoplastic Ma antigen 1 0.368518
PLG plasminogen 0.367779
LHB luteinizing hormone beta polypeptide 0.364454
CGB7 chorionic gonadotropin, beta polypeptide 7 0.361133
CGB5 chorionic gonadotropin, beta polypeptide 5 0.359657
CORIN corin, serine peptidase 0.359289
FAM155B family with sequence similarity 155, member B 0.357446
SUOX sulfite oxidase 0.35082
TGFB3 transforming growth factor, beta 3 0.340906
ACADVL acyl-CoA dehydrogenase, very long chain 0.336144
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 0.336144
CGB chorionic gonadotropin, beta polypeptide 0.336144
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 0.336144
C5AR1 complement component 5a receptor 1 0.335778
CGB8 chorionic gonadotropin, beta polypeptide 8 0.335412
CPT2 carnitine palmitoyltransferase 2 0.333949
LAMP3 lysosomal-associated membrane protein 3 0.332121
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain 0.325916
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 0.323365
TALDO1 transaldolase 1 0.315003
PROC protein C (inactivator of coagulation factors Va and VIIIa) 0.304864
LY75 lymphocyte antigen 75 0.302698
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 0.299452
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.288668
PIGF phosphatidylinositol glycan anchor biosynthesis, class F 0.281153
CFI complement factor I 0.279011
AFP alpha-fetoprotein 0.277227
GSTP1 glutathione S-transferase pi 1 0.259477
ERAP1 endoplasmic reticulum aminopeptidase 1 0.257358
BBS1 Bardet-Biedl syndrome 1 0.257358
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.247501
HSPA1B heat shock 70kDa protein 1B 0.238054
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.23666
TREM1 triggering receptor expressed on myeloid cells 1 0.23353
TNF tumor necrosis factor 0.230755
VCAM1 vascular cell adhesion molecule 1 0.227642
FGR FGR proto-oncogene, Src family tyrosine kinase 0.226607
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.216332
CD8B CD8b molecule 0.214297
KLRC1 killer cell lectin-like receptor subfamily C, member 1 0.210253
ERVW-1 endogenous retrovirus group W, member 1 0.209248
FN1 fibronectin 1 0.20658
HES5 hes family bHLH transcription factor 5 0.196779
MMP8 matrix metallopeptidase 8 0.189244
ICAM1 intercellular adhesion molecule 1 0.189244
GPR182 G protein-coupled receptor 182 0.187719
HSPA4 heat shock 70kDa protein 4 0.185016
APOH apolipoprotein H (beta-2-glycoprotein I) 0.183835
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 0.176215
ALPPL2 alkaline phosphatase, placental-like 2 0.173057
ALPP alkaline phosphatase, placental 0.172799
ALPL alkaline phosphatase, liver/bone/kidney 0.172544
TIMP1 TIMP metallopeptidase inhibitor 1 0.167915
TTR transthyretin 0.167682
PIGA phosphatidylinositol glycan anchor biosynthesis, class A 0.163938
GSTA3 glutathione S-transferase alpha 3 0.162908
GSTA2 glutathione S-transferase alpha 2 0.162306
GSTA4 glutathione S-transferase alpha 4 0.161716
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 0.160574