hepatoma Gene Set

Dataset GeneRIF Biological Term Annotations
Category structural or functional annotations
Type biological term
Description A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.|Tumors or cancer of the LIVER.|A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation. --2002|A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver involvement. Microscopically, there is a wide range of differentiation from tumor to tumor (well differentiated to poorly differentiated tumors). Hepatocellular carcinomas quickly metastasize to regional lymph nodes and lung. The overall median survival of untreated liver cell carcinoma is about 4 months. The most effective treatment of hepatocellular carcinoma is complete resection of the tumor. Lately, an increasing number of tumors have been treated with liver transplantation. (Experimental Factor Ontology, EFO_0000182)
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Genes

320 genes co-occuring with the biological term hepatoma in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ACO1 aconitase 1, soluble
ACSL4 acyl-CoA synthetase long-chain family member 4
ADAM10 ADAM metallopeptidase domain 10
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide
AFP alpha-fetoprotein
AIFM3 apoptosis-inducing factor, mitochondrion-associated, 3
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALAD aminolevulinate dehydratase
ALOX5 arachidonate 5-lipoxygenase
ANG angiogenin, ribonuclease, RNase A family, 5
ANGPTL4 angiopoietin-like 4
ANXA2 annexin A2
ANXA3 annexin A3
APC adenomatous polyposis coli
APOA1 apolipoprotein A-I
APOA5 apolipoprotein A-V
APOB apolipoprotein B
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
APOC3 apolipoprotein C-III
APOE apolipoprotein E
APOH apolipoprotein H (beta-2-glycoprotein I)
AQP8 aquaporin 8
AREG amphiregulin
ARF6 ADP-ribosylation factor 6
ARNTL aryl hydrocarbon receptor nuclear translocator-like
ASIP agouti signaling protein
ATF5 activating transcription factor 5
ATP7B ATPase, Cu++ transporting, beta polypeptide
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2L1 BCL2-like 1
BIRC5 baculoviral IAP repeat containing 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BSG basigin (Ok blood group)
CA3 carbonic anhydrase III
CAPN1 calpain 1, (mu/I) large subunit
CAPN2 calpain 2, (m/II) large subunit
CAPNS1 calpain, small subunit 1
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae)
CD226 CD226 molecule
CD44 CD44 molecule (Indian blood group)
CD46 CD46 molecule, complement regulatory protein
CD47 CD47 molecule
CD81 CD81 molecule
CD82 CD82 molecule
CDH13 cadherin 13
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CKS1B CDC28 protein kinase regulatory subunit 1B
CLDN1 claudin 1
CLOCK clock circadian regulator
COL18A1 collagen, type XVIII, alpha 1
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNNBIP1 catenin, beta interacting protein 1
CTNND1 catenin (cadherin-associated protein), delta 1
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1
DAPK1 death-associated protein kinase 1
DCN decorin
DDX58 DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
DFFB DNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)
DKK4 dickkopf WNT signaling pathway inhibitor 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP1 dual specificity phosphatase 1
E2F1 E2F transcription factor 1
ECI1 enoyl-CoA delta isomerase 1
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EGFR epidermal growth factor receptor
EIF2A eukaryotic translation initiation factor 2A, 65kDa
EP300 E1A binding protein p300
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
ERBB2 erb-b2 receptor tyrosine kinase 2
ERCC2 excision repair cross-complementation group 2
ERCC3 excision repair cross-complementation group 3
ERN1 endoplasmic reticulum to nucleus signaling 1
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAS Fas cell surface death receptor
FBXO7 F-box protein 7
FGF2 fibroblast growth factor 2 (basic)
FHIT fragile histidine triad
FLT1 fms-related tyrosine kinase 1
FOXA2 forkhead box A2
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FOXO4 forkhead box O4
FOXP3 forkhead box P3
FTH1 ferritin, heavy polypeptide 1
FZD9 frizzled class receptor 9
GAPDH glyceraldehyde-3-phosphate dehydrogenase
GFER growth factor, augmenter of liver regeneration
GH1 growth hormone 1
GJA1 gap junction protein, alpha 1, 43kDa
GNMT glycine N-methyltransferase
GPC3 glypican 3
GSK3B glycogen synthase kinase 3 beta
HAMP hepcidin antimicrobial peptide
HDGFL1 hepatoma derived growth factor-like 1
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HINT1 histidine triad nucleotide binding protein 1
HIPK2 homeodomain interacting protein kinase 2
HK2 hexokinase 2
HMBOX1 homeobox containing 1
HMBS hydroxymethylbilane synthase
HMGB1 high mobility group box 1
HMOX1 heme oxygenase 1
HNF1A HNF1 homeobox A
HNF4A hepatocyte nuclear factor 4, alpha
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA9 heat shock 70kDa protein 9 (mortalin)
HSPB1 heat shock 27kDa protein 1
HSPB2 heat shock 27kDa protein 2
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HULC hepatocellular carcinoma up-regulated long non-coding RNA
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFIH1 interferon induced with helicase C domain 1
IFNA2 interferon, alpha 2
IFNL1 interferon, lambda 1
IFT88 intraflagellar transport 88
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2-AS IGF2 antisense RNA
IGF2R insulin-like growth factor 2 receptor
IGFBP1 insulin-like growth factor binding protein 1
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1RAP interleukin 1 receptor accessory protein
IL22 interleukin 22
IL24 interleukin 24
IL6R interleukin 6 receptor
ING1 inhibitor of growth family, member 1
IQSEC1 IQ motif and Sec7 domain 1
ISX intestine-specific homeobox
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
JUNB jun B proto-oncogene
KDR kinase insert domain receptor
KL klotho
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5
LAPTM4B lysosomal protein transmembrane 4 beta
LASP1 LIM and SH3 protein 1
LIPC lipase, hepatic
LPA lipoprotein, Lp(a)
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K2 mitogen-activated protein kinase kinase kinase 2
MAPK14 mitogen-activated protein kinase 14
MAPK8 mitogen-activated protein kinase 8
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MAT1A methionine adenosyltransferase I, alpha
MAT2A methionine adenosyltransferase II, alpha
MCL1 myeloid cell leukemia 1
MET MET proto-oncogene, receptor tyrosine kinase
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase
MIA2 melanoma inhibitory activity 2
MIR1228 microRNA 1228
MIR1291 microRNA 1291
MIR142 microRNA 142
MIR148A microRNA 148a
MIR155 microRNA 155
MIR17HG miR-17-92 cluster host gene
MIR181A1 microRNA 181a-1
MIR205 microRNA 205
MIR21 microRNA 21
MIR210 microRNA 210
MIR223 microRNA 223
MIR27A microRNA 27a
MIR451A microRNA 451a
MIR509-3 microRNA 509-3
MIR520E microRNA 520e
MLC1 megalencephalic leukoencephalopathy with subcortical cysts 1
MLXIPL MLX interacting protein-like
MMP3 matrix metallopeptidase 3
MMP9 matrix metallopeptidase 9
MNT MAX network transcriptional repressor
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MTTP microsomal triglyceride transfer protein
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NDRG2 NDRG family member 2
NFE2L2 nuclear factor, erythroid 2-like 2
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NQO1 NAD(P)H dehydrogenase, quinone 1
NR0B2 nuclear receptor subfamily 0, group B, member 2
NR1H4 nuclear receptor subfamily 1, group H, member 4
NR1I3 nuclear receptor subfamily 1, group I, member 3
NR4A1 nuclear receptor subfamily 4, group A, member 1
OCLN occludin
OGG1 8-oxoguanine DNA glycosylase
OPRM1 opioid receptor, mu 1
ORAI1 ORAI calcium release-activated calcium modulator 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PCBP1 poly(rC) binding protein 1
PDCD1 programmed cell death 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG10 paternally expressed 10
PER1 period circadian clock 1
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIM3 Pim-3 proto-oncogene, serine/threonine kinase
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1
PLIN2 perilipin 2
PLK1 polo-like kinase 1
PLSCR1 phospholipid scramblase 1
POLL polymerase (DNA directed), lambda
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
PPIB peptidylprolyl isomerase B (cyclophilin B)
PRF1 perforin 1 (pore forming protein)
PRKCA protein kinase C, alpha
PRKCI protein kinase C, iota
PROX1 prospero homeobox 1
PTEN phosphatase and tensin homolog
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTK2 protein tyrosine kinase 2
PTPRK protein tyrosine phosphatase, receptor type, K
PTPRT protein tyrosine phosphatase, receptor type, T
PVR poliovirus receptor
QKI QKI, KH domain containing, RNA binding
RAB18 RAB18, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAD23B RAD23 homolog B (S. cerevisiae)
RB1 retinoblastoma 1
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RETN resistin
RGN regucalcin
RICTOR RPTOR independent companion of MTOR, complex 2
RPTOR regulatory associated protein of MTOR, complex 1
SCG3 secretogranin III
SCO2 SCO2 cytochrome c oxidase assembly protein
SDC1 syndecan 1
SDC4 syndecan 4
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFRP1 secreted frizzled-related protein 1
SFRP5 secreted frizzled-related protein 5
SHBG sex hormone-binding globulin
SIRT1 sirtuin 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter), member 2
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1
SLC23A2 solute carrier family 23 (ascorbic acid transporter), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SNAI1 snail family zinc finger 1
SNCG synuclein, gamma (breast cancer-specific protein 1)
SP1 Sp1 transcription factor
SP3 Sp3 transcription factor
SPON2 spondin 2, extracellular matrix protein
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SREBF1 sterol regulatory element binding transcription factor 1
SSB Sjogren syndrome antigen B (autoantigen La)
SSX2IP synovial sarcoma, X breakpoint 2 interacting protein
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIM1 stromal interaction molecule 1
STMN2 stathmin 2
SULF2 sulfatase 2
TBP TATA box binding protein
TERT telomerase reverse transcriptase
TF transferrin
TFR2 transferrin receptor 2
TFRC transferrin receptor
TGFB1 transforming growth factor, beta 1
TGFBI transforming growth factor, beta-induced, 68kDa
THAP11 THAP domain containing 11
THRB thyroid hormone receptor, beta
TJP1 tight junction protein 1
TKTL1 transketolase-like 1
TLR3 toll-like receptor 3
TLR7 toll-like receptor 7
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53 tumor protein p53
TRPC1 transient receptor potential cation channel, subfamily C, member 1
TTR transthyretin
UBD ubiquitin D
USF2 upstream transcription factor 2, c-fos interacting
VEGFA vascular endothelial growth factor A
VIMP VCP-interacting membrane selenoprotein
XPC xeroderma pigmentosum, complementation group C
ZNF24 zinc finger protein 24
ZNF443 zinc finger protein 443