hemophagocytic lymphohistiocytosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description A lymphatic system disease that is characterized by an expansion of the monocyte-macrophage population and intense hemophagocytosis. It can occur de novo, but more often occurs in the setting of another disorder, usually an infection or a malignancy. A clinical picture of fever, hepatosplenomegaly, lymphadenopathy and peripheral pancytopenia. The morphologic hallmark of this syndrome is the phagocytosis of hematopoietic elements by morphologically normal macrophages. (Human Disease Ontology, DOID_0050120)
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Genes

165 genes co-occuring with the disease hemophagocytic lymphohistiocytosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
UNC13D unc-13 homolog D (C. elegans) 2.89721
STX11 syntaxin 11 2.68029
PRF1 perforin 1 (pore forming protein) 2.54184
STXBP2 syntaxin binding protein 2 2.3897
RAB27A RAB27A, member RAS oncogene family 2.11582
FHL2 four and a half LIM domains 2 2.0767
FTL ferritin, light polypeptide 2.06307
FTH1 ferritin, heavy polypeptide 1 2.06261
SH2D1A SH2 domain containing 1A 2.02794
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 1.50711
LYST lysosomal trafficking regulator 1.47198
IL2RA interleukin 2 receptor, alpha 1.44869
AHSG alpha-2-HS-glycoprotein 1.33807
NCAM1 neural cell adhesion molecule 1 1.31362
UNC13B unc-13 homolog B (C. elegans) 1.29833
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.21695
IVL involucrin 1.20872
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.20093
RAB17 RAB17, member RAS oncogene family 1.17722
TIA1 TIA1 cytotoxic granule-associated RNA binding protein 1.1194
VTI1B vesicle transport through interaction with t-SNAREs 1B 1.08999
MYO5A myosin VA (heavy chain 12, myoxin) 1.05976
EXOSC8 exosome component 8 1.04209
RAB20 RAB20, member RAS oncogene family 1.00288
RAB37 RAB37, member RAS oncogene family 0.940364
PDLIM7 PDZ and LIM domain 7 (enigma) 0.936629
CD5 CD5 molecule 0.933727
NUP153 nucleoporin 153kDa 0.927105
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.915963
RAB28 RAB28, member RAS oncogene family 0.915551
RAB6A RAB6A, member RAS oncogene family 0.908553
TNF tumor necrosis factor 0.89582
CD4 CD4 molecule 0.890488
RAB10 RAB10, member RAS oncogene family 0.813462
NSF N-ethylmaleimide-sensitive factor 0.811001
LACTB2 lactamase, beta 2 0.785574
RAB18 RAB18, member RAS oncogene family 0.763902
AARSD1 alanyl-tRNA synthetase domain containing 1 0.752085
CD68 CD68 molecule 0.748017
IL6 interleukin 6 0.743954
LAMP1 lysosomal-associated membrane protein 1 0.739894
KRAS Kirsten rat sarcoma viral oncogene homolog 0.735433
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.732191
CD163 CD163 molecule 0.730976
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 0.730976
SNAP23 synaptosomal-associated protein, 23kDa 0.725716
STXBP1 syntaxin binding protein 1 0.700722
MLPH melanophilin 0.695905
CRP C-reactive protein, pentraxin-related 0.688291
SYTL5 synaptotagmin-like 5 0.677105
RAB2A RAB2A, member RAS oncogene family 0.670732
CD34 CD34 molecule 0.667152
RAB11A RAB11A, member RAS oncogene family 0.665166
MLH1 mutL homolog 1 0.632384
NAAA N-acylethanolamine acid amidase 0.629635
RAB5A RAB5A, member RAS oncogene family 0.626103
HRAS Harvey rat sarcoma viral oncogene homolog 0.623751
APLF aprataxin and PNKP like factor 0.616312
IL2 interleukin 2 0.615921
RAB23 RAB23, member RAS oncogene family 0.615138
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.606933
STX7 syntaxin 7 0.605762
TTC37 tetratricopeptide repeat domain 37 0.59952
IL1RN interleukin 1 receptor antagonist 0.594454
FBXO3 F-box protein 3 0.592116
FGFBP2 fibroblast growth factor binding protein 2 0.584719
CD19 CD19 molecule 0.581996
OR10A4 olfactory receptor, family 10, subfamily A, member 4 0.581606
VAMP8 vesicle-associated membrane protein 8 0.578883
GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial 0.576939
HPR haptoglobin-related protein 0.56722
IL18 interleukin 18 0.553627
UBASH3B ubiquitin associated and SH3 domain containing B 0.544705
MAGT1 magnesium transporter 1 0.534248
CORO1A coronin, actin binding protein, 1A 0.523816
CDH9 cadherin 9, type 2 (T1-cadherin) 0.523045
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 0.521117
HP haptoglobin 0.518034
SKIV2L superkiller viralicidic activity 2-like (S. cerevisiae) 0.503824
SLAMF1 signaling lymphocytic activation molecule family member 1 0.502675
MSTO1 misato 1, mitochondrial distribution and morphology regulator 0.501909
MUC6 mucin 6, oligomeric mucus/gel-forming 0.496557
PFKP phosphofructokinase, platelet 0.467306
RAB3A RAB3A, member RAS oncogene family 0.46655
GLIS2 GLIS family zinc finger 2 0.456732
SP110 SP110 nuclear body protein 0.453716
PRB2 proline-rich protein BstNI subfamily 2 0.448441
TRIM46 tripartite motif containing 46 0.447687
CD7 CD7 molecule 0.433772
PDZK1IP1 PDZK1 interacting protein 1 0.42214
SCG2 secretogranin II 0.41465
IRF6 interferon regulatory factor 6 0.410535
RPE ribulose-5-phosphate-3-epimerase 0.410161
ITK IL2-inducible T-cell kinase 0.409414
IL1B interleukin 1, beta 0.407919
IL18BP interleukin 18 binding protein 0.404931
B2M beta-2-microglobulin 0.393746
TRIM33 tripartite motif containing 33 0.389281
STXBP3 syntaxin binding protein 3 0.388538
STX3 syntaxin 3 0.387794
TP63 tumor protein p63 0.384451
RAB8A RAB8A, member RAS oncogene family 0.377402
WNT10A wingless-type MMTV integration site family, member 10A 0.372217
GNLY granulysin 0.359289
U2AF2 U2 small nuclear RNA auxiliary factor 2 0.356709
RAB4A RAB4A, member RAS oncogene family 0.353763
STX6 syntaxin 6 0.350452
UNC13A unc-13 homolog A (C. elegans) 0.344941
B3GAT1 beta-1,3-glucuronyltransferase 1 0.342372
PTPRC protein tyrosine phosphatase, receptor type, C 0.321181
ARSI arylsulfatase family, member I 0.318635
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like 0.318272
TCF3 transcription factor 3 0.317182
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 0.316456
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7 0.313915
CD84 CD84 molecule 0.313189
F3 coagulation factor III (thromboplastin, tissue factor) 0.307757
ZBTB32 zinc finger and BTB domain containing 32 0.304503
FBXO2 F-box protein 2 0.30342
MIXL1 Mix paired-like homeobox 0.299452
CXCL9 chemokine (C-X-C motif) ligand 9 0.298731
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 0.295851
RELT RELT tumor necrosis factor receptor 0.295132
CDKN2A cyclin-dependent kinase inhibitor 2A 0.293694
ATF5 activating transcription factor 5 0.292975
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) 0.291898
ALK anaplastic lymphoma receptor tyrosine kinase 0.290103
SPOP speckle-type POZ protein 0.285086
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 0.282225
MUC2 mucin 2, oligomeric mucus/gel-forming 0.281868
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.279367
U2AF1 U2 small nuclear RNA auxiliary factor 1 0.275445
HLA-C major histocompatibility complex, class I, C 0.275089
FAM131C family with sequence similarity 131, member C 0.264785
ALB albumin 0.264431
TP53 tumor protein p53 0.260891
CD52 CD52 molecule 0.25877
VASH1 vasohibin 1 0.250311
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.245396
CD79A CD79a molecule, immunoglobulin-associated alpha 0.241196
TMEM245 transmembrane protein 245 0.237357
ALDOC aldolase C, fructose-bisphosphate 0.232142
CD1A CD1a molecule 0.231448
CXCL10 chemokine (C-X-C motif) ligand 10 0.230063
RAB25 RAB25, member RAS oncogene family 0.230063
ASRGL1 asparaginase like 1 0.221108
THBD thrombomodulin 0.212608
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 0.207245
LYZ lysozyme 0.196139
STX4 syntaxin 4 0.192031
COL14A1 collagen, type XIV, alpha 1 0.187113
PDXP pyridoxal (pyridoxine, vitamin B6) phosphatase 0.184128
LGMN legumain 0.180084
SHD Src homology 2 domain containing transforming protein D 0.179239
CX3CL1 chemokine (C-X3-C motif) ligand 1 0.178682
PARD6A par-6 family cell polarity regulator alpha 0.178682
HPX hemopexin 0.178126
MSH2 mutS homolog 2 0.175146
MIR27B microRNA 27b 0.175146
WRAP73 WD repeat containing, antisense to TP73 0.175146
KRT20 keratin 20, type I 0.174617
SRGN serglycin 0.172038
ARF6 ADP-ribosylation factor 6 0.161523
INSC inscuteable homolog (Drosophila) 0.158951
ALDOB aldolase B, fructose-bisphosphate 0.158097