heparin Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A highly sulfated linear glycosaminoglycan comprising complex patterns of uronic acid-(1->4)-D-glucosamine repeating subunits. Used as an injectable anticoagulant, it has the highest negative charge density of any known biological molecule. (Chemical Entities of Biological Interest Ontology, CHEBI_28304)
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Genes

148 genes co-occuring with the biological term heparin in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ANGPT1 angiopoietin 1
ANOS1 anosmin 1
ANXA2 annexin A2
APLP1 amyloid beta (A4) precursor-like protein 1
APOA5 apolipoprotein A-V
APOE apolipoprotein E
APOH apolipoprotein H (beta-2-glycoprotein I)
APP amyloid beta (A4) precursor protein
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
B2M beta-2-microglobulin
BACE1 beta-site APP-cleaving enzyme 1
BGLAP bone gamma-carboxyglutamate (gla) protein
BMP2 bone morphogenetic protein 2
C3 complement component 3
C6ORF25 chromosome 6 open reading frame 25
CALB2 calbindin 2
CCL2 chemokine (C-C motif) ligand 2
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CFH complement factor H
CFHR5 complement factor H-related 5
CMA1 chymase 1, mast cell
COL13A1 collagen, type XIII, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COL25A1 collagen, type XXV, alpha 1
CR1 complement component (3b/4b) receptor 1 (Knops blood group)
CSF2 colony stimulating factor 2 (granulocyte-macrophage)
CTSD cathepsin D
CTSL cathepsin L
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYR61 cysteine-rich, angiogenic inducer, 61
DCC DCC netrin 1 receptor
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFEMP2 EGF containing fibulin-like extracellular matrix protein 2
EGR1 early growth response 1
ELANE elastase, neutrophil expressed
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EVA1C eva-1 homolog C (C. elegans)
F10 coagulation factor X
F2 coagulation factor II (thrombin)
F2R coagulation factor II (thrombin) receptor
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
FBLN5 fibulin 5
FBN1 fibrillin 1
FGF1 fibroblast growth factor 1 (acidic)
FGF2 fibroblast growth factor 2 (basic)
FGFBP3 fibroblast growth factor binding protein 3
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FGG fibrinogen gamma chain
FIGF c-fos induced growth factor (vascular endothelial growth factor D)
FN1 fibronectin 1
FOXA1 forkhead box A1
FST follistatin
FURIN furin (paired basic amino acid cleaving enzyme)
GDNF glial cell derived neurotrophic factor
GFRA1 GDNF family receptor alpha 1
GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
GSN gelsolin
HABP2 hyaluronan binding protein 2
HBEGF heparin-binding EGF-like growth factor
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HPSE heparanase
HRG histidine-rich glycoprotein
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5
HSPA1A heat shock 70kDa protein 1A
HSPG2 heparan sulfate proteoglycan 2
IAPP islet amyloid polypeptide
ICAM1 intercellular adhesion molecule 1
IFNK interferon, kappa
IGF2 insulin-like growth factor 2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IL10 interleukin 10
IL12B interleukin 12B
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
JUN jun proto-oncogene
KDR kinase insert domain receptor
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KNG1 kininogen 1
LACRT lacritin
LPL lipoprotein lipase
LTF lactotransferrin
MAPK14 mitogen-activated protein kinase 14
MAPT microtubule-associated protein tau
MDK midkine (neurite growth-promoting factor 2)
MIR10B microRNA 10b
MIR633 microRNA 633
MMP9 matrix metallopeptidase 9
NCR1 natural cytotoxicity triggering receptor 1
NID2 nidogen 2 (osteonidogen)
NOS3 nitric oxide synthase 3 (endothelial cell)
NTN1 netrin 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PF4 platelet factor 4
PF4V1 platelet factor 4 variant 1
PLAT plasminogen activator, tissue
PRKCD protein kinase C, delta
PRL prolactin
PRNP prion protein
PROC protein C (inactivator of coagulation factors Va and VIIIa)
PTN pleiotrophin
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RET ret proto-oncogene
RHOA ras homolog family member A
RNASE3 ribonuclease, RNase A family, 3
ROCK1 Rho-associated, coiled-coil containing protein kinase 1
RPL29 ribosomal protein L29
RUNX2 runt-related transcription factor 2
SDC1 syndecan 1
SELE selectin E
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SERPINA10 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SFRP1 secreted frizzled-related protein 1
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOST sclerostin
STAB2 stabilin 2
SULF2 sulfatase 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
THBS1 thrombospondin 1
TIMP1 TIMP metallopeptidase inhibitor 1
TNF tumor necrosis factor
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPPP tubulin polymerization promoting protein
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
VASH1 vasohibin 1
VEGFA vascular endothelial growth factor A
VTN vitronectin
VWF von Willebrand factor
WNT7A wingless-type MMTV integration site family, member 7A