heroin dependence Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores
Category disease or phenotype associations
Type disease
Description An opiate dependence that involves the continued use of heroin despite problems related to use of the substance. (Human Disease Ontology, DOID_9976)
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Genes

63 genes co-occuring with the disease heroin dependence in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.

Symbol Name Standardized Value
DSTN destrin (actin depolymerizing factor) 1.92623
FYB FYN binding protein 1.62694
DRD4 dopamine receptor D4 1.61083
OPRM1 opioid receptor, mu 1 1.57378
OPRD1 opioid receptor, delta 1 1.41621
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.39826
DRD2 dopamine receptor D2 1.39433
ANKK1 ankyrin repeat and kinase domain containing 1 1.37425
PDYN prodynorphin 1.35376
AUTS2 autism susceptibility candidate 2 1.26255
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.11519
MAOA monoamine oxidase A 1.07782
COMT catechol-O-methyltransferase 1.07194
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.04083
TTC12 tetratricopeptide repeat domain 12 1.02397
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 1.02271
HTR3B 5-hydroxytryptamine (serotonin) receptor 3B, ionotropic 0.999503
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 0.9898
CSNK1E casein kinase 1, epsilon 0.98011
DRD1 dopamine receptor D1 0.975062
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 0.908965
NRXN3 neurexin 3 0.823718
FLVCR2 feline leukemia virus subgroup C cellular receptor family, member 2 0.812232
BDNF brain-derived neurotrophic factor 0.799923
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 0.768801
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 0.739488
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 0.730166
GRM3 glutamate receptor, metabotropic 3 0.728547
INSC inscuteable homolog (Drosophila) 0.709572
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 0.709572
HTR1B 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled 0.686691
OPN3 opsin 3 0.685491
RGMB repulsive guidance molecule family member b 0.684692
DRD5 dopamine receptor D5 0.638282
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 0.625711
OPRK1 opioid receptor, kappa 1 0.607323
GABRB3 gamma-aminobutyric acid (GABA) A receptor, beta 3 0.580828
CXADR coxsackie virus and adenovirus receptor 0.544705
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1 0.534635
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 0.534248
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide 0.520731
NOVA2 neuro-oncological ventral antigen 2 0.491978
NR1I3 nuclear receptor subfamily 1, group I, member 3 0.491215
SLC6A2 solute carrier family 6 (neurotransmitter transporter), member 2 0.470332
NOS1 nitric oxide synthase 1 (neuronal) 0.427765
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.420266
DRD3 dopamine receptor D3 0.372587
PENK proenkephalin 0.369258
PER3 period circadian clock 3 0.36187
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 0.359657
HAS1 hyaluronan synthase 1 0.338707
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.324823
NR1I2 nuclear receptor subfamily 1, group I, member 2 0.298731
DCXR dicarbonyl/L-xylulose reductase 0.278297
POMC proopiomelanocortin 0.244345
NEUROD1 neuronal differentiation 1 0.235964
F2R coagulation factor II (thrombin) receptor 0.22937
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 0.20658
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.193285
DLL1 delta-like 1 (Drosophila) 0.191719
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic 0.188938
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6 0.179802
ENO2 enolase 2 (gamma, neuronal) 0.177576