hexetidine-6319 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

196 genes differentially expressed following the hexetidine-6319 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9
ACSL5 acyl-CoA synthetase long-chain family member 5
ADRBK2 adrenergic, beta, receptor kinase 2
ALB albumin
ANKRD1 ankyrin repeat domain 1 (cardiac muscle)
ATF3 activating transcription factor 3
ATXN1 ataxin 1
C5ORF42 chromosome 5 open reading frame 42
C7ORF26 chromosome 7 open reading frame 26
CALD1 caldesmon 1
CDHR2 cadherin-related family member 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CNPPD1 cyclin Pas1/PHO80 domain containing 1
COL6A1 collagen, type VI, alpha 1
COL7A1 collagen, type VII, alpha 1
CREB5 cAMP responsive element binding protein 5
CTTN cortactin
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DTX2 deltex 2, E3 ubiquitin ligase
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EHF ets homologous factor
EPAS1 endothelial PAS domain protein 1
FAM110B family with sequence similarity 110, member B
FAM134B family with sequence similarity 134, member B
FGF23 fibroblast growth factor 23
FYN FYN proto-oncogene, Src family tyrosine kinase
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GPC3 glypican 3
GPR161 G protein-coupled receptor 161
HDAC9 histone deacetylase 9
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEXA hexosaminidase A (alpha polypeptide)
HGF hepatocyte growth factor (hepapoietin A; scatter factor)
HOOK1 hook microtubule-tethering protein 1
HOXB5 homeobox B5
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IBA57 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
IDS iduronate 2-sulfatase
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IGL immunoglobulin lambda locus
IL5RA interleukin 5 receptor, alpha
IL6 interleukin 6
KCNAB1 potassium channel, voltage gated subfamily A regulatory beta subunit 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
LAMP1 lysosomal-associated membrane protein 1
LHX2 LIM homeobox 2
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae)
MT1M metallothionein 1M
MT1X metallothionein 1X
MVK mevalonate kinase
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NRXN3 neurexin 3
NUMA1 nuclear mitotic apparatus protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
ODF2 outer dense fiber of sperm tails 2
PLCG1 phospholipase C, gamma 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PSORS1C1 psoriasis susceptibility 1 candidate 1
PTEN phosphatase and tensin homolog
PTPRE protein tyrosine phosphatase, receptor type, E
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RARG retinoic acid receptor, gamma
REEP1 receptor accessory protein 1
RFPL1 ret finger protein-like 1
RGS12 regulator of G-protein signaling 12
RPP25 ribonuclease P/MRP 25kDa subunit
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa
SPSB3 splA/ryanodine receptor domain and SOCS box containing 3
SRRM2 serine/arginine repetitive matrix 2
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
STAT5B signal transducer and activator of transcription 5B
STC1 stanniocalcin 1
STS steroid sulfatase (microsomal), isozyme S
SUGP1 SURP and G patch domain containing 1
TMEM259 transmembrane protein 259
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNK2 tyrosine kinase, non-receptor, 2
TREM1 triggering receptor expressed on myeloid cells 1
TTLL5 tubulin tyrosine ligase-like family member 5
VWA5A von Willebrand factor A domain containing 5A
WDR1 WD repeat domain 1
ZNF165 zinc finger protein 165
ZNF44 zinc finger protein 44

decreased expression

Symbol Name
ADAP2 ArfGAP with dual PH domains 2
ADAT1 adenosine deaminase, tRNA-specific 1
AFAP1 actin filament associated protein 1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANKZF1 ankyrin repeat and zinc finger domain containing 1
ARHGAP24 Rho GTPase activating protein 24
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5
ARMC4 armadillo repeat containing 4
ARRB2 arrestin, beta 2
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2
BAK1 BCL2-antagonist/killer 1
BEND5 BEN domain containing 5
C4ORF19 chromosome 4 open reading frame 19
CD3D CD3d molecule, delta (CD3-TCR complex)
CHKB choline kinase beta
CISH cytokine inducible SH2-containing protein
CLSPN claspin
CNN2 calponin 2
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CTC1 CTS telomere maintenance complex component 1
DCAF10 DDB1 and CUL4 associated factor 10
DHRS11 dehydrogenase/reductase (SDR family) member 11
DOLK dolichol kinase
ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5
ETV4 ets variant 4
EYA4 EYA transcriptional coactivator and phosphatase 4
GAL3ST4 galactose-3-O-sulfotransferase 4
GBF1 golgi brefeldin A resistant guanine nucleotide exchange factor 1
GDAP1 ganglioside induced differentiation associated protein 1
GNG7 guanine nucleotide binding protein (G protein), gamma 7
GPATCH2L G patch domain containing 2-like
GPX2 glutathione peroxidase 2
GSTT1 glutathione S-transferase theta 1
GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa
GUCY1B2 guanylate cyclase 1, soluble, beta 2 (pseudogene)
HDAC5 histone deacetylase 5
HIST1H2BM histone cluster 1, H2bm
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3
HOXA4 homeobox A4
HOXC4 homeobox C4
IDI2-AS1 IDI2 antisense RNA 1
IFI35 interferon-induced protein 35
IL15RA interleukin 15 receptor, alpha
INPPL1 inositol polyphosphate phosphatase-like 1
KCTD15 potassium channel tetramerization domain containing 15
KDM5C lysine (K)-specific demethylase 5C
KIAA0753 KIAA0753
LIFR leukemia inhibitory factor receptor alpha
LRFN3 leucine rich repeat and fibronectin type III domain containing 3
LRRC37A3 leucine rich repeat containing 37, member A3
MANBA mannosidase, beta A, lysosomal
MAST3 microtubule associated serine/threonine kinase 3
MFSD12 major facilitator superfamily domain containing 12
MYL5 myosin, light chain 5, regulatory
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NOP2 NOP2 nucleolar protein
NXPH4 neurexophilin 4
OPA3 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PALMD palmdelphin
PARP16 poly (ADP-ribose) polymerase family, member 16
PCOLCE procollagen C-endopeptidase enhancer
PKN1 protein kinase N1
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRAME preferentially expressed antigen in melanoma
PRMT7 protein arginine methyltransferase 7
PRR7 proline rich 7 (synaptic)
PSKH1 protein serine kinase H1
PTCD2 pentatricopeptide repeat domain 2
PTGES2 prostaglandin E synthase 2
RAB5B RAB5B, member RAS oncogene family
RBM42 RNA binding motif protein 42
RGL2 ral guanine nucleotide dissociation stimulator-like 2
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RIN1 Ras and Rab interactor 1
SAA4 serum amyloid A4, constitutive
SCAI suppressor of cancer cell invasion
SIRT6 sirtuin 6
SIX1 SIX homeobox 1
SLC12A9 solute carrier family 12, member 9
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1
SYTL2 synaptotagmin-like 2
TEX40 testis expressed 40
THAP7 THAP domain containing 7
THBS3 thrombospondin 3
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TM7SF2 transmembrane 7 superfamily member 2
TMEM121 transmembrane protein 121
TUBG2 tubulin, gamma 2
UBQLN4 ubiquilin 4
WFDC2 WAP four-disulfide core domain 2
ZNF141 zinc finger protein 141
ZNF215 zinc finger protein 215
ZNF268 zinc finger protein 268
ZNF34 zinc finger protein 34
ZNF574 zinc finger protein 574
ZNHIT2 zinc finger, HIT-type containing 2