hepatobiliary disease Gene Set

Dataset GWASdb SNP-Disease Associations
Category disease or phenotype associations
Type disease
Description A gastrointestinal system disease that is located_in the liver and/or biliary tract. (Human Disease Ontology, DOID_3118)
External Link http://jjwanglab.org/gwasdb/gwasdb2/gwasdb2/go_trait/DOID:3118
Similar Terms
Downloads & Tools

Genes

301 genes associated with the disease hepatobiliary disease in GWAS and other genetic association datasets from the GWASdb SNP-Disease Associations dataset.

Symbol Name Standardized Value
HECTD4 HECT domain containing E3 ubiquitin protein ligase 4 1.98115
GGT1 gamma-glutamyltransferase 1 1.85982
PNPLA3 patatin-like phospholipase domain containing 3 1.25847
HNF1A HNF1 homeobox A 1.24287
ABO ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase) 1.17253
EXOC3L4 exocyst complex component 3-like 4 1.13811
C6ORF10 chromosome 6 open reading frame 10 0.926769
HCP5 HLA complex P5 (non-protein coding) 0.846913
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.737204
ZNF827 zinc finger protein 827 0.62866
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.617774
GPLD1 glycosylphosphatidylinositol specific phospholipase D1 0.599806
RORA RAR-related orphan receptor A 0.550877
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 0.544477
JMJD1C jumonji domain containing 1C 0.523911
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.47748
GCKR glucokinase (hexokinase 4) regulator 0.475601
IL12RB2 interleukin 12 receptor, beta 2 0.47324
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 0.471183
HPN hepsin 0.469238
TNPO3 transportin 3 0.459788
MST1 macrophage stimulating 1 0.459441
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.459441
FUT2 fucosyltransferase 2 (secretor status included) 0.45009
MIR22HG MIR22 host gene 0.438494
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 0.432897
C12ORF43 chromosome 12 open reading frame 43 0.429876
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 0.423308
BTNL2 butyrophilin-like 2 0.422977
RPL3 ribosomal protein L3 0.414012
OASL 2'-5'-oligoadenylate synthetase-like 0.412202
CLEC16A C-type lectin domain family 16, member A 0.408185
BAG6 BCL2-associated athanogene 6 0.406699
MYO1B myosin IB 0.400243
RAD51B RAD51 paralog B 0.395491
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 0.392772
TIMMDC1 translocase of inner mitochondrial membrane domain containing 1 0.39241
HLA-DRA major histocompatibility complex, class II, DR alpha 0.389745
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 0.387193
EHMT2 euchromatic histone-lysine N-methyltransferase 2 0.387045
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.378502
RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4 0.377574
ARHGAP31 Rho GTPase activating protein 31 0.377254
TMEM39A transmembrane protein 39A 0.376192
ITGA1 integrin, alpha 1 0.374281
SLC39A11 solute carrier family 39, member 11 0.373979
IL7R interleukin 7 receptor 0.373861
PBX2 pre-B-cell leukemia homeobox 2 0.371683
WDR70 WD repeat domain 70 0.370575
LOC100506272 uncharacterized LOC100506272 0.36929
DLG5 discs, large homolog 5 (Drosophila) 0.368588
ABHD12 abhydrolase domain containing 12 0.367294
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.365191
EFHD1 EF-hand domain family, member D1 0.364313
CD276 CD276 molecule 0.364313
PRRC2A proline-rich coiled-coil 2A 0.363828
GPANK1 G patch domain and ankyrin repeats 1 0.360895
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 0.358579
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 0.358579
GPR35 G protein-coupled receptor 35 0.358579
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 0.358579
IKZF3 IKAROS family zinc finger 3 (Aiolos) 0.358579
DENND1B DENN/MADD domain containing 1B 0.358296
MLIP muscular LMNA-interacting protein 0.355031
MLXIPL MLX interacting protein-like 0.355031
FADS2 fatty acid desaturase 2 0.355031
ASTN2 astrotactin 2 0.35372
RPS11 ribosomal protein S11 0.34876
CEPT1 choline/ethanolamine phosphotransferase 1 0.347378
ELL2 elongation factor, RNA polymerase II, 2 0.344196
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 0.344196
PRDM16 PR domain containing 16 0.34319
AK8 adenylate kinase 8 0.341173
STK26 serine/threonine protein kinase 26 0.340378
FRMD5 FERM domain containing 5 0.337331
PPARG peroxisome proliferator-activated receptor gamma 0.337331
PLCL2 phospholipase C-like 2 0.337331
MED1 mediator complex subunit 1 0.335892
TCF4 transcription factor 4 0.333169
CSMD1 CUB and Sushi multiple domains 1 0.332758
PRICKLE1 prickle homolog 1 (Drosophila) 0.331032
COL17A1 collagen, type XVII, alpha 1 0.330317
ELMO1 engulfment and cell motility 1 0.33024
TP63 tumor protein p63 0.329183
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 0.327066
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3 0.322914
CDK12 cyclin-dependent kinase 12 0.319215
SDK1 sidekick cell adhesion molecule 1 0.319006
LY6G5B lymphocyte antigen 6 complex, locus G5B 0.316434
FRMD7 FERM domain containing 7 0.313554
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.312353
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.311269
FBXL20 F-box and leucine-rich repeat protein 20 0.310282
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 0.30916
PAX3 paired box 3 0.305539
GRIK1 glutamate receptor, ionotropic, kainate 1 0.304447
CNTN5 contactin 5 0.304239
CELF2 CUGBP, Elav-like family member 2 0.304137
HPCAL1 hippocalcin-like 1 0.302532
GLI3 GLI family zinc finger 3 0.302501
MANBA mannosidase, beta A, lysosomal 0.301347
LMX1A LIM homeobox transcription factor 1, alpha 0.298636
CHRNA3 cholinergic receptor, nicotinic, alpha 3 (neuronal) 0.298636
LY86-AS1 LY86 antisense RNA 1 0.296486
GAS7 growth arrest-specific 7 0.293966
IL2RA interleukin 2 receptor, alpha 0.293966
GOT1 glutamic-oxaloacetic transaminase 1, soluble 0.293204
STAT4 signal transducer and activator of transcription 4 0.291804
HDAC7 histone deacetylase 7 0.291804
LINC00540 long intergenic non-protein coding RNA 540 0.290421
CCDC88B coiled-coil domain containing 88B 0.290421
PLXNA4 plexin A4 0.287361
HNF4A hepatocyte nuclear factor 4, alpha 0.285611
PTPRU protein tyrosine phosphatase, receptor type, U 0.285611
CERS3 ceramide synthase 3 0.28553
LBH limb bud and heart development 0.283877
TMEM117 transmembrane protein 117 0.283187
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.282366
ACOT9 acyl-CoA thioesterase 9 0.280067
VPS26B vacuolar protein sorting 26 homolog B (S. pombe) 0.279459
KIF3A kinesin family member 3A 0.279067
MAMDC2 MAM domain containing 2 0.278435
ITPK1 inositol-tetrakisphosphate 1-kinase 0.277948
BSPRY B-box and SPRY domain containing 0.277592
AIF1 allograft inflammatory factor 1 0.277131
CORO2A coronin, actin binding protein, 2A 0.276463
CCDC102B coiled-coil domain containing 102B 0.275929
GMDS GDP-mannose 4,6-dehydratase 0.275011
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.274669
ALG10B ALG10B, alpha-1,2-glucosyltransferase 0.273596
KIRREL3 kin of IRRE like 3 (Drosophila) 0.273065
LOC643542 uncharacterized LOC643542 0.272302
MCTP2 multiple C2 domains, transmembrane 2 0.271419
GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 0.271419
THSD7B thrombospondin, type I, domain containing 7B 0.271419
RGS5 regulator of G-protein signaling 5 0.271419
EFHC2 EF-hand domain (C-terminal) containing 2 0.271187
TRPM1 transient receptor potential cation channel, subfamily M, member 1 0.269586
EXOC1 exocyst complex component 1 0.26901
LOC100505718 0.268911
LMF1 lipase maturation factor 1 0.267052
C5ORF30 chromosome 5 open reading frame 30 0.265478
MAPT microtubule-associated protein tau 0.265244
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.265141
PCBP3 poly(rC) binding protein 3 0.264588
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.263132
ETNK2 ethanolamine kinase 2 0.262778
COLEC12 collectin sub-family member 12 0.262691
HSF2 heat shock transcription factor 2 0.261363
DMD dystrophin 0.260875
KLF5 Kruppel-like factor 5 (intestinal) 0.260366
ABHD17C abhydrolase domain containing 17C 0.259642
CDH13 cadherin 13 0.259071
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 0.258953
ADAMTS17 ADAM metallopeptidase with thrombospondin type 1 motif, 17 0.25844
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.25844
ARHGAP15 Rho GTPase activating protein 15 0.257519
IFT38 intraflagellar transport 38 0.2572
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase 0.256012
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.255849
VWC2L von Willebrand factor C domain containing protein 2-like 0.253436
ART3 ADP-ribosyltransferase 3 0.251829
TENM4 teneurin transmembrane protein 4 0.249018
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8 0.247772
ALDH1A3 aldehyde dehydrogenase 1 family, member A3 0.247673
MAN2A1 mannosidase, alpha, class 2A, member 1 0.246521
IL23R interleukin 23 receptor 0.245974
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) 0.245445
KCNJ3 potassium channel, inwardly rectifying subfamily J, member 3 0.244435
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 0.244353
RNF34 ring finger protein 34, E3 ubiquitin protein ligase 0.24356
MCTP1 multiple C2 domains, transmembrane 1 0.242953
NLRP5 NLR family, pyrin domain containing 5 0.242223
SPAG16 sperm associated antigen 16 0.241662
LAMA4 laminin, alpha 4 0.24112
UBASH3A ubiquitin associated and SH3 domain containing A 0.240987
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 0.239716
PSORS1C1 psoriasis susceptibility 1 candidate 1 0.238254
RAP1GAP2 RAP1 GTPase activating protein 2 0.237705
ADD3 adducin 3 (gamma) 0.237121
THBS2 thrombospondin 2 0.236914
HID1 HID1 domain containing 0.23621
HDAC4 histone deacetylase 4 0.234751
TNRC18 trinucleotide repeat containing 18 0.234661
LOC100506944 uncharacterized LOC100506944 0.234047
MFSD4 major facilitator superfamily domain containing 4 0.234047
VIT vitrin 0.233086
CD9 CD9 molecule 0.232885
STK35 serine/threonine kinase 35 0.232295
SYN3 synapsin III 0.231989
FHIT fragile histidine triad 0.231505
GNAS GNAS complex locus 0.231214
TDRD5 tudor domain containing 5 0.231177
ENPEP glutamyl aminopeptidase (aminopeptidase A) 0.231142
WDR7 WD repeat domain 7 0.230716
NELL1 NEL-like 1 (chicken) 0.230167
ACAD9 acyl-CoA dehydrogenase family, member 9 0.228395
PTGFRN prostaglandin F2 receptor inhibitor 0.228165
GFRA2 GDNF family receptor alpha 2 0.22746
PVT1 Pvt1 oncogene (non-protein coding) 0.227335
SERINC5 serine incorporator 5 0.227272
CREB3L3 cAMP responsive element binding protein 3-like 3 0.226995
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit 0.225987
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.225144
TPD52L1 tumor protein D52-like 1 0.225116
PRKCA protein kinase C, alpha 0.225061
SLC26A9 solute carrier family 26 (anion exchanger), member 9 0.22498
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.224524
GRIA4 glutamate receptor, ionotropic, AMPA 4 0.224262
NEB nebulin 0.224106
UTRN utrophin 0.224081
NR2C2 nuclear receptor subfamily 2, group C, member 2 0.223178
FBXO39 F-box protein 39 0.222648
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.221817
CASC15 cancer susceptibility candidate 15 (non-protein coding) 0.221749
STAB1 stabilin 1 0.221593
LOC339622 uncharacterized LOC339622 0.221438
PRKCE protein kinase C, epsilon 0.22135
XPO7 exportin 7 0.221045
SLIT2 slit homolog 2 (Drosophila) 0.221045
WFDC3 WAP four-disulfide core domain 3 0.220746
DAAM2 dishevelled associated activator of morphogenesis 2 0.220205
SLCO3A1 solute carrier organic anion transporter family, member 3A1 0.220042
SYNE3 spectrin repeat containing, nuclear envelope family member 3 0.2198
METTL22 methyltransferase like 22 0.219541
DMRT1 doublesex and mab-3 related transcription factor 1 0.219094
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.21896
FGD5 FYVE, RhoGEF and PH domain containing 5 0.218903
CALD1 caldesmon 1 0.218399
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 0.218325
LCT lactase 0.217891
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.217731
GRID2 glutamate receptor, ionotropic, delta 2 0.21759
TRRAP transformation/transcription domain-associated protein 0.217502
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 0.215841
AJAP1 adherens junctions associated protein 1 0.215841
MTUS2 microtubule associated tumor suppressor candidate 2 0.212946
PDE1A phosphodiesterase 1A, calmodulin-dependent 0.210481
ZPR1 ZPR1 zinc finger 0.209373
GLDC glycine dehydrogenase (decarboxylating) 0.208336
LY9 lymphocyte antigen 9 0.20736
THSD7A thrombospondin, type I, domain containing 7A 0.206439
TNFAIP1 tumor necrosis factor, alpha-induced protein 1 (endothelial) 0.205567
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.205567
EMC2 ER membrane protein complex subunit 2 0.205567
OSBPL3 oxysterol binding protein-like 3 0.205567
SLC22A12 solute carrier family 22 (organic anion/urate transporter), member 12 0.205567
KDM4C lysine (K)-specific demethylase 4C 0.204739
PEX14 peroxisomal biogenesis factor 14 0.204739
TSC1 tuberous sclerosis 1 0.204739
KLHL29 kelch-like family member 29 0.203951
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 0.203199
AGBL4 ATP/GTP binding protein-like 4 0.201793
HIBADH 3-hydroxyisobutyrate dehydrogenase 0.201793
PKHD1L1 polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1 0.20112
CNTN4 contactin 4 0.20112
GPC6 glypican 6 0.200428
LYZL2 lysozyme-like 2 0.200428
ONECUT1 one cut homeobox 1 0.19912
ZNF221 zinc finger protein 221 0.198501
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.198501
GRID1 glutamate receptor, ionotropic, delta 1 0.197903
TTBK1 tau tubulin kinase 1 0.194692
CEP85 centrosomal protein 85kDa 0.19421
FAM107B family with sequence similarity 107, member B 0.193284
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.193284
ZDHHC6 zinc finger, DHHC-type containing 6 0.193284
MCC mutated in colorectal cancers 0.193284
ANXA2 annexin A2 0.193284
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.192406
SDCCAG8 serologically defined colon cancer antigen 8 0.190387
LMX1B LIM homeobox transcription factor 1, beta 0.19001
LIPK lipase, family member K 0.189641
ELL elongation factor RNA polymerase II 0.18928
MSH6 mutS homolog 6 0.18928
PARD3B par-3 family cell polarity regulator beta 0.18928
LHX6 LIM homeobox 6 0.18928
HNF1B HNF1 homeobox B 0.18928
MED15 mediator complex subunit 15 0.18928
CRTAC1 cartilage acidic protein 1 0.187581
DLGAP2 discs, large (Drosophila) homolog-associated protein 2 0.187261
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.186036
ZNF214 zinc finger protein 214 0.186036
PPFIA2 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 0.184893
LPPR1 lipid phosphate phosphatase-related protein type 1 0.183312
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 0.183312
TRAF4 TNF receptor-associated factor 4 0.183312
IFT54 intraflagellar transport 54 0.183312
LARS2 leucyl-tRNA synthetase 2, mitochondrial 0.183312
FBXL13 F-box and leucine-rich repeat protein 13 0.181636
HIP1 huntingtin interacting protein 1 0.18141
FGF14 fibroblast growth factor 14 0.181186
CHST9 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 0.180966
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) 0.180533
CSMD2 CUB and Sushi multiple domains 2 0.180112
ADAM17 ADAM metallopeptidase domain 17 0.1797
NOD2 nucleotide-binding oligomerization domain containing 2 0.178907
FCHO1 FCH domain only 1 0.178907
ADAMTS2 ADAM metallopeptidase with thrombospondin type 1 motif, 2 0.178907
SDHAF3 succinate dehydrogenase complex assembly factor 3 0.178907
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.178524